Plasminogen Activator Inhibitor 1
Research News and Information

Sunday, November 22, 2009

Requirement of a dynein light chain in TGFbeta/Smad3 signaling.

29 Nov 2009 We have previously reported that the dynein light chain (DLC) km23-1 is required for Smad2-dependent TGFbeta signaling. Here we describe another member of the km23/DYNLRB/LC7/robl family of DLCs, termed km23-2, which is also involved in TGFbeta ... Read more...

Connecting the dots: obesity, fatty acids and cancer.

30 Oct 2009 Obesity is becoming recognized as a common co-morbidity with several disease states including cancer. There is tremendous interest to more fully understand the mechanistic connections between obesity and cancer. This commentary highlights the report ... Read more...

Differential prognostic impact of uPA and PAI-1 in colon and rectal cancer.

19 Sep 2009 BACKGROUND AND OBJECTIVES: Degradation of extracellular matrix is important for tumour growth and invasion, which in part is regulated by the plasminogen activation system. The aim of the study was to evaluate the protein expression of urokinase ... Read more...

Latest indexed articles for 'Plasminogen Activator Inhibitor 1'

These are the very latest articles for this heading:

• Requirement of a dynein light chain in TGFbeta/Smad3 signaling. 29 Nov 2009
• Connecting the dots: obesity, fatty acids and cancer. 30 Oct 2009
• Differential prognostic impact of uPA and PAI-1 in colon and rectal cancer. 19 Sep 2009
• Two distinct expression patterns of urokinase, urokinase receptor and plasminogen activator inhibitor-1 in colon cancer liver metastases. 13 Sep 2009
• Free fatty acids enhance breast cancer cell migration through plasminogen activator inhibitor-1 and SMAD4. 12 Sep 2009
• Fenofibrate differentially regulates plasminogen activator inhibitor-1 gene expression via adenosine monophosphate-activated protein kinase-dependent induction of orphan nuclear receptor small heterodimer partner. 30 Aug 2009
• Plasminogen activator inhibitors regulate cell adhesion through a uPAR-dependent mechanism. 30 Aug 2009
• Effect of ACE inhibition on the fibrinolytic system in patients requiring coronary artery bypass grafting. 23 Aug 2009
• Monocyte urokinase-type plasminogen activator up-regulation reduces thrombus size in a model of venous thrombosis. 20 Aug 2009
• Regulation of intrapleural fibrinolysis by urokinase-alpha-macroglobulin complexes in tetracycline-induced pleural injury in rabbits. 5 Aug 2009
• Omega-3 fatty acid supplementation attenuates oxidative stress, inflammation, and tubulointerstitial fibrosis in the remnant kidney. 3 Aug 2009
• The peritoneal fibrinolytic response to conventional and laparoscopic colonic surgery. 30 Jul 2009
• Plasminogen activator inhibitor type-1 gene 4G/5G polymorphism in Turkish adult patients with asthma. 30 Jul 2009
• The genetics of venous thromboembolism. A meta-analysis involving approximately 120,000 cases and 180,000 controls. 30 Jul 2009
• Prognostic impact of haemostatic derangements in chronic heart failure. 30 Jul 2009
• Recombinant human C1-inhibitor prevents non-specific proteolysis by mutant pro-urokinase during optimal fibrinolysis. 30 Jul 2009
• Regulation of plasminogen activator inhibitor 1 expression in human osteoarthritic chondrocytes by fluid shear stress: role of protein kinase Calpha. 30 Jul 2009
• High negative charge-to-size ratio in polyphosphates and heparin regulates factor VII-activating protease. 29 Jul 2009
• The orphan nuclear receptor SHP attenuates renal fibrosis. 28 Jul 2009
• Deletion of mineralocorticoid receptors from macrophages protects against deoxycorticosterone/salt-induced cardiac fibrosis and increased blood pressure. 25 Jul 2009

See a longer list of these articles.

Technical information about 'Plasminogen Activator Inhibitor 1'

Definition: A member of the serpin family of proteins. It inhibits both the tissue-type and urokinase-type plasminogen activators.

Registry Number: 0

Descriptor UI: D017395

Alternative terms: Plasminogen Activator Inhibitor 1; PAI-1; Type 1 Plasminogen Activator Inhibitor;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Serine Proteinase Inhibitors;

Tree Number: D12.776.124.125.640; D12.776.872.695.500; D23.119.797;

Online Note: use PLASMINOGEN INACTIVATORS to search PAI-1 1990-92

History Note: 93; PAI-1 was see PLASMINOGEN INACTIVATORS 1990-92

Technical Notes: a serpin; DF: note short X ref