Protein Kinases
Research News and Information

Monday, November 23, 2009

Lipid raft-targeted Akt promotes axonal branching and growth cone expansion via mTOR and Rac1, respectively.

30 Oct 2009 The molecular mechanisms by which extracellular guidance cues regulate axonal morphology are not fully understood. Recent findings suggest that increased activity of the protein kinase Akt promotes dendritic branching and elongation in hippocampal ... Read more...

Diallyl trisulfide-induced apoptosis in human cancer cells is linked to checkpoint kinase 1-mediated mitotic arrest.

30 Oct 2009 Growth suppressive effect of diallyl trisulfide (DATS), a promising cancer chemopreventive constituent of garlic, against cultured human cancer cells correlates with checkpoint kinase 1 (Chk1)-mediated mitotic arrest, but the fate of the cells ... Read more...

Targeting protein kinases in central nervous system disorders.

30 Oct 2009 Protein kinases are a growing drug target class in disorders in peripheral tissues, but the development of kinase-targeted therapies for central nervous system (CNS) diseases remains a challenge, largely owing to issues associated specifically with ... Read more...

Latest indexed articles for 'Protein Kinases'

These are the very latest articles for this heading:

• Lipid raft-targeted Akt promotes axonal branching and growth cone expansion via mTOR and Rac1, respectively. 30 Oct 2009
• Diallyl trisulfide-induced apoptosis in human cancer cells is linked to checkpoint kinase 1-mediated mitotic arrest. 30 Oct 2009
• Targeting protein kinases in central nervous system disorders. 30 Oct 2009
• Leptin attenuates hypoxia/reoxygenation-induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells. 30 Oct 2009
• Muscle contractions guide rohon-beard peripheral sensory axons. 19 Oct 2009
• Characterization of the CHK1 allosteric inhibitor binding site. 18 Oct 2009
• Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases. 14 Oct 2009
• A view to a kill: how ligand quality controls lethal hits. 14 Oct 2009
• mTOR signaling in epileptogenesis: too much of a good thing? 5 Oct 2009
• Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis. 3 Oct 2009
• Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. 30 Sep 2009
• Cell signaling. Aging is RSKy business. 30 Sep 2009
• Transcriptional control of the inflammatory response. 29 Sep 2009
• Mechanisms of mast cell signaling in anaphylaxis. 29 Sep 2009
• DNA damage checkpoint maintains CDH1 in an active state to inhibit anaphase progression. 29 Sep 2009
• Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis. 29 Sep 2009
• Crystal structure of a histidine kinase sensor domain with similarity to periplasmic binding proteins. 29 Sep 2009
• Resistance to targeted therapy in renal-cell carcinoma. 29 Sep 2009
• Focal brain malformations: seizures, signaling, sequencing. 29 Sep 2009
• Involvement of ATM-mediated Chk1/2 and JNK kinase signaling activation in HKH40A-induced cell growth inhibition. 29 Sep 2009

See a longer list of these articles.

Technical information about 'Protein Kinases'

Definition: A family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein. EC 2.7.1.37.

Chemical name: ATP-protein phosphotransferase

Registry Number: EC 2.7.1.37

Descriptor UI: D011494

Alternative terms: Protein Kinases; Kinases, Protein; Protein Kinase; Kinase, Protein;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.913.696.620.682;

Online Note: use PROTEIN KINASES to search PROTEIN KINASE 1973-79 (as Prov 1973)

History Note: 80; was PROTEIN KINASE 1973-79 (Prov 1973)