Protein-Serine-Threonine Kinases
Research News and Information

Sunday, November 22, 2009

Requirement of a dynein light chain in TGFbeta/Smad3 signaling.

29 Nov 2009 We have previously reported that the dynein light chain (DLC) km23-1 is required for Smad2-dependent TGFbeta signaling. Here we describe another member of the km23/DYNLRB/LC7/robl family of DLCs, termed km23-2, which is also involved in TGFbeta ... Read more...

Kinetic studies of HPr, HPr(H15D), HPr(H15E), and HPr(His approximately P) phosphorylation by the Streptococcus salivarius HPr(Ser) kinase/phosphorylase.

15 Nov 2009 HPr is a central protein of the phosphoenolpyruvate:sugar phosphotransferase transport system (PTS). In streptococci, HPr can be phosphorylated at His(15) at the expense of PEP by enzyme I (EI) of the PTS, producing HPr(His approximately P). HPr can ... Read more...

The reduction of cell death and proliferation by p27(Kip1) minimizes DNA damage in an experimental model of genotoxicity.

13 Nov 2009 Hepatocellular carcinoma (HCC) is the fifth most commonly occurring cancer worldwide. The expression of p27 has been related to reduced severity of tumor grade and recurrence of HCC. The study assessed the role of p27 on the cell proliferation and ... Read more...

Latest indexed articles for 'Protein-Serine-Threonine Kinases'

These are the very latest articles for this heading:

• Requirement of a dynein light chain in TGFbeta/Smad3 signaling. 29 Nov 2009
• Kinetic studies of HPr, HPr(H15D), HPr(H15E), and HPr(His approximately P) phosphorylation by the Streptococcus salivarius HPr(Ser) kinase/phosphorylase. 15 Nov 2009
• The reduction of cell death and proliferation by p27(Kip1) minimizes DNA damage in an experimental model of genotoxicity. 13 Nov 2009
• Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis. 2 Nov 2009
• Kinetic mechanism and inhibitor characterization of WNK1 kinase. Nov 2009
• Aurora B expression in post-puberal testicular germ cell tumours. 30 Oct 2009
• New biochemical approaches towards understanding the Parkinson's disease-associated kinase, LRRK2. 21 Oct 2009
• Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. 21 Oct 2009
• Conditions of endoplasmic reticulum stress stimulate lipid droplet formation in Saccharomyces cerevisiae. 21 Oct 2009
• TGFbetaR2 aberrant methylation is a potential prognostic marker and therapeutic target in multiple myeloma. 13 Oct 2009
• The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. 9 Oct 2009
• Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase. 6 Oct 2009
• Tim-Tipin dysfunction creates an indispensible reliance on the ATR-Chk1 pathway for continued DNA synthesis. 3 Oct 2009
• Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes. 3 Oct 2009
• CD8(+) T cells specific for beta cells encounter their cognate antigens in the islets of NOD mice. 29 Sep 2009
• DMPK protein isoforms are differentially expressed in myogenic and neural cell lineages. 29 Sep 2009
• DNA damage checkpoint maintains CDH1 in an active state to inhibit anaphase progression. 29 Sep 2009
• Chk2 protects against radiation-induced genomic instability. 29 Sep 2009
• Overexpression of Ycg1 or Ydr520c confers resistance to cadmium in Saccharomyces cerevisiae. 29 Sep 2009
• Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation. 29 Sep 2009

See a longer list of these articles.

Technical information about 'Protein-Serine-Threonine Kinases'

Definition: A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.

Registry Number: EC 2.7.11.1

Descriptor UI: D017346

Alternative terms: Protein-Serine-Threonine Kinases; Kinases, Protein-Serine-Threonine; Protein Serine Threonine Kinases; Protein-Serine-Threonine Kinase; Kinase, Protein-Serine-Threonine; Protein Serine Threonine Kinase; Protein-Threonine Kinase; Kinase, Protein-Threonine; Protein Threonine Kinase; Threonine Kinase; Kinase, Threonine; Serine-Threonine Kinase; Kinase, Serine-Threonine; Serine Threonine Kinase; Serine-Threonine Kinases; Kinases, Serine-Threonine; Serine Threonine Kinases; Serine-Threonine Protein Kinases; Kinases, Serine-Threonine Protein; Protein Kinases, Serine-Threonine; Serine Threonine Protein Kinases; Protein-Serine Kinase; Kinase, Protein-Serine; Protein Serine Kinase; Serine Kinase; Kinase, Serine;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.913.696.620.682.700;

Online Note: use PROTEIN-SERINE-THREONINE KINASES (NM) to search SERINE KINASE 1985-92 & PROTEIN-THREONINE KINASE 1983-92

History Note: 93; was SERINE KINASE (NM) 1985-92 & PROTEIN-THREONINE KINASE (NM) 1983-92