Presenilin-2
Research News and Information

Sunday, November 22, 2009

Green tea (-)-epigallocatechin-3-gallate inhibits beta-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-kappaB pathways in mice.

3 Aug 2009 Alzheimer's disease (AD) is characterized by the extracellular deposition of beta-amyloid peptide (Abeta) in cerebral plaques. Abeta is derived from the beta-amyloid precursor protein (APP) by the enzymes alpha-, beta- and gamma-secretase. Compounds ... Read more...

Presenilin enhancer-2 (PSENEN), a component of the gamma-secretase complex, is involved in adipocyte differentiation.

30 Jun 2009 This study was conducted to identify genes expressed during adipocyte differentiation of bovine intramuscular fibroblast-like cells using differential display reverse-transcriptase polymerase chain reaction. The presenilin enhancer-2 (PSENEN) gene ... Read more...

Transcriptional regulation of the murine Presenilin-2 gene reveals similarities and differences to its human orthologue.

28 Jun 2009 Inherited Presenilin-2 mutations cause familial Alzheimer's disease, and its regulation may play a role in sporadic cases. The human Presenilin-2 (PSEN2) regulatory region includes two separate promoters modulated by Egr-1, a transcription factor ... Read more...

Latest indexed articles for 'Presenilin-2'

These are the very latest articles for this heading:

• Green tea (-)-epigallocatechin-3-gallate inhibits beta-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-kappaB pathways in mice. 3 Aug 2009
• Presenilin enhancer-2 (PSENEN), a component of the gamma-secretase complex, is involved in adipocyte differentiation. 30 Jun 2009
• Transcriptional regulation of the murine Presenilin-2 gene reveals similarities and differences to its human orthologue. 28 Jun 2009
• Independent and cooperative action of Psen2 with Psen1 in zebrafish embryos. 25 Jun 2009
• Alterations in excitotoxicity and prostaglandin metabolism in a transgenic mouse model of Alzheimer's disease. 24 Jun 2009
• Oxidative damage increased in presenilin1/presenilin2 conditional double knockout mice. 30 May 2009
• An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor. 15 Apr 2009
• Estradiol-induced regression in T47D:A18/PKCalpha tumors requires the estrogen receptor and interaction with the extracellular matrix. 30 Mar 2009
• Hyperhomocysteinemia increases beta-amyloid by enhancing expression of gamma-secretase and phosphorylation of amyloid precursor protein in rat brain. 3 Mar 2009
• A novel Italian presenilin 2 gene mutation with prevalent behavioral phenotype. 27 Feb 2009
• Does the presenilin 2 gene predispose to schizophrenia? 13 Feb 2009
• Reduced anxiety in the mice expressing mutant (N141I) presenilin 2. 30 Jan 2009
• Nuclear signalling by tumour-associated antigen EpCAM. 9 Jan 2009
• Paradigms lost: rethinking psychiatry in the postgenome era. 30 Dec 2008
• Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer. 30 Dec 2008
• Gastric differentiation markers expression is potentially useful for the detection of ulcerative colitis-associated dysplasias. 30 Dec 2008
• Estrogen activities and the cellular effects of natural progesterone from wild yam extract in mcf-7 human breast cancer cells. 30 Dec 2008
• Altering presenilin gene activity in zebrafish embryos causes changes in expression of genes with potential involvement in Alzheimer's disease pathogenesis. 30 Dec 2008
• [Alzheimer disease: autosomal dominant forms] 8 Dec 2008
• Presenilin-dependent expression of STIM proteins and dysregulation of capacitative Ca2+ entry in familial Alzheimer's disease. 4 Dec 2008

See a longer list of these articles.

Technical information about 'Presenilin-2'

Definition: Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an essential component of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PROTEIN precursors. PSEN2 mutations cause ALZHEIMER DISEASE type 4.

Registry Number: 0

Descriptor UI: D053766

Alternative terms: Presenilin-2; Presenilin 2;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.543.696.750;

History Note: 2007