Protein Isoforms
Research News and Information

Saturday, November 21, 2009

Requirement of a dynein light chain in TGFbeta/Smad3 signaling.

29 Nov 2009 We have previously reported that the dynein light chain (DLC) km23-1 is required for Smad2-dependent TGFbeta signaling. Here we describe another member of the km23/DYNLRB/LC7/robl family of DLCs, termed km23-2, which is also involved in TGFbeta ... Read more...

Differential oncogenic potential of geographically distinct Helicobacter pylori CagA isoforms in mice.

29 Nov 2009 Infection with cagA-positive Helicobacter pylori is associated with gastric carcinoma. The cagA-encoded CagA protein is delivered into gastric epithelial cells and, upon tyrosine phosphorylation at the C-terminal EPIYA segments, binds and ... Read more...

C-terminal region-dependent change of antibody-binding to the Eighth Reelin repeat reflects the signaling activity of Reelin.

30 Oct 2009 Reelin is a secreted glycoprotein that plays pivotal roles in the development and function of the brain, but how it activates downstream intracellular signaling is not fully understood. We have recently reported that the highly conserved C-terminal ... Read more...

Latest indexed articles for 'Protein Isoforms'

These are the very latest articles for this heading:

• Requirement of a dynein light chain in TGFbeta/Smad3 signaling. 29 Nov 2009
• Differential oncogenic potential of geographically distinct Helicobacter pylori CagA isoforms in mice. 29 Nov 2009
• C-terminal region-dependent change of antibody-binding to the Eighth Reelin repeat reflects the signaling activity of Reelin. 30 Oct 2009
• Identification of alternate transcripts of neuronal nitric oxide synthase in the mouse retina. 30 Oct 2009
• NFAT proteins: emerging roles in cancer progression. 30 Oct 2009
• ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses. 27 Oct 2009
• STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death. 18 Oct 2009
• The ARH adaptor protein regulates endocytosis of the ROMK potassium secretory channel in mouse kidney. 17 Oct 2009
• Modulation of vitamin d receptor activity by the corepressor hairless: differential effects of hairless isoforms. 7 Oct 2009
• Phosphorylation of the human microRNA-generating complex mediates MAPK/Erk signaling. 30 Sep 2009
• Bleeding in the brain: Amyloid-beta may keep clots away. 29 Sep 2009
• Aquaporin-4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodies. 29 Sep 2009
• Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms. 29 Sep 2009
• Cyclin D1b variant promotes cell invasiveness independent of binding to CDK4 in human bladder cancer cells. 29 Sep 2009
• Profile of exosomes related proteins released by differentiated and undifferentiated human keratinocytes. 29 Sep 2009
• Differential expression of two distinct functional isoforms of melanopsin (Opn4) in the mammalian retina. 28 Sep 2009
• Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice. 23 Sep 2009
• Identification of the amniotic fluid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms. 15 Sep 2009
• Human mast cells adhere to and migrate on epithelial and vascular basement membrane laminins LM-332 and LM-511 via alpha3beta1 integrin. 12 Sep 2009
• Coassembly of Mgm1 isoforms requires cardiolipin and mediates mitochondrial inner membrane fusion. 12 Sep 2009

See a longer list of these articles.

Technical information about 'Protein Isoforms'

Definition: Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.

Registry Number: 0

Descriptor UI: D020033

Alternative terms: Protein Isoforms; Isoforms, Protein; Isoforms; Splice Variants, Protein; Variants, Protein Splice; Protein Splice Variants;

Related Mesh Headings: Alternative Splicing; RNA Splice Sites;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.800;

History Note: 99

Technical Notes: IM general only; coordinate NIM with specific protein (IM); for enzymes use ISOENZYMES