Platelet Aggregation - Drug effects
Research News and Information

Saturday, November 21, 2009

A randomized clinical trial investigating the relationship between aprotinin and hypercoagulability in off-pump coronary surgery.

30 Oct 2009 BACKGROUND: Off-pump coronary artery bypass (OPCAB) surgery is associated with a hypercoagulable state in which the platelet thrombin receptor, protease-activated receptor-1 (PAR-1), helps propagate a thrombin burst within saphenous vein grafts. ... Read more...

Predictive values of post-treatment adenosine diphosphate-induced aggregation and vasodilator-stimulated phosphoprotein index for stent thrombosis after acute coronary syndrome in clopidogrel-treated patients.

13 Oct 2009 A low response to clopidogrel has been associated with an increased risk of stent thrombosis. However, the definition of a nonresponse to clopidogrel remains controversial, and different tests have been used to assess the clopidogrel response. The ... Read more...

Effect of D to E mutation of the RGD motif in rhodostomin on its activity, structure, and dynamics: importance of the interactions between the D residue and integrin.

30 Aug 2009 Rhodostomin (Rho) is a snake venom protein containing an RGD motif that specifically inhibits the integrin-binding function. Rho produced in Pichia pastoris inhibits platelet aggregation with a K(I) of 78 nM as potent as native Rho. In contrast, its ... Read more...

Latest indexed articles for 'Platelet Aggregation - Drug effects'

These are the very latest articles for this heading:

• A randomized clinical trial investigating the relationship between aprotinin and hypercoagulability in off-pump coronary surgery. 30 Oct 2009
• Predictive values of post-treatment adenosine diphosphate-induced aggregation and vasodilator-stimulated phosphoprotein index for stent thrombosis after acute coronary syndrome in clopidogrel-treated patients. 13 Oct 2009
• Effect of D to E mutation of the RGD motif in rhodostomin on its activity, structure, and dynamics: importance of the interactions between the D residue and integrin. 30 Aug 2009
• Possible involvement of chemokine-induced platelet activation in thrombophilic diathesis of antiphospholipid syndrome. 30 Aug 2009
• Aspirin resistance. 30 Aug 2009
• Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trials. 29 Aug 2009
• Characterization of a novel focal adhesion kinase inhibitor in human platelets. 26 Aug 2009
• [Cyclooxygenase inhibitors: adverse drug reactions are unavoidable, but only a few are (acutely) dangerous] 26 Aug 2009
• Tailoring antiplatelet therapy based on pharmacogenomics: how well do the data fit? 24 Aug 2009
• Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. 24 Aug 2009
• STIM1, Orai1 and hTRPC1 are important for thrombin- and ADP-induced aggregation in human platelets. 16 Aug 2009
• Platelet reactivity and stent thrombosis: still some issues to solve. 9 Aug 2009
• PAF-antagonistic bicyclo[3.2.1]octanoid neolignans from leaves of Ocotea macrophylla Kunth. (Lauraceae). 8 Aug 2009
• Determinants of occurrence of aortic sclerosis in an aging population. 30 Jul 2009
• Inhibition of gamma-thrombin-induced human platelet aggregation by histone H1subtypes and H1.3 fragments. 30 Jul 2009
• Ticagrelor yields consistent dose-dependent inhibition of ADP-induced platelet aggregation in patients with atherosclerotic disease regardless of genotypic variations in P2RY12, P2RY1, and ITGB3. 30 Jul 2009
• The aptamer ARC1779 is a potent and specific inhibitor of von Willebrand Factor mediated ex vivo platelet function in acute myocardial infarction. 30 Jul 2009
• Inhibition of platelet aggregation with prasugrel and clopidogrel: an integrated analysis in 846 subjects. 30 Jul 2009
• Diabetes mellitus is associated with increased ex vivo-platelet aggregation and decreased response to aspirin - antithrombotic potential of ACE-inhibitors and AT1-antagonists. 30 Jul 2009
• Comparison of platelet aggregation using light transmission and multiple electrode aggregometry in Glanzmann thrombasthenia. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Platelet Aggregation'

Definition: The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.

Descriptor UI: D010974

Alternative terms: Platelet Aggregation; Aggregation, Platelet;

Related Mesh Headings: Platelet Membrane Glycoproteins;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;

Tree Number: G09.188.124.552.624; G09.188.124.560.600.640;

Online Note: search PLATELET ADHESIVENESS 1974

History Note: 76(75); was see under PLATELET ADHESIVENESS 1974-75