Protein Isoforms - Genetics
Research News and Information

Sunday, November 22, 2009

Requirement of a dynein light chain in TGFbeta/Smad3 signaling.

29 Nov 2009 We have previously reported that the dynein light chain (DLC) km23-1 is required for Smad2-dependent TGFbeta signaling. Here we describe another member of the km23/DYNLRB/LC7/robl family of DLCs, termed km23-2, which is also involved in TGFbeta ... Read more...

C-terminal region-dependent change of antibody-binding to the Eighth Reelin repeat reflects the signaling activity of Reelin.

30 Oct 2009 Reelin is a secreted glycoprotein that plays pivotal roles in the development and function of the brain, but how it activates downstream intracellular signaling is not fully understood. We have recently reported that the highly conserved C-terminal ... Read more...

NFAT proteins: emerging roles in cancer progression.

30 Oct 2009 The roles of nuclear factor of activated T cells (NFAT) transcription factors have been extensively studied in the immune system. However, ubiquitous expression of NFAT isoforms in mammalian tissues has recently been observed, and a role for these ... Read more...

Latest indexed articles for 'Protein Isoforms - Genetics'

These are the very latest articles for this heading:

• Requirement of a dynein light chain in TGFbeta/Smad3 signaling. 29 Nov 2009
• C-terminal region-dependent change of antibody-binding to the Eighth Reelin repeat reflects the signaling activity of Reelin. 30 Oct 2009
• NFAT proteins: emerging roles in cancer progression. 30 Oct 2009
• ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses. 27 Oct 2009
• STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death. 18 Oct 2009
• Modulation of vitamin d receptor activity by the corepressor hairless: differential effects of hairless isoforms. 7 Oct 2009
• Bleeding in the brain: Amyloid-beta may keep clots away. 29 Sep 2009
• Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms. 29 Sep 2009
• Differential expression of two distinct functional isoforms of melanopsin (Opn4) in the mammalian retina. 28 Sep 2009
• Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice. 23 Sep 2009
• Identification of the amniotic fluid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms. 15 Sep 2009
• Expression of cadherin 23 isoforms is not conserved: implications for a mouse model of Usher syndrome type 1D. 10 Sep 2009
• Regulated expression of the alpha isoform of the human thromboxane A2 receptor during megakaryocyte differentiation: a coordinated role for WT1, Egr1, and Sp1. 6 Sep 2009
• Transcription variants of the prostate-specific PrLZ gene and their interaction with 14-3-3 proteins. 31 Aug 2009
• DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms. 31 Aug 2009
• An isoform-specific mutant reveals a role of PDP1 epsilon in the circadian oscillator. 31 Aug 2009
• IL-10 production by B cells expressing CD5 with the alternative exon 1B. 30 Aug 2009
• Tumour suppression by p53: the importance of apoptosis and cellular senescence. 30 Aug 2009
• Cyclic force upregulates mechano-growth factor and elevates cell proliferation in 3D cultured skeletal myoblasts. 27 Aug 2009
• Mutations of the FHL1 gene cause Emery-Dreifuss muscular dystrophy. 25 Aug 2009

See a longer list of these articles.

Technical information about 'Protein Isoforms'

Definition: Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.

Registry Number: 0

Descriptor UI: D020033

Alternative terms: Protein Isoforms; Isoforms, Protein; Isoforms; Splice Variants, Protein; Variants, Protein Splice; Protein Splice Variants;

Related Mesh Headings: Alternative Splicing; RNA Splice Sites;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.800;

History Note: 99

Technical Notes: IM general only; coordinate NIM with specific protein (IM); for enzymes use ISOENZYMES