Prefrontal Cortex
Research News and Information

Friday, November 20, 2009

Reward-seeking and discrimination deficits displayed by hypodopaminergic mice are prevented in mice lacking dopamine D4 receptors.

30 Oct 2009 The dopamine D4 receptor (D4R) is predominantly expressed in the prefrontal cortex, a brain area that integrates motor, rewarding, and cognitive information. Because participation of D4Rs in executive learning is largely unknown, we challenged D4R ... Read more...

Altered corticostriatal functional connectivity in obsessive-compulsive disorder.

30 Oct 2009 CONTEXT: Neurobiological models of obsessive-compulsive disorder (OCD) emphasize disturbances in the function and connectivity of brain corticostriatal networks, or "loops." Although neuroimaging studies of patients have supported this network model ... Read more...

Altered effect of dopamine transporter 3'UTR VNTR genotype on prefrontal and striatal function in schizophrenia.

30 Oct 2009 CONTEXT: The dopamine transporter plays a key role in the regulation of central dopaminergic transmission, which modulates cognitive processing. Disrupted dopamine function and impaired executive processing are robust features of schizophrenia. ... Read more...

Latest indexed articles for 'Prefrontal Cortex'

These are the very latest articles for this heading:

• Reward-seeking and discrimination deficits displayed by hypodopaminergic mice are prevented in mice lacking dopamine D4 receptors. 30 Oct 2009
• Altered corticostriatal functional connectivity in obsessive-compulsive disorder. 30 Oct 2009
• Altered effect of dopamine transporter 3'UTR VNTR genotype on prefrontal and striatal function in schizophrenia. 30 Oct 2009
• Resolving response, decision, and strategic control: evidence for a functional topography in dorsomedial prefrontal cortex. 19 Oct 2009
• Cocaine exposure in utero alters synaptic plasticity in the medial prefrontal cortex of postnatal rats. 5 Oct 2009
• Association of ideomotor apraxia with frontal gray matter volume loss in corticobasal syndrome. 29 Sep 2009
• Anodal transcranial direct current stimulation of the prefrontal cortex enhances complex verbal associative thought. 29 Sep 2009
• The medial temporal lobe and the left inferior prefrontal cortex jointly support interference resolution in verbal working memory. 29 Sep 2009
• Distinct orbitofrontal regions encode stimulus and choice valuation. 29 Sep 2009
• Differential effects of topiramate on prefrontal glutamatergic transmission when combined with raclopride or clozapine. 29 Sep 2009
• Increased expression of the NR2A NMDA receptor subunit in the prefrontal cortex of rats reared in isolation. 29 Sep 2009
• Evidence for a common representation of decision values for dissimilar goods in human ventromedial prefrontal cortex. 28 Sep 2009
• Tracking the emergence of conceptual knowledge during human decision making. 22 Sep 2009
• Neuronal activity in rat medial prefrontal cortex during sucrose solution intake. 21 Sep 2009
• Formation of spatial memory in rats with ischemic lesions to the prefrontal cortex; effects of a synthetic analog of ACTH(4-7). 21 Sep 2009
• Gray matter changes related to chronic posttraumatic headache. 20 Sep 2009
• Orbitofrontal and anterior cingulate cortex neurons selectively process cocaine-associated environmental cues in the rhesus monkey. 14 Sep 2009
• The structural integrity of an amygdala-prefrontal pathway predicts trait anxiety. 14 Sep 2009
• The convergence of information about rewarding and aversive stimuli in single neurons. 14 Sep 2009
• Medial prefrontal cortex, secondary hyperalgesia, and the default mode network. 14 Sep 2009

See a longer list of these articles.

Technical information about 'Prefrontal Cortex'

Definition: The rostral part of the frontal lobe, bounded by the inferior precentral fissure in humans, which receives projection fibers from the mediodorsal nucleus of the thalamus. The prefrontal cortex receives afferent fibers from numerous structures of the diencephalon, mesencephalon, and limbic system as well as cortical afferents of visual, auditory, and somatic origin.

Descriptor UI: D017397

Alternative terms: Prefrontal Cortex; Cortex, Prefrontal;

Allowable Qualifiers: abnormalities; anatomy & histology; blood supply; cytology; drug effects; embryology; enzymology; growth & development; immunology; injuries; metabolism; microbiology; parasitology; pathology; physiology; physiopathology; radiation effects; radiography; radionuclide imaging; secretion; surgery; transplantation; ultrastructure; ultrasonography; chemistry; virology;

Tree Number: A08.186.211.730.885.287.500.270.700;

History Note: 93

Technical Notes: "rostral part of the frontal lobe"