Promoter Regions, Genetic - Drug effects
Research News and Information

Monday, November 23, 2009

A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease.

29 Sep 2009 Agonists of the peroxisome proliferator activated receptor gamma (PPARgamma) have been shown to reduce inflammatory responses in several animal models of neurological diseases and conditions and to reduce amyloid burden in transgenic mice expressing ... Read more...

Glucocorticoids can activate the alpha-ENaC gene promoter independently of SGK1.

23 Sep 2009 The role of SGK1 (serum- and glucocorticoid-induced protein kinase 1) in the glucocorticoid induction of alpha-ENaC (epithelial Na+ channel alpha subunit) gene transcription was explored by monitoring the transcriptional activity of a ... Read more...

Rutecarpine ameliorates bodyweight gain through the inhibition of orexigenic neuropeptides NPY and AgRP in mice.

31 Aug 2009 Orexigenic neuropeptides NPY and AgRP play major roles in feeding and are closely related to obesity and diabetic metabolic syndrome. This study explored the inhibitory effect of rutecarpine on feeding and obesity in high-fat-diet-induced (C57BL/6) ... Read more...

Latest indexed articles for 'Promoter Regions, Genetic - Drug effects'

These are the very latest articles for this heading:

• A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease. 29 Sep 2009
• Glucocorticoids can activate the alpha-ENaC gene promoter independently of SGK1. 23 Sep 2009
• Rutecarpine ameliorates bodyweight gain through the inhibition of orexigenic neuropeptides NPY and AgRP in mice. 31 Aug 2009
• miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses. 29 Aug 2009
• Knockdown of the aryl hydrocarbon receptor attenuates excitotoxicity and enhances NMDA-induced BDNF expression in cortical neurons. 25 Aug 2009
• PMA induces expression from the herpes simplex virus thymidine kinase promoter via the activation of JNK and ERK in the presence of adenoviral E1A proteins. 21 Aug 2009
• Transcriptional regulation of mitochondrial glycerophosphate acyltransferase is mediated by distal promoter via ChREBP and SREBP-1. 11 Aug 2009
• Rev-erb beta regulates the Srebp-1c promoter and mRNA expression in skeletal muscle cells. 10 Aug 2009
• Statins, fibrates and retinoic acid upregulate mitochondrial acylcarnitine carrier gene expression. 4 Aug 2009
• Nicotine stimulates PPARbeta/delta expression in human lung carcinoma cells through activation of PI3K/mTOR and suppression of AP-2alpha. 2 Aug 2009
• Gene activation by dissociation of an inhibitor from a transcriptional activation domain. Aug 2009
• Thrombin induces the expression of oncostatin M via AP-1 activation in human macrophages: a link between coagulation and inflammation. Aug 2009
• Induction of MMP-1 (collagenase-1) by relaxin in fibrocartilaginous cells requires both the AP-1 and PEA-3 promoter sites. 30 Jul 2009
• Characterization of cis-regulatory elements conferring mercury-induced interleukin-4 gene expression in rat mast cells: a role for signal transducer and activator of transcription 6 and TATA box binding sites. 30 Jul 2009
• Altered gene expression in the brain and ovaries of zebrafish (Danio rerio) exposed to the aromatase inhibitor fadrozole: microarray analysis and hypothesis generation. 30 Jul 2009
• Transcriptional activation of an anti-oxidant mouse Pon2 gene by dexamethasone. 29 Jul 2009
• MyD88 and TRIF mediate the cyclic adenosine monophosphate (cAMP) induced corticotropin releasing hormone (CRH) expression in JEG3 choriocarcinoma cell line. 15 Jul 2009
• Low pH stimulates vasopressin V2 receptor promoter activity and enhances downregulation induced by V1a receptor stimulation. 6 Jul 2009
• Transcriptional activation of the gamma-globin gene in baboons treated with decitabine and in cultured erythroid progenitor cells involves different mechanisms. 30 Jun 2009
• Transcription factor GATA-3 in Atlantic salmon (Salmo salar): molecular characterization, promoter activity and expression analysis. 30 Jun 2009

See a longer list of these articles.

Technical information about 'Promoter Regions, Genetic'

Definition: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.

Descriptor UI: D011401

Alternative terms: Promoter Regions, Genetic; Genetic Promoter Region; Genetic Promoter Regions; Promoter Region, Genetic; Region, Genetic Promoter; Regions, Genetic Promoter; Promoter Regions; Promoter Region; Region, Promoter; Regions, Promoter; Promotor Regions; Promotor Region; Region, Promotor; Regions, Promotor; Late Promoters, Genetic; Genetic Late Promoter; Late Promoter, Genetic; Middle Promoters, Genetic; Genetic Middle Promoters; Middle Promoter, Genetic; Promoters, Genetic Middle; rRNA Promoter; Promoter, rRNA; Promoters, rRNA; rRNA Promoters; Promoter, Genetic; Genetic Promoter; Genetic Promoters; Promoters, Genetic; Promotor, Genetic; Genetic Promotor; Genetic Promotors; Promotors, Genetic; Pseudopromoter, Genetic; Genetic Pseudopromoter; Genetic Pseudopromoters; Pseudopromoters, Genetic; Early Promoters, Genetic; Early Promoter, Genetic; Promoter, Genetic Early;

Related Mesh Headings: Genes, Reporter;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G02.111.570.080.689.675; G05.360.080.689.675; G05.360.340.024.340.137.750.680;

History Note: 2009 (1985); for PROMOTER, GENETIC use OPERON 1980-1984; for rRNA PROMOTER use rRNA OPERON 1990-1998