Protein Kinase C-alpha - Genetics
Research News and Information

Sunday, November 22, 2009

Negative regulation of endogenous protein kinase Calpha on the dynamic change of carbachol-induced intracellular calcium response in different melanoma cells.

30 Oct 2009 Regulations of intracellular protein kinase C (PKC) on carbachol (CCh)-induced intracellular calcium ([Ca(2+)]i) responses were investigated in different stages of melanoma cells. We found that CCh (1 mM) significantly increased [Ca(2+)]i with 6-, ... Read more...

Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation.

21 Oct 2009 The Rnd proteins (Rnd1, Rnd2 and Rnd3/RhoE) form a distinct branch of the Rho family of small GTPases. Altered Rnd3 expression causes changes in cytoskeletal organization and cell cycle progression. Rnd3 functions to decrease RhoA activity, but how ... Read more...

Regulation of folate receptor internalization by protein kinase C alpha.

30 Aug 2009 The glycosyl-phosphatidylinositol anchored folate receptor (FR) mediates selective delivery of a broad range of experimental drugs to the receptor-rich tumors, but molecular mechanisms controlling FR internalization have not been adequately studied. ... Read more...

Latest indexed articles for 'Protein Kinase C-alpha - Genetics'

These are the very latest articles for this heading:

• Negative regulation of endogenous protein kinase Calpha on the dynamic change of carbachol-induced intracellular calcium response in different melanoma cells. 30 Oct 2009
• Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation. 21 Oct 2009
• Regulation of folate receptor internalization by protein kinase C alpha. 30 Aug 2009
• Breviscapine ameliorates hypertrophy of cardiomyocytes induced by high glucose in diabetic rats via the PKC signaling pathway. 11 Jul 2009
• Mutation of protein kinase C phosphorylation site S1076 on alpha-subunits affects BK(Ca) channel activity in HEK-293 cells. 8 Jul 2009
• PRKCA: a positional candidate gene for body mass index and asthma. 30 Jun 2009
• Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells. 29 Jun 2009
• Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach. 23 Jun 2009
• Protein kinase C alpha-specific peptide substrate graft-type copolymer for cancer cell-specific gene regulation systems. 19 Jun 2009
• A new mechanism of SOX9 action to regulate PKCalpha expression in the intestine epithelium. 7 Jun 2009
• Reduced l-arginine transport and nitric oxide synthesis in human umbilical vein endothelial cells from intrauterine growth restriction pregnancies is not further altered by hypoxia. 5 Jun 2009
• Knockout of the predominant conventional PKC isoform, PKCalpha, in mouse skeletal muscle does not affect contraction-stimulated glucose uptake. 17 May 2009
• Protein kinase Calpha-responsive polymeric carrier: its application for gene delivery into human cancers. 11 May 2009
• Activation of protein kinase Calpha by EPAC1 is required for the ERK- and CCAAT/enhancer-binding protein beta-dependent induction of the SOCS-3 gene by cyclic AMP in COS1 cells. 5 May 2009
• Epithelial-to-mesenchymal transition and resistance to ingenol 3-angelate, a novel protein kinase C modulator, in colon cancer cells. 3 May 2009
• Protein kinase C in porcine retinal arteries and neuroretina following retinal ischemia-reperfusion. 11 Apr 2009
• Role for protein kinase C-alpha in keratinocyte growth arrest. 31 Mar 2009
• IL-1 beta induces urokinase-plasminogen activator expression and cell migration through PKC alpha, JNK1/2, and NF-kappaB in A549 cells. 30 Mar 2009
• Antisense expression of PKCalpha improved sensitivity of SGC7901/VCR cells to doxorubicin. 12 Mar 2009
• Activation of protein kinase C{eta} by type I interferons. 9 Feb 2009

See a longer list of these articles.

Technical information about 'Protein Kinase C-alpha'

Definition: A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells.

Registry Number: EC 2.7.1.37

Descriptor UI: D051571

Alternative terms: Protein Kinase C-alpha; Protein Kinase C alpha; Protein Kinase C(alpha); PKC-alpha Serine-Threonine Kinase; PKC alpha Serine Threonine Kinase; Serine-Threonine Kinase, PKC-alpha;

Allowable Qualifiers: diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency;

Tree Number: D08.811.913.696.620.682.700.725.100;

History Note: 2006(1999)