Protein Folding
Research News and Information

Sunday, November 22, 2009

Salt dependence of an alpha-helical peptide folding energy landscapes.

15 Nov 2009 We used CD, UV resonance Raman spectroscopy, and molecular dynamics simulation to examine the impact of salts on the conformational equilibria and the Ramachandran Psi angle (un)folding Gibbs free energy landscape coordinate of a mainly polyalanine ... Read more...

Influence of aggregation propensity and stability on amyloid fibril formation as studied by Fourier transform infrared spectroscopy and two-dimensional COS analysis.

8 Nov 2009 Understanding the process of amyloidogenesis is important for the future treatment of misfolding-based diseases, such as Alzheimer's, spongiform encephalopathies, and other important disorders affecting humans. In this work, we have used one of the ... Read more...

Annexin A5 directly interacts with amyloidogenic proteins and reduces their toxicity.

8 Nov 2009 Protein misfolding is a central mechanism for the development of neurodegenerative diseases and type 2 diabetes mellitus. The accumulation of misfolded alpha-synuclein protein inclusions in the Lewy bodies of Parkinson's disease is thought to play a ... Read more...

Latest indexed articles for 'Protein Folding'

These are the very latest articles for this heading:

• Salt dependence of an alpha-helical peptide folding energy landscapes. 15 Nov 2009
• Influence of aggregation propensity and stability on amyloid fibril formation as studied by Fourier transform infrared spectroscopy and two-dimensional COS analysis. 8 Nov 2009
• Annexin A5 directly interacts with amyloidogenic proteins and reduces their toxicity. 8 Nov 2009
• Interactions of the acidic domain and SRF interacting motifs with the NKX3.1 homeodomain. 8 Nov 2009
• Role of tryptophan-tryptophan interactions in Trpzip beta-hairpin formation, structure, and stability. Nov 2009
• The periplasmic chaperone Skp facilitates targeting, insertion, and folding of OmpA into lipid membranes with a negative membrane surface potential. Nov 2009
• Single-molecule analysis of protein-free U2-U6 snRNAs. 30 Oct 2009
• Temperature-induced partially unfolded state of hUBF HMG Box-5: conformational and dynamic investigations of the Box-5 thermal intermediate ensemble. 30 Oct 2009
• A distance-dependent atomic knowledge-based potential and force for discrimination of native structures from decoys. 30 Oct 2009
• Template-free protein structure prediction and quality assessment with an all-atom free-energy model. 30 Oct 2009
• A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity. 21 Oct 2009
• Correctors enhance maturation of DeltaF508 CFTR by promoting interactions between the two halves of the molecule. 18 Oct 2009
• The stathmin-derived I19L peptide interacts with FtsZ and alters its bundling. 18 Oct 2009
• Intramolecular amide stacking and its competition with hydrogen bonding in a small foldamer. 12 Oct 2009
• Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. 10 Oct 2009
• X-ray free-electron lasers fire up. 6 Oct 2009
• Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes. 4 Oct 2009
• Understanding the basis for the association of apoE4 with Alzheimer's disease: opening the door for therapeutic approaches. 29 Sep 2009
• The outermost N-terminal region of tapasin facilitates folding of major histocompatibility complex class I. 29 Sep 2009
• Exploring the folding energy landscape of a series of designed consensus tetratricopeptide repeat proteins. 29 Sep 2009

See a longer list of these articles.

Technical information about 'Protein Folding'

Definition: A rapid biochemical reaction involved in the formation of proteins. It begins even before a protein has been completely synthesized and proceeds through discrete intermediates (primary, secondary, and tertiary structures) before the final structure (quaternary structure) is developed.

Descriptor UI: D017510

Alternative terms: Protein Folding; Folding, Protein; Foldings, Protein; Protein Foldings; Protein Folding, Globular; Folding, Globular Protein; Foldings, Globular Protein; Globular Protein Folding; Globular Protein Foldings; Protein Foldings, Globular;

Related Mesh Headings: Protein Conformation;

Allowable Qualifiers: drug effects; radiation effects;

Tree Number: G01.154.100.640; G01.595.100.640; G02.111.087.690; G02.149.115.690;

History Note: 93