Protein Binding - Drug effects
Research News and Information

Monday, November 23, 2009

Expression of RIZ1 protein (Retinoblastoma-interacting zinc-finger protein 1) in prostate cancer epithelial cells changes with cancer grade progression and is modulated in vitro by DHT and E2.

29 Nov 2009 The nuclear protein methyl-transferase Retinoblastoma-interacting zinc-finger protein 1 (RIZ1) is considered to be a downstream effector of estrogen action in target tissues. Silencing of RIZ1 expression is common in many tumors. We analyzed RIZ1 ... Read more...

Requirement of a dynein light chain in TGFbeta/Smad3 signaling.

29 Nov 2009 We have previously reported that the dynein light chain (DLC) km23-1 is required for Smad2-dependent TGFbeta signaling. Here we describe another member of the km23/DYNLRB/LC7/robl family of DLCs, termed km23-2, which is also involved in TGFbeta ... Read more...

Characterization and structure of the manganese-responsive transcriptional regulator ScaR.

Nov 2009 The streptococcal coaggregation regulator (ScaR) of Streptococcus gordonii is a manganese-dependent transcriptional regulator. When intracellular manganese concentrations become elevated, ScaR represses transcription of the scaCBA operon, which ... Read more...

Latest indexed articles for 'Protein Binding - Drug effects'

These are the very latest articles for this heading:

• Expression of RIZ1 protein (Retinoblastoma-interacting zinc-finger protein 1) in prostate cancer epithelial cells changes with cancer grade progression and is modulated in vitro by DHT and E2. 29 Nov 2009
• Requirement of a dynein light chain in TGFbeta/Smad3 signaling. 29 Nov 2009
• Characterization and structure of the manganese-responsive transcriptional regulator ScaR. Nov 2009
• Leptin attenuates hypoxia/reoxygenation-induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells. 30 Oct 2009
• Dys-regulated activation of a Src tyroine kinase Hck at the Golgi disturbs N-glycosylation of a cytokine receptor Fms. 30 Oct 2009
• Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells. 17 Oct 2009
• Gal4 turnover and transcription activation. 6 Oct 2009
• Ir-CPI, a coagulation contact phase inhibitor from the tick Ixodes ricinus, inhibits thrombus formation without impairing hemostasis. 3 Oct 2009
• Regulation of vascularization by hypoxia-inducible factor 1. 29 Sep 2009
• Glutamate agonist LY404,039 for treating schizophrenia has affinity for the dopamine D2(High) receptor. 29 Sep 2009
• The dopaminergic stabilizer ASP2314/ACR16 selectively interacts with D2(High) receptors. 29 Sep 2009
• In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand. 29 Sep 2009
• Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions. 29 Sep 2009
• Expression of angiogenic regulators, VEGF and leptin, is regulated by the EGF/PI3K/STAT3 pathway in colorectal cancer cells. 29 Sep 2009
• Characterization of small RNAs in aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB. 22 Sep 2009
• Role of M2, M3, and M4 muscarinic receptor subtypes in the spinal cholinergic control of nociception revealed using siRNA in rats. 21 Sep 2009
• The role of granulocyte-colony stimulating factor (G-CSF) in the healthy brain: a characterization of G-CSF-deficient mice. 14 Sep 2009
• Promoting assembly and bundling of FtsZ as a strategy to inhibit bacterial cell division: a new approach for developing novel antibacterial drugs. 12 Sep 2009
• Hypoxia reduces TGFbeta1-induced corneal keratocyte myofibroblast transformation. 9 Sep 2009
• A novel decoy that interrupts G93A-superoxide dismutase gain of interaction with malate dehydrogenase improves survival in an amyotrophic lateral sclerosis cell model. 8 Sep 2009

See a longer list of these articles.

Technical information about 'Protein Binding'

Definition: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Descriptor UI: D011485

Alternative terms: Protein Binding; Binding, Protein; Plasma Protein Binding Capacity;

Related Mesh Headings: Binding Sites; Carrier Proteins; Metalloproteins; Radioligand Assay; Thyroxine-Binding Proteins;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;

Tree Number: G02.111.087.680; G02.149.115.680; G03.495.800;

History Note: 70(66)

Technical Notes: NIM; restrict to the chem or metab binding mechanism; coord NIM with substance being bound /metab (IM) + specific protein /metab (IM); do not use with receptors terms unless the substance bound to the receptor is a protein & the binding mechanism is discussed; do not confuse with BINDING PROTEINS see CARRIER PROTEINS