Prefrontal Cortex - Drug effects
Research News and Information

Saturday, November 21, 2009

Differential effects of topiramate on prefrontal glutamatergic transmission when combined with raclopride or clozapine.

29 Sep 2009 Treatment with topiramate may improve negative symptoms in schizophrenia when added to typical antipsychotic drugs (APDs) but not to clozapine. Both dopaminergic and glutamatergic transmissions in the medial prefrontal cortex (mPFC) are facilitated ... Read more...

Formation of spatial memory in rats with ischemic lesions to the prefrontal cortex; effects of a synthetic analog of ACTH(4-7).

21 Sep 2009 Photochemically induced thrombosis of blood vessels in the prefrontal cortex in rats was shown to lead to ischemic infarcts in the lesion zone. Bilateral ischemic lesioning of the prefrontal cortex degraded measures of spatial memory when animals ... Read more...

An FMRI study of the effects of psychostimulants on default-mode processing during Stroop task performance in youths with ADHD.

13 Sep 2009 OBJECTIVE: The authors examined the effect of psychostimulants on brain activity in children and adolescents with ADHD performing the Stroop Color and Word Test. METHOD: The authors acquired 52 functional MRI scans in 16 youths with ADHD who were ... Read more...

Latest indexed articles for 'Prefrontal Cortex - Drug effects'

These are the very latest articles for this heading:

• Differential effects of topiramate on prefrontal glutamatergic transmission when combined with raclopride or clozapine. 29 Sep 2009
• Formation of spatial memory in rats with ischemic lesions to the prefrontal cortex; effects of a synthetic analog of ACTH(4-7). 21 Sep 2009
• An FMRI study of the effects of psychostimulants on default-mode processing during Stroop task performance in youths with ADHD. 13 Sep 2009
• Dopaminergic response to graded dopamine concentration elicited by four amphetamine doses. 30 Aug 2009
• Dorsal hippocampal regulation of memory reconsolidation processes that facilitate drug context-induced cocaine-seeking behavior in rats. 25 Aug 2009
• In vivo evidence that constitutive activity of serotonin2C receptors in the medial prefrontal cortex participates in the control of dopamine release in the rat nucleus accumbens: differential effects of inverse agonist versus antagonist. 20 Aug 2009
• The neurochemistry of rule use. 13 Aug 2009
• Opposite role of infralimbic and prelimbic cortex in the tachycardiac response evoked by acute restraint stress in rats. 13 Aug 2009
• Nucleus accumbens neurons exhibit synaptic scaling that is occluded by repeated dopamine pre-exposure. 5 Aug 2009
• M1 receptors mediate cholinergic modulation of excitability in neocortical pyramidal neurons. 3 Aug 2009
• Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: an in vivo localized (1)H MRS study. 30 Jul 2009
• Plasticity of L-type Ca2+ channels after cocaine withdrawal. 30 Jul 2009
• GABA and cortical inhibition in motor and non-motor regions using combined TMS-EEG: a time analysis. 23 Jul 2009
• Upregulation of GLT1 attenuates cue-induced reinstatement of cocaine-seeking behavior in rats. 20 Jul 2009
• Decreased expression of NMDA receptor-associated proteins in frontal cortex of elderly patients with schizophrenia. 13 Jul 2009
• Prefrontal cortex and spinal cord mediated anti-neuropathy and analgesia induced by sarcosine, a glycine-T1 transporter inhibitor. Jul 2009
• Downregulation of oligodendrocyte transcripts is associated with impaired prefrontal cortex function in rats. 29 Jun 2009
• Discovery of a new class of non-imidazole oxazoline-based histamine H(3) receptor (H(3)R) inverse agonists. 29 Jun 2009
• Changes in hyporesponsiveness to acute amphetamine and age differences in tyrosine hydroxylase immunoreactivity in the brain over adolescence in male and female rats. 29 Jun 2009
• Extended daily access to cocaine results in distinct alterations in Homer 1b/c and NMDA receptor subunit expression within the medial prefrontal cortex. 29 Jun 2009

See a longer list of these articles.

Technical information about 'Prefrontal Cortex'

Definition: The rostral part of the frontal lobe, bounded by the inferior precentral fissure in humans, which receives projection fibers from the mediodorsal nucleus of the thalamus. The prefrontal cortex receives afferent fibers from numerous structures of the diencephalon, mesencephalon, and limbic system as well as cortical afferents of visual, auditory, and somatic origin.

Descriptor UI: D017397

Alternative terms: Prefrontal Cortex; Cortex, Prefrontal;

Allowable Qualifiers: abnormalities; anatomy & histology; blood supply; cytology; drug effects; embryology; enzymology; growth & development; immunology; injuries; metabolism; microbiology; parasitology; pathology; physiology; physiopathology; radiation effects; radiography; radionuclide imaging; secretion; surgery; transplantation; ultrastructure; ultrasonography; chemistry; virology;

Tree Number: A08.186.211.730.885.287.500.270.700;

History Note: 93

Technical Notes: "rostral part of the frontal lobe"