Polymorphism, Single Nucleotide
Research News and Information

Sunday, November 22, 2009

Hereditary hemochromatosis gene (HFE) variants are associated with birth weight and childhood leukemia risk.

13 Dec 2009 BACKGROUND: Our original studies reported an association between the iron-metabolism gene HFE and risk of childhood acute lymphoblastic leukemia (ALL), and a birth weight association in ALL. Through its effect on cell proliferation, iron is involved ... Read more...

Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer.

29 Nov 2009 Although preliminary evidence suggests that germline variation in genes involved in steroid hormone metabolism may alter breast cancer prognosis, this has not been systematically evaluated. We examined associations between germline polymorphisms in ... Read more...

Deficient serum mannose-binding lectin levels and MBL2 polymorphisms increase the risk of single and recurrent Cryptosporidium infections in young children.

13 Nov 2009 Mannose-binding lectin (MBL) is an evolutionarily conserved protein that functions in human innate immunity by binding to microbial surfaces and promoting opsonophagocytosis. MBL has been shown to bind to Cryptosporidium sporozoites, and earlier ... Read more...

Latest indexed articles for 'Polymorphism, Single Nucleotide'

These are the very latest articles for this heading:

• Hereditary hemochromatosis gene (HFE) variants are associated with birth weight and childhood leukemia risk. 13 Dec 2009
• Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer. 29 Nov 2009
• Deficient serum mannose-binding lectin levels and MBL2 polymorphisms increase the risk of single and recurrent Cryptosporidium infections in young children. 13 Nov 2009
• Radiation-induced sequelae measured by means of lymphocyte apoptosis: importance of certain single nucleotide polymorphisms: in regard to Schnarr et al. (Int J Radiat Oncol Biol Phys 2009). 13 Nov 2009
• Genetic evidence for the aggravation of Plasmodium falciparum malaria by interleukin 4. 13 Nov 2009
• Restriction fragment length polymorphism typing demonstrates substantial diversity among Pneumocystis jirovecii isolates. 13 Nov 2009
• Chromosomal abnormalities and novel disease-related regions in progression from Barrett's esophagus to esophageal adenocarcinoma. 13 Nov 2009
• Genome-wide profiling of chromosomal alterations in renal cell carcinoma using high-density single nucleotide polymorphism arrays. 13 Nov 2009
• Myelodysplastic syndromes. 3 Nov 2009
• Interleukin-1 beta single-nucleotide polymorphism's C allele is associated with elevated risk of gastric cancer in Helicobacter pylori-infected Peruvians. 30 Oct 2009
• Association of IL2RA and IL2RB with rheumatoid arthritis: a replication study in a Dutch population. 30 Oct 2009
• Beyond proof of principle: new genes for Alzheimer's disease through collaboration. 30 Oct 2009
• Postpartum mood disorders: genetic progress and treatment paradigms. 30 Oct 2009
• Regarding "Identification of a genetic variant associated with abdominal aortic aneurysms on chromosome 3p12.3 by genome wide association". 30 Oct 2009
• TP53 R72P and MDM2 SNP309 polymorphisms in modification of childhood acute lymphoblastic leukemia susceptibility. 30 Oct 2009
• Association of polymorphisms in regulatory regions of interleukin-12p40 gene and cytokine serum level with colorectal cancer. 30 Oct 2009
• Consistent genomic alterations in carcinoma in situ of the urinary bladder confirm the presence of two major pathways in bladder cancer development. 30 Oct 2009
• CDK4 IVS4-nt40G-->A and T2D-associated obesity in Italians. 30 Oct 2009
• Common candidate gene variants are associated with QT interval duration in the general population. 23 Oct 2009
• Association of APOE polymorphism with chronic kidney disease in a nationally representative sample: a Third National Health and Nutrition Examination Survey (NHANES III) Genetic Study. 21 Oct 2009

See a longer list of these articles.

Technical information about 'Polymorphism, Single Nucleotide'

Definition: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.

Descriptor UI: D020641

Alternative terms: Polymorphism, Single Nucleotide; Nucleotide Polymorphism, Single; Nucleotide Polymorphisms, Single; Polymorphisms, Single Nucleotide; Single Nucleotide Polymorphisms; SNPs; Single Nucleotide Polymorphism;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G05.365.795.598;

History Note: 2000

Technical Notes: do not confuse with POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL