Propanolamines - Pharmacokinetics
Research News and Information

Tuesday, November 24, 2009

Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers.

30 Aug 2009 1. The objective of this study was to investigate the effect of concomitantly administered silymarin on the pharmacokinetics of talinolol, a typical substrate for P-glycoprotein (P-gp), in healthy Chinese volunteers and its association with a ... Read more...

Ligand entry and exit pathways in the beta2-adrenergic receptor.

4 Aug 2009 The recently determined crystal structure of the human beta(2)-adrenergic (beta(2)AR) G-protein-coupled receptor provides an excellent structural basis for exploring beta(2)AR-ligand binding and dissociation process. Based on this crystal structure, ... Read more...

An improved primary human nasal cell culture for the simultaneous determination of transepithelial transport and ciliary beat frequency.

29 Jun 2009 OBJECTIVES: The aim was to establish a preclinical in-vitro system of the nasal mucosa for the simultaneous evaluation of nasal absorption and effects on ciliary activity. METHODS: Human nasal epithelial cells were grown in collagen-coated transport ... Read more...

Latest indexed articles for 'Propanolamines - Pharmacokinetics'

These are the very latest articles for this heading:

• Effect of continuous silymarin administration on oral talinolol pharmacokinetics in healthy volunteers. 30 Aug 2009
• Ligand entry and exit pathways in the beta2-adrenergic receptor. 4 Aug 2009
• An improved primary human nasal cell culture for the simultaneous determination of transepithelial transport and ciliary beat frequency. 29 Jun 2009
• Simulations of the nonlinear dose dependence for substrates of influx and efflux transporters in the human intestine. 10 May 2009
• Role of carvedilol controlled-release in cardiovascular disease. 29 Apr 2009
• Effects of Ginkgo biloba extract ingestion on the pharmacokinetics of talinolol in healthy Chinese volunteers. 26 Apr 2009
• Effect of poloxamer 188 on lymphatic uptake of carvedilol-loaded solid lipid nanoparticles for bioavailability enhancement. 30 Mar 2009
• Effect of Schisandra chinensis extract and Ginkgo biloba extract on the pharmacokinetics of talinolol in healthy volunteers. 27 Feb 2009
• Effect of Asparagus racemosus extract on transdermal delivery of carvedilol: a mechanistic study. 22 Feb 2009
• Route of penetration of topically instilled nipradilol into the ipsilateral posterior retina. 12 Feb 2009
• Comparison of the pharmacokinetic properties of bisoprolol and carvedilol in healthy dogs. 29 Nov 2008
• Concentration-dependent effect of naringin on intestinal absorption of beta(1)-adrenoceptor antagonist talinolol mediated by p-glycoprotein and organic anion transporting polypeptide (Oatp). 10 Nov 2008
• Development of carvedilol transdermal patches: evaluation of physicochemical, ex vivo and mechanical properties. 30 Oct 2008
• Is urethane-chloralose anaesthesia appropriate for pharmacokinetic-pharmacodynamic assessment? Studies with carvedilol. 30 Oct 2008
• Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists. 23 Sep 2008
• Transdermal delivery of carvedilol containing glycyrrhizin and chitosan as permeation enhancers: biochemical, biophysical, microscopic and pharmacodynamic evaluation. 30 Aug 2008
• Synthesis and preliminary evaluation of [(18)F]-fluoro-(2S)-Exaprolol for imaging cerebral beta-adrenergic receptors with PET. 14 Jul 2008
• In vitro permeation of carvedilol through porcine skin: effect of vehicles and penetration enhancers. 29 Jun 2008
• Design and in vivo evaluation of carvedilol buccal mucoadhesive patches. 29 Jun 2008
• Stereoselective analysis of carvedilol in human plasma and urine using HPLC after chiral derivatization. 29 Jun 2008

See a longer list of these articles.

Technical information about 'Propanolamines'

Definition: AMINO ALCOHOLS containing the propanolamine (NH2CH2CHOHCH2) group and its derivatives.

Registry Number: 0

Descriptor UI: D011412

Alternative terms: Propanolamines; Aminopropanols;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.033.100.624; D02.033.755.624; D02.092.063.624;

History Note: 74