Prefrontal Cortex - Metabolism
Research News and Information

Saturday, November 21, 2009

Reward-seeking and discrimination deficits displayed by hypodopaminergic mice are prevented in mice lacking dopamine D4 receptors.

30 Oct 2009 The dopamine D4 receptor (D4R) is predominantly expressed in the prefrontal cortex, a brain area that integrates motor, rewarding, and cognitive information. Because participation of D4Rs in executive learning is largely unknown, we challenged D4R ... Read more...

Increased expression of the NR2A NMDA receptor subunit in the prefrontal cortex of rats reared in isolation.

29 Sep 2009 A hypofunction of the N-methyl-D-aspartate (NMDA) receptor has been implicated in the pathophysiology of schizophrenia. Compelling evidence of altered NMDA receptor subunit expression in the schizophrenic brain has not, however, so far emerged. Rats ... Read more...

Effects of overnight sleep restriction on brain chemistry and mood in women with unipolar depression and healthy controls.

30 Aug 2009 BACKGROUND: Partial or total overnight sleep deprivation produces immediate mood improvement in about 50% of patients with depression, but not in healthy controls. Our objectives were to compare the neurochemical changes that accompanied partial ... Read more...

Latest indexed articles for 'Prefrontal Cortex - Metabolism'

These are the very latest articles for this heading:

• Reward-seeking and discrimination deficits displayed by hypodopaminergic mice are prevented in mice lacking dopamine D4 receptors. 30 Oct 2009
• Increased expression of the NR2A NMDA receptor subunit in the prefrontal cortex of rats reared in isolation. 29 Sep 2009
• Serotonergic modulation of basal ganglia circuits: complexity and therapeutic opportunities. 13 Sep 2009
• Histone methylation and decreased expression of TrkB.T1 in orbital frontal cortex of suicide completers. 30 Aug 2009
• Effects of overnight sleep restriction on brain chemistry and mood in women with unipolar depression and healthy controls. 30 Aug 2009
• Dopaminergic response to graded dopamine concentration elicited by four amphetamine doses. 30 Aug 2009
• In vivo evidence that constitutive activity of serotonin2C receptors in the medial prefrontal cortex participates in the control of dopamine release in the rat nucleus accumbens: differential effects of inverse agonist versus antagonist. 20 Aug 2009
• Gender difference in relationship between anxiety-related personality traits and cerebral brain glucose metabolism. 11 Aug 2009
• Nucleus accumbens neurons exhibit synaptic scaling that is occluded by repeated dopamine pre-exposure. 5 Aug 2009
• Right prefrontal brain activation due to Stroop interference is altered in attention-deficit hyperactivity disorder - A functional near-infrared spectroscopy study. 4 Aug 2009
• Selective activation of dorsal raphe nucleus-projecting neurons in the ventral medial prefrontal cortex by controllable stress. Aug 2009
• [Influence of stress-resistance on changes in the rat prefrontal cortex phospholipid composition during chronic immobilization] 30 Jul 2009
• Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: an in vivo localized (1)H MRS study. 30 Jul 2009
• Should I stay or should I go: genetic bases for uncertainty-driven exploration. 30 Jul 2009
• Altered prefrontal glutamate-glutamine-gamma-aminobutyric acid levels and relation to low cognitive performance and depressive symptoms in type 1 diabetes mellitus. 30 Jul 2009
• Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory. 27 Jul 2009
• Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation. 24 Jul 2009
• Reciprocal patterns of c-Fos expression in the medial prefrontal cortex and amygdala after extinction and renewal of conditioned fear. 22 Jul 2009
• Prefrontal and striatal dopaminergic genes predict individual differences in exploration and exploitation. 18 Jul 2009
• Decreased expression of NMDA receptor-associated proteins in frontal cortex of elderly patients with schizophrenia. 13 Jul 2009

See a longer list of these articles.

Technical information about 'Prefrontal Cortex'

Definition: The rostral part of the frontal lobe, bounded by the inferior precentral fissure in humans, which receives projection fibers from the mediodorsal nucleus of the thalamus. The prefrontal cortex receives afferent fibers from numerous structures of the diencephalon, mesencephalon, and limbic system as well as cortical afferents of visual, auditory, and somatic origin.

Descriptor UI: D017397

Alternative terms: Prefrontal Cortex; Cortex, Prefrontal;

Allowable Qualifiers: abnormalities; anatomy & histology; blood supply; cytology; drug effects; embryology; enzymology; growth & development; immunology; injuries; metabolism; microbiology; parasitology; pathology; physiology; physiopathology; radiation effects; radiography; radionuclide imaging; secretion; surgery; transplantation; ultrastructure; ultrasonography; chemistry; virology;

Tree Number: A08.186.211.730.885.287.500.270.700;

History Note: 93

Technical Notes: "rostral part of the frontal lobe"