Piperidines - Therapeutic use
Research News and Information

Monday, November 23, 2009

Continuous and intermittent dosing of lonafarnib potentiates the therapeutic efficacy of docetaxel on preclinical human prostate cancer models.

29 Nov 2009 Lonafarnib is a potent, selective farnesyltransferase inhibitor (FTI) undergoing clinical studies for the treatment of solid tumors and hematological malignancies. Preclinically, a number of FTIs, including lonafarnib, interact with taxanes to ... Read more...

Decrease in tumor cell oxygen consumption after treatment with vandetanib (ZACTIMA; ZD6474) and its effect on response to radiotherapy.

30 Oct 2009 We investigated the early effects of vandetanib (ZACTIMA; ZD6474), an inhibitor of VEGFR-dependent angiogenesis, on tumor oxygenation and on the possible consequences of combining vandetanib with radiotherapy. Tumor oxygenation, perfusion, cellular ... Read more...

Combination of vandetanib, radiotherapy, and irinotecan in the LoVo human colorectal cancer xenograft model.

30 Oct 2009 PURPOSE: The tumor growth kinetics of the human LoVo colorectal xenograft model was assessed in response to vandetanib, an orally available receptor tyrosine kinase inhibitor, radiotherapy (RT), or irinotecan (CPT-11), as single therapies and in ... Read more...

Latest indexed articles for 'Piperidines - Therapeutic use'

These are the very latest articles for this heading:

• Continuous and intermittent dosing of lonafarnib potentiates the therapeutic efficacy of docetaxel on preclinical human prostate cancer models. 29 Nov 2009
• Donepezil treatment of patients with MCI: a 48-week randomized, placebo- controlled trial. Nov 2009
• Decrease in tumor cell oxygen consumption after treatment with vandetanib (ZACTIMA; ZD6474) and its effect on response to radiotherapy. 30 Oct 2009
• Combination of vandetanib, radiotherapy, and irinotecan in the LoVo human colorectal cancer xenograft model. 30 Oct 2009
• Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease. 6 Sep 2009
• Successful use of donepezil in treatment of cognitive impairment caused by maintenance electroconvulsive therapy: a case report. 30 Aug 2009
• Targeted therapies in the treatment of advanced/metastatic NSCLC. 30 Aug 2009
• [A case of paclitaxel-induced peripheral neuropathy successfully treated by H2-blocker, lafutidine] 30 Aug 2009
• The effects of counseling spouse caregivers of people with Alzheimer disease taking donepezil and of country of residence on rates of admission to nursing homes and mortality. 30 Aug 2009
• Brief psychosocial therapy for the treatment of agitation in Alzheimer disease (the CALM-AD trial). 30 Aug 2009
• Comment on alvimopan guidelines. 30 Aug 2009
• Rimonabant induces partial seizures in a patient with a history of generalized epilepsy. 30 Aug 2009
• Rimonabant inhibits human colon cancer cell growth and reduces the formation of precancerous lesions in the mouse colon. 30 Aug 2009
• Controlled hypotension for middle ear surgery: a comparison between remifentanil and magnesium sulphate. 15 Aug 2009
• Can cognitive enhancers reduce the risk of falls in older people with mild cognitive impairment? A protocol for a randomised controlled double blind trial. 10 Aug 2009
• Lung cancer trials probe effects of maintenance therapy, targeted agents. 10 Aug 2009
• Economic analysis of alvimopan in North American Phase III efficacy trials. 30 Jul 2009
• Efficacy of blonanserin in combination therapy for treatment-resistant depression. 30 Jul 2009
• The efficacy, safety, and tolerability of donepezil for the treatment of young adults with Down syndrome. 30 Jul 2009
• Comments on "An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606 in patients with treatment-refractory major depressive disorder". 30 Jul 2009

See a longer list of these articles.

Technical information about 'Piperidines'

Definition: A family of hexahydropyridines.

Registry Number: 0

Descriptor UI: D010880

Alternative terms: Piperidines;

Related Mesh Headings: Pyridines;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.383.621;

Online Note: use PIPERIDINES to search AZACYCLONOL 1966-84

History Note: AZACYCLONOL was heading 1963-84