Polyacetylenes - Pharmacology
Research News and Information

Sunday, November 22, 2009

NF-kappaB Activation by compounds found in Platycodon grandiflorum extract.

30 May 2009 Compounds extracted from Platycodon grandiflorum were evaluated for an activation effect on nuclear factor-kappa B (NF-kappaB). In its active state, NF-kappaB turns on the expression of genes related to cell proliferation or death. NF-kappaB ... Read more...

Depigmentation of melanocytes by (2Z,8Z)-matricaria acid methyl ester isolated from Erigeron breviscapus.

30 May 2009 To discover an active skin depigmenting agent, we isolated a novel inhibitor of melanin biosynthesis from the methanol extract of Erigeron breviscapus using a bioactivity-guided fractionation and identified it as (2Z,8Z)-matricaria acid methyl ester ... Read more...

Isolation and identification of a potent antimalarial and antibacterial polyacetylene from Bidens pilosa.

2 Mar 2009 Diseases caused by malaria parasites and pathogenic bacteria were thought to be on the brink of eradication in the 1950-1960s, but they have once again become a serious threat to mankind as a result of the appearance of multidrug resistant strains. ... Read more...

Latest indexed articles for 'Polyacetylenes - Pharmacology'

These are the very latest articles for this heading:

• NF-kappaB Activation by compounds found in Platycodon grandiflorum extract. 30 May 2009
• Depigmentation of melanocytes by (2Z,8Z)-matricaria acid methyl ester isolated from Erigeron breviscapus. 30 May 2009
• Isolation and identification of a potent antimalarial and antibacterial polyacetylene from Bidens pilosa. 2 Mar 2009
• Plant growth regulating activity of three polyacetylenes from Helianthus annuus L. 30 Dec 2008
• Phytotoxic polyacetylenes from roots of Russian knapweed (Acroptilon repens (L.) DC.). 9 Sep 2008
• Anti-TB polyynes from the roots of Angelica sinensis. 29 Jun 2008
• Antimycobacterial polyacetylenes from Levisticum officinale. 29 Apr 2008
• Purple carrot (Daucus carota L.) polyacetylenes decrease lipopolysaccharide-induced expression of inflammatory proteins in macrophage and endothelial cells. 22 Apr 2008
• Polyacetylenes from the roots of cultivated-wild ginseng and their cytotoxicity in vitro. 30 Jan 2008
• Effects of a polyacetylene from Panax ginseng on Na+ currents in rat dorsal root ganglion neurons. 2 Dec 2007
• Cytotoxic C47-polyacetylene carboxylic acids from a marine sponge Pertrosia sp. 5 Nov 2007
• A polyacetylene compound from herbal medicine regulates genes associated with thrombosis in endothelial cells. 10 Oct 2007
• Antiprotozoal polyacetylenes from the Tanzanian medicinal plant Cussonia zimmermannii. 7 Oct 2007
• Hederyne A, a new antimicrobial polyacetylene from galls of Hedera rhombea Bean. 30 Aug 2007
• Dendrazawaynes A and B, antifungal polyacetylenes from Dendranthema zawadskii (Asteraceae). 7 Aug 2007
• A novel polyacetylene significantly inhibits angiogenesis and promotes apoptosis in human endothelial cells through activation of the CDK inhibitors and caspase-7. 9 Jun 2007
• Growth inhibitory indole acetic acid polyacetylenic ester from Japanese ivy (Hedera rhombea Bean). 23 May 2007
• A bioactive polyacetylene compound isolated from Centella asiatica. 20 May 2007
• Inhibition of cyclooxygenase-2 and telomerase activities in human leukemia cells by dideoxypetrosynol A, a polyacetylene from the marine sponge Petrosia sp. 30 Dec 2006
• Cytopiloyne, a novel polyacetylenic glucoside from Bidens pilosa, functions as a T helper cell modulator. 17 Oct 2006

See a longer list of these articles.

Technical information about 'Polyacetylenes'

Definition: Hydrocarbons with more than one triple bond; or an oxidized form of POLYENES. They can react with SULFUR to form THIOPHENES.

Registry Number: 25067-58-7

Descriptor UI: D053279

Alternative terms: Polyacetylenes; Polyynes; Polyacetylene;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.455.326.397.662;

History Note: 2007