Platelet Membrane Glycoproteins - Metabolism
Research News and Information

Monday, November 23, 2009

Existence of exocytotic hemifusion intermediates with a lifetime of up to seconds in type II pneumocytes.

21 Oct 2009 Exocytosis proceeds through prefusion stages such as hemifusion, but hemifusion is still an elusive intermediate of unknown duration. Using darkfield and fluorescence microscopy in ATII (alveolar type II) cells containing large secretory vesicles ... Read more...

The basophil activation test in immediate-type drug allergy.

30 Jul 2009 Diagnosis of drug allergy involves first the recognition of sometimes unusual symptoms as drug allergy and, second, the identification of the eliciting drug. This is an often difficult task, as the clinical picture and underlying pathomechanisms are ... Read more...

Caveolae facilitate but are not essential for platelet-activating factor-mediated calcium mobilization and extracellular signal-regulated kinase activation.

18 Jul 2009 Certain proteins, including receptors and signaling molecules, are known to be enriched in caveolae and lipid rafts. Caveolin-1, the major structural protein of caveolae, specifically interacts with many signaling molecules and, thus, caveolae and ... Read more...

Latest indexed articles for 'Platelet Membrane Glycoproteins - Metabolism'

These are the very latest articles for this heading:

• Existence of exocytotic hemifusion intermediates with a lifetime of up to seconds in type II pneumocytes. 21 Oct 2009
• The basophil activation test in immediate-type drug allergy. 30 Jul 2009
• Caveolae facilitate but are not essential for platelet-activating factor-mediated calcium mobilization and extracellular signal-regulated kinase activation. 18 Jul 2009
• Platelet activating factor/platelet activating factor receptor pathway as a potential therapeutic target in autoimmune diseases. 29 Jun 2009
• Rhinovirus enhances various bacterial adhesions to nasal epithelial cells simultaneously. 29 Jun 2009
• Design and humanization of a murine scFv that blocks human platelet glycoprotein VI in vitro. 23 Jun 2009
• Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations. 21 Jun 2009
• Tetraspanin gene expression levels as potential biomarkers for malignancy of gingival squamous cell carcinoma. 13 Jun 2009
• Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets. 8 Jun 2009
• Human conjunctival epithelial cell responses to platelet-activating factor (PAF): signal transduction and release of proinflammatory cytokines. 4 Jun 2009
• Naturally processed peptides spanning the HPA-1a polymorphism are efficiently generated and displayed from platelet glycoprotein by HLA-DRB3*0101-positive antigen-presenting cells. Jun 2009
• A functional proteomic method for the enrichment of peripheral membrane proteins reveals the collagen binding protein Hsp47 is exposed on the surface of activated human platelets. 30 May 2009
• Single domain antibodies against the collagen signalling receptor glycoprotein VI are inhibitors of collagen induced thrombus formation. 30 May 2009
• cis-Urocanic acid stimulates primary human keratinocytes independently of serotonin or platelet-activating factor receptors. 26 May 2009
• The low-frequency isoform of platelet glycoprotein VIb attenuates ligand-mediated signal transduction but not receptor expression or ligand binding. 20 May 2009
• Formation of syncytia is repressed by tetraspanins in human immunodeficiency virus type 1-producing cells. 18 May 2009
• Blood group O and vWf expression may be involved in development of peptic ulcer disease secondary to Helicobacter pylori infection. 4 May 2009
• The novel Syk inhibitor R406 reveals mechanistic differences in the initiation of GPVI and CLEC-2 signaling in platelets. 22 Apr 2009
• HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa. 21 Apr 2009
• Multivesicular endosome biogenesis in the absence of ESCRTs. 8 Apr 2009

See a longer list of these articles.

Technical information about 'Platelet Membrane Glycoproteins'

Definition: Surface glycoproteins on platelets which have a key role in hemostasis and thrombosis such as platelet adhesion and aggregation. Many of these are receptors.

Registry Number: 0

Descriptor UI: D010980

Alternative terms: Platelet Membrane Glycoproteins; Glycoproteins, Platelet Membrane; Membrane Glycoproteins, Platelet; PM-GPs; Platelet Glycoproteins; Glycoproteins, Platelet;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.395.550.625; D12.776.543.550.625; D12.776.543.750.705.675;

History Note: 87

Technical Notes: /biosyn /drug eff /physiol /ultrastruct permitted