Piperidines
Research News and Information

Saturday, November 21, 2009

Continuous and intermittent dosing of lonafarnib potentiates the therapeutic efficacy of docetaxel on preclinical human prostate cancer models.

29 Nov 2009 Lonafarnib is a potent, selective farnesyltransferase inhibitor (FTI) undergoing clinical studies for the treatment of solid tumors and hematological malignancies. Preclinically, a number of FTIs, including lonafarnib, interact with taxanes to ... Read more...

Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain.

2 Nov 2009 Previous studies of peripheral immune cells have documented that activation of adenosine 2A receptors (A(2A)Rs) decrease proinflammatory cytokine release and increase release of the potent anti-inflammatory cytokine, interleukin-10 (IL-10). Given ... Read more...

Decrease in tumor cell oxygen consumption after treatment with vandetanib (ZACTIMA; ZD6474) and its effect on response to radiotherapy.

30 Oct 2009 We investigated the early effects of vandetanib (ZACTIMA; ZD6474), an inhibitor of VEGFR-dependent angiogenesis, on tumor oxygenation and on the possible consequences of combining vandetanib with radiotherapy. Tumor oxygenation, perfusion, cellular ... Read more...

Latest indexed articles for 'Piperidines'

These are the very latest articles for this heading:

• Continuous and intermittent dosing of lonafarnib potentiates the therapeutic efficacy of docetaxel on preclinical human prostate cancer models. 29 Nov 2009
• Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain. 2 Nov 2009
• Donepezil treatment of patients with MCI: a 48-week randomized, placebo- controlled trial. Nov 2009
• Decrease in tumor cell oxygen consumption after treatment with vandetanib (ZACTIMA; ZD6474) and its effect on response to radiotherapy. 30 Oct 2009
• Comparison between dexmedetomidine and remifentanil for intraoperative controlled hypotension. 30 Oct 2009
• Combination of vandetanib, radiotherapy, and irinotecan in the LoVo human colorectal cancer xenograft model. 30 Oct 2009
• Turbocharging the brain. 29 Sep 2009
• Case report: combined use of donepezil and galantamine in mixed dementia. 29 Sep 2009
• The dopaminergic stabilizer ASP2314/ACR16 selectively interacts with D2(High) receptors. 29 Sep 2009
• Multiple protonation states of vesicular acetylcholine transporter detected by binding of [3H]vesamicol. 27 Sep 2009
• The potency of different serotonergic agonists in counteracting opioid evoked cardiorespiratory disturbances. 10 Sep 2009
• NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory. 8 Sep 2009
• Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease. 6 Sep 2009
• Successful use of donepezil in treatment of cognitive impairment caused by maintenance electroconvulsive therapy: a case report. 30 Aug 2009
• Perioperative recommendations in a child with Fish Odor syndrome. 30 Aug 2009
• Early recovery from anesthesia and extubation in an infant with very long chain acyl-CoA dehydrogenase deficiency using midazolam, mivacurium, and high dose remifentanil. 30 Aug 2009
• Targeted therapies in the treatment of advanced/metastatic NSCLC. 30 Aug 2009
• [A case of paclitaxel-induced peripheral neuropathy successfully treated by H2-blocker, lafutidine] 30 Aug 2009
• Novel pepper extract for enhanced P-glycoprotein inhibition. 30 Aug 2009
• Remifentanil for INSURE in preterm infants: a pilot study for evaluation of efficacy and safety aspects. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Piperidines'

Definition: A family of hexahydropyridines.

Registry Number: 0

Descriptor UI: D010880

Alternative terms: Piperidines;

Related Mesh Headings: Pyridines;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.383.621;

Online Note: use PIPERIDINES to search AZACYCLONOL 1966-84

History Note: AZACYCLONOL was heading 1963-84