Protein Isoforms - Chemistry
Research News and Information

Sunday, November 22, 2009

C-terminal region-dependent change of antibody-binding to the Eighth Reelin repeat reflects the signaling activity of Reelin.

30 Oct 2009 Reelin is a secreted glycoprotein that plays pivotal roles in the development and function of the brain, but how it activates downstream intracellular signaling is not fully understood. We have recently reported that the highly conserved C-terminal ... Read more...

NFAT proteins: emerging roles in cancer progression.

30 Oct 2009 The roles of nuclear factor of activated T cells (NFAT) transcription factors have been extensively studied in the immune system. However, ubiquitous expression of NFAT isoforms in mammalian tissues has recently been observed, and a role for these ... Read more...

Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms.

29 Sep 2009 Down Syndrome cell adhesion molecule (Dscam) genes encode neuronal cell recognition proteins of the immunoglobulin superfamily. In Drosophila, Dscam1 generates 19,008 different ectodomains by alternative splicing of three exon clusters, each ... Read more...

Latest indexed articles for 'Protein Isoforms - Chemistry'

These are the very latest articles for this heading:

• C-terminal region-dependent change of antibody-binding to the Eighth Reelin repeat reflects the signaling activity of Reelin. 30 Oct 2009
• NFAT proteins: emerging roles in cancer progression. 30 Oct 2009
• Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms. 29 Sep 2009
• Differential expression of two distinct functional isoforms of melanopsin (Opn4) in the mammalian retina. 28 Sep 2009
• Proteome analysis of biomarkers in the cerebrospinal fluid of neuromyelitis optica patients. 17 Aug 2009
• Structural studies of soybean calmodulin isoform 4 bound to the calmodulin-binding domain of tobacco mitogen-activated protein kinase phosphatase-1 provide insights into a sequential target binding mode. 8 Aug 2009
• Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism. 8 Aug 2009
• Identification of protein domains that control proton and calcium sensitivity of ASIC1a. 2 Aug 2009
• Wasp mastoparans follow the same mechanism as the cell-penetrating peptide transportan 10. 2 Aug 2009
• Arrestin2/clathrin interaction is regulated by key N- and C-terminal regions in arrestin2. 2 Aug 2009
• Functional analysis of the posttranslational modifications of the death receptor 6. Aug 2009
• Structural and functional diversity of novel coronin 1C (CRN2) isoforms in muscle. Aug 2009
• Equine alpha S1-casein: characterization of alternative splicing isoforms and determination of phosphorylation levels. 30 Jul 2009
• CD44 variant isoforms in head and neck squamous cell carcinoma progression. 30 Jul 2009
• Binding of divalent cations is essential for the activity of the organellar peptidasome in Arabidopsis thaliana, AtPreP. 26 Jul 2009
• Characterisation of urokinase plasminogen activator receptor variants in human airway and peripheral cells. 26 Jul 2009
• p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. 25 Jul 2009
• Channel-like NH3 flux by ammonium transporter AtAMT2. 23 Jul 2009
• Rapid formin-mediated actin-filament elongation is essential for polarized plant cell growth. 22 Jul 2009
• Alternative splicing of G protein-coupled receptors: physiology and pathophysiology. 21 Jul 2009

See a longer list of these articles.

Technical information about 'Protein Isoforms'

Definition: Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.

Registry Number: 0

Descriptor UI: D020033

Alternative terms: Protein Isoforms; Isoforms, Protein; Isoforms; Splice Variants, Protein; Variants, Protein Splice; Protein Splice Variants;

Related Mesh Headings: Alternative Splicing; RNA Splice Sites;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.800;

History Note: 99

Technical Notes: IM general only; coordinate NIM with specific protein (IM); for enzymes use ISOENZYMES