Protein Kinase C-alpha
Research News and Information

Sunday, November 22, 2009

Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis.

29 Nov 2009 Endometrial cancer is the most common invasive gynecologic malignancy, yet molecular mechanisms and signaling pathways underlying its etiology and pathophysiology remain poorly characterized. We sought to define a functional role for the protein ... Read more...

Negative regulation of endogenous protein kinase Calpha on the dynamic change of carbachol-induced intracellular calcium response in different melanoma cells.

30 Oct 2009 Regulations of intracellular protein kinase C (PKC) on carbachol (CCh)-induced intracellular calcium ([Ca(2+)]i) responses were investigated in different stages of melanoma cells. We found that CCh (1 mM) significantly increased [Ca(2+)]i with 6-, ... Read more...

Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation.

21 Oct 2009 The Rnd proteins (Rnd1, Rnd2 and Rnd3/RhoE) form a distinct branch of the Rho family of small GTPases. Altered Rnd3 expression causes changes in cytoskeletal organization and cell cycle progression. Rnd3 functions to decrease RhoA activity, but how ... Read more...

Latest indexed articles for 'Protein Kinase C-alpha'

These are the very latest articles for this heading:

• Protein kinase C alpha-dependent signaling mediates endometrial cancer cell growth and tumorigenesis. 29 Nov 2009
• Negative regulation of endogenous protein kinase Calpha on the dynamic change of carbachol-induced intracellular calcium response in different melanoma cells. 30 Oct 2009
• Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation. 21 Oct 2009
• Protein kinase Calpha puts the hand cuffs on epidermal keratinocyte proliferation. 29 Sep 2009
• Titin phosphorylation: myocardial passive stiffness regulated by the intracellular giant. 23 Sep 2009
• Immunohistochemical study of pig retinal development. 19 Sep 2009
• Regulation of the substrate preference of p190RhoGAP by protein kinase C-mediated phosphorylation of a phospholipid binding site. 13 Sep 2009
• Galantamine enhancement of long-term potentiation is mediated by calcium/calmodulin-dependent protein kinase II and protein kinase C activation. 30 Aug 2009
• Regulation of folate receptor internalization by protein kinase C alpha. 30 Aug 2009
• Tyrosine and serine phosphorylation regulate the conformation and subsequent threonine phosphorylation of the L1 cytoplasmic domain. 27 Aug 2009
• Cigarette smoke extract induces COX-2 expression via a PKCalpha/c-Src/EGFR, PDGFR/PI3K/Akt/NF-kappaB pathway and p300 in tracheal smooth muscle cells. 26 Aug 2009
• Oxalate-induced activation of PKC-alpha and -delta regulates NADPH oxidase-mediated oxidative injury in renal tubular epithelial cells. 17 Aug 2009
• PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness. 11 Aug 2009
• Differential CRX and OTX2 expression in human retina and retinoblastoma. Aug 2009
• Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling. Aug 2009
• Activation of rapid signaling pathways does not contribute to 1 alpha,25-dihydroxyvitamin D3-induced growth inhibition of mouse prostate epithelial progenitor cells. 30 Jul 2009
• Regulation of plasminogen activator inhibitor 1 expression in human osteoarthritic chondrocytes by fluid shear stress: role of protein kinase Calpha. 30 Jul 2009
• Activated PKCalpha/ERK1/2 signaling inhibits tamoxifen-induced apoptosis in C6 cells. 30 Jul 2009
• Role of iduronate-2-sulfatase in glucose-stimulated insulin secretion by activation of exocytosis. 12 Jul 2009
• Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors. 12 Jul 2009

See a longer list of these articles.

Technical information about 'Protein Kinase C-alpha'

Definition: A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells.

Registry Number: EC 2.7.1.37

Descriptor UI: D051571

Alternative terms: Protein Kinase C-alpha; Protein Kinase C alpha; Protein Kinase C(alpha); PKC-alpha Serine-Threonine Kinase; PKC alpha Serine Threonine Kinase; Serine-Threonine Kinase, PKC-alpha;

Allowable Qualifiers: diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency;

Tree Number: D08.811.913.696.620.682.700.725.100;

History Note: 2006(1999)