Proteasome Endopeptidase Complex - Metabolism
Research News and Information

Monday, November 23, 2009

Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfbeta in osteosarcoma cells.

29 Nov 2009 Bone formation and osteoblast differentiation require the functional expression of the Runx2/Cbfbeta heterodimeric transcription factor complex. Runx2 is also a suppressor of proliferation in osteoblasts by attenuating cell cycle progression in ... Read more...

Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD.

10 Oct 2009 Unwanted proteins in the endoplasmic reticulum (ER) are exported into the cytoplasm and degraded by the proteasome through the ER-associated protein degradation pathway (ERAD). Disturbances in ERAD are linked to ER stress, which has been implicated ... Read more...

Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target.

4 Oct 2009 Multiple myeloma (MM) remains incurable despite novel therapies, suggesting the need for further identification of factors mediating tumorigenesis and drug resistance. Using both in vitro and in vivo MM xenograft models, we show that plasmacytoid ... Read more...

Latest indexed articles for 'Proteasome Endopeptidase Complex - Metabolism'

These are the very latest articles for this heading:

• Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfbeta in osteosarcoma cells. 29 Nov 2009
• Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. 10 Oct 2009
• Functional interaction of plasmacytoid dendritic cells with multiple myeloma cells: a therapeutic target. 4 Oct 2009
• Overexpression of the novel F-box protein Ymr258c confers resistance to methylmercury in Saccharomyces cerevisiae. 29 Sep 2009
• Biochemical consequences of sedlin mutations that cause spondyloepiphyseal dysplasia tarda. 23 Sep 2009
• The 20S proteasome as an assembly platform for the 19S regulatory complex. 21 Sep 2009
• Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. 14 Sep 2009
• Inhibitors selective for mycobacterial versus human proteasomes. 14 Sep 2009
• A distinct structural region of the prokaryotic ubiquitin-like protein (Pup) is recognized by the N-terminal domain of the proteasomal ATPase Mpa. 13 Sep 2009
• Markers of autophagy are downregulated in failing human heart after mechanical unloading. 13 Sep 2009
• Therapeutic use of tea derivatives: all that glitters is not gold. 8 Sep 2009
• Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition. 8 Sep 2009
• Interferon-gamma bolsters CD95/Fas-mediated apoptosis of astroglioma cells. 7 Sep 2009
• The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions. 31 Aug 2009
• The water channel aquaporin-1 partitions into exosomes during reticulocyte maturation: implication for the regulation of cell volume. 30 Aug 2009
• Less Smad2 is good for you! A scientific update on coffee's liver benefits. 30 Aug 2009
• Involvement of the mitochondrial pathway in p53-independent apoptosis induced by p28GANK knockdown in Hep3B cells. 29 Aug 2009
• Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation. 26 Aug 2009
• Negative action of hepatocyte growth factor/c-Met system on angiotensin II signaling via ligand-dependent epithelial growth factor receptor degradation mechanism in vascular smooth muscle cells. 25 Aug 2009
• A phase II evaluation of bortezomib in the treatment of recurrent platinum-sensitive ovarian or primary peritoneal cancer: a Gynecologic Oncology Group study. 24 Aug 2009

See a longer list of these articles.

Technical information about 'Proteasome Endopeptidase Complex'

Definition: A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.

Registry Number: EC 3.4.25.1

Descriptor UI: D046988

Alternative terms: Proteasome Endopeptidase Complex; Complex, Proteasome Endopeptidase; Endopeptidase Complex, Proteasome; Macropain; Macroxyproteinase; Multicatalytic Proteinase; Proteinase, Multicatalytic; Prosome; Proteasome; 20S Proteasome; Proteasome, 20S; Multicatalytic Endopeptidase Complex; Complex, Multicatalytic Endopeptidase; Endopeptidase Complex, Multicatalytic; Ingensin;

Related Mesh Headings: Ubiquitin-Protein Ligase Complexes;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D05.500.562.500; D08.811.277.656.918; D08.811.600.730;

History Note: 2005; use PROTEASOME ENDOPEPTIDASE COMPLEX (NM) 1986-2004