Piperidines - Pharmacology
Research News and Information

Saturday, November 21, 2009

Decrease in tumor cell oxygen consumption after treatment with vandetanib (ZACTIMA; ZD6474) and its effect on response to radiotherapy.

30 Oct 2009 We investigated the early effects of vandetanib (ZACTIMA; ZD6474), an inhibitor of VEGFR-dependent angiogenesis, on tumor oxygenation and on the possible consequences of combining vandetanib with radiotherapy. Tumor oxygenation, perfusion, cellular ... Read more...

The dopaminergic stabilizer ASP2314/ACR16 selectively interacts with D2(High) receptors.

29 Sep 2009 Dopaminergic stabilizers are recognized as compounds that can either enhance or antagonize dopamine (DA)-dependent behaviors depending on the prevailing dopaminergic tone. The dopaminergic stabilizer ASP2314 is being tested clinically and has been ... Read more...

Multiple protonation states of vesicular acetylcholine transporter detected by binding of [3H]vesamicol.

27 Sep 2009 Vesicular acetylcholine transporter (VAChT) is inhibited by (-)-vesamicol [(-)-trans-2-(4-phenylpiperidino)cyclohexanol], which binds tightly to an allosteric site. The tertiary alkylamine center in (-)-vesamicol is protonated and positively charged ... Read more...

Latest indexed articles for 'Piperidines - Pharmacology'

These are the very latest articles for this heading:

• Decrease in tumor cell oxygen consumption after treatment with vandetanib (ZACTIMA; ZD6474) and its effect on response to radiotherapy. 30 Oct 2009
• The dopaminergic stabilizer ASP2314/ACR16 selectively interacts with D2(High) receptors. 29 Sep 2009
• Multiple protonation states of vesicular acetylcholine transporter detected by binding of [3H]vesamicol. 27 Sep 2009
• The potency of different serotonergic agonists in counteracting opioid evoked cardiorespiratory disturbances. 10 Sep 2009
• NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory. 8 Sep 2009
• Novel pepper extract for enhanced P-glycoprotein inhibition. 30 Aug 2009
• The antiarrhythmic effect and possible ionic mechanisms of pilocarpine on animal models. 30 Aug 2009
• Effects of remifentanil on the spectrum and quantitative parameters of electroencephalogram in propofol anesthesia. 30 Aug 2009
• Auditory event-related potentials, bispectral index, and entropy for the discrimination of different levels of sedation in intensive care unit patients. 30 Aug 2009
• Should dosing of rocuronium in obese patients be based on ideal or corrected body weight? 30 Aug 2009
• Rimonabant induces partial seizures in a patient with a history of generalized epilepsy. 30 Aug 2009
• Contribution of endothelin 1 to the vascular effects of diesel exhaust inhalation in humans. 15 Aug 2009
• Responses to the cannabinoid receptor-1 antagonist, AM251, are more robust with age and with high-fat feeding. 11 Aug 2009
• Spinal endocannabinoids and CB1 receptors mediate C-fiber-induced heterosynaptic pain sensitization. 5 Aug 2009
• Cholinoceptive and cholinergic properties of cardiomyocytes involving an amplification mechanism for vagal efferent effects in sparsely innervated ventricular myocardium. 4 Aug 2009
• CCR3 antagonists: a survey of the patent literature. 30 Jul 2009
• Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase. 30 Jul 2009
• Acute cognitive effects of donepezil in young, healthy volunteers. 30 Jul 2009
• Synthesis and anti-inflammatory activity of novel (4-hydroxyphenyl)(2,4-dimethoxyphenyl) methanone derivatives. 30 Jul 2009
• The inhibitory avoidance test optimized for discovery of cognitive enhancers. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Piperidines'

Definition: A family of hexahydropyridines.

Registry Number: 0

Descriptor UI: D010880

Alternative terms: Piperidines;

Related Mesh Headings: Pyridines;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.383.621;

Online Note: use PIPERIDINES to search AZACYCLONOL 1966-84

History Note: AZACYCLONOL was heading 1963-84