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Platelet Aggregation Inhibitors - Chemistry
Research News and Information
Definition of 'Platelet Aggregation Inhibitors'Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. Common names: Platelet Aggregation Inhibitors; Aggregation Inhibitors, Platelet; Inhibitors, Platelet Aggregation; Blood Platelet Antiaggregants; Antiaggregants, Blood Platelet; Platelet Antiaggregants; Antiaggregants, Platelet; Blood Platelet Aggregation Inhibitors; Platelet Inhibitors; Inhibitors, Platelet |
Tuesday, November 24, 2009
6 Sep 2009 
This investigation addressed the paradox that disintegrins and small RGD-ligands readily bind to the resting alphaIIbbeta3 integrin, while macromolecules with similar integrin recognition motifs require an activated, or primed, receptor. Three ... Read more...
16 Aug 2009 Novel inhibitors of lupin diadenosine 5',5'''-P(1),P(4)-tetraphosphate (Ap(4)A) hydrolase have been identified by in silico screening of a large virtual chemical library. Compounds were ranked on the basis of a consensus from six scoring functions. ... Read more...
25 Jun 2009 Endothelial dysfunction and consequent reduction of biosynthesis of endogenous nitric oxide (NO) play an important pathogenetic role in the cardiovascular complications associated with type II diabetes. In this work, the hybrid drugs 3a and 3b, ... Read more...
Latest indexed articles for 'Platelet Aggregation Inhibitors - Chemistry'
These are the very latest articles for this heading:
- Integrin priming dynamics: mechanisms of integrin antagonist-promoted alphaIIbbeta3:PAC-1 molecular recognition. 6 Sep 2009
- Risk of combining PPIs with thienopyridines: fact or fiction?
29 Aug 2009 - Discovery of inhibitors of lupin diadenosine 5',5'''-P(1),P(4)-tetraphosphate hydrolase by virtual screening. 16 Aug 2009
- NO-glibenclamide derivatives: prototypes of a new class of nitric oxide-releasing anti-diabetic drugs. 25 Jun 2009
- Inhibitory effects of oligopeptides from hen egg white on both human platelet aggregation and blood coagulation. 24 Jun 2009
- Piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation. 23 Jun 2009
- Three new 7.3',8.5'-connected bicyclo[3.2.1]octanoids and other neolignans from leaves of Nectandra amazonum NEES. (Lauraceae).
30 May 2009 - NPP-BJ, a nucleotide pyrophosphatase/phosphodiesterase from Bothrops jararaca snake venom, inhibits platelet aggregation. 26 May 2009
- Progress of research on Inonotus obliquus. 27 Apr 2009
- A novel anti-platelet aggregation tripeptide from Agkistrodon acutus venom: isolation and characterization. 3 Apr 2009
- Effects of pomegranate juice and extract polyphenols on platelet function. 30 Mar 2009
- Bioequivalence and tolerability of two clopidogrel salt preparations, besylate and bisulfate: a randomized, open-label, crossover study in healthy Korean male subjects. 30 Mar 2009
- Succinobucol: review of the metabolic, antiplatelet and cardiovascular effects. 30 Mar 2009
- Synthesis, antiplatelet and in silico evaluations of novel N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides. 30 Mar 2009
- Triterpenes from Acanthopanax sessiliflorus fruits and their antiplatelet aggregation activities. 2 Mar 2009
- Purification and characterization of a new platelet aggregation inhibitor with dissociative effect on ADP-induced platelet aggregation, from the venom of Protobothrops elegans (Sakishima-habu). 26 Feb 2009
- Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: inhibitors of factor Xa and platelet aggregation. 24 Feb 2009
- Advances in antiplatelet therapy: agents in clinical development. 31 Jan 2009
- A new insight of anti-platelet effects of sirtinol in platelets aggregation via cyclic AMP phosphodiesterase. 27 Jan 2009
- Determination of eptifibatide concentration in human plasma utilizing the liquid chromatography-tandem mass spectrometry method. 4 Jan 2009
See a longer list of these articles.
Technical information about 'Platelet Aggregation Inhibitors'
Definition: Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
Registry Number: 0
Descriptor UI: D010975
Alternative terms: Platelet Aggregation Inhibitors; Aggregation Inhibitors, Platelet; Inhibitors, Platelet Aggregation; Blood Platelet Antiaggregants; Antiaggregants, Blood Platelet; Platelet Antiaggregants; Antiaggregants, Platelet; Blood Platelet Aggregation Inhibitors; Platelet Inhibitors; Inhibitors, Platelet; Antiplatelet Agents; Agents, Antiplatelet; Antiplatelet Drugs; Drugs, Antiplatelet; Platelet Antagonists; Antagonists, Platelet; Blood Platelet Antagonists; Antagonists, Blood Platelet;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;
Tree Number: D27.505.954.502.780;
History Note: 88
Technical Notes: DF: PLATELET INHIB