Protein Structure, Tertiary
Research News and Information

Monday, November 23, 2009

Periplasmic domains of Pseudomonas aeruginosa PilN and PilO form a stable heterodimeric complex.

18 Nov 2009 Type IV pili (T4P) are bacterial virulence factors responsible for attachment to surfaces and for twitching motility, a motion that involves a succession of pilus extension and retraction cycles. In the opportunistic pathogen Pseudomonas aeruginosa, ... Read more...

A flavin cofactor-binding PAS domain regulates c-di-GMP synthesis in AxDGC2 from Acetobacter xylinum.

Nov 2009 The cytoplasmic protein AxDGC2 regulates cellulose synthesis in the obligate aerobe Acetobacter xylinum by controlling the cellular concentration of the cyclic dinucleotide messenger c-di-GMP. AxDGC2 contains a Per-Arnt-Sim (PAS) domain and two ... Read more...

The membrane topography of the diphtheria toxin T domain linked to the a chain reveals a transient transmembrane hairpin and potential translocation mechanisms.

Nov 2009 The diphtheria toxin T domain helps translocate the A chain of the toxin across membranes. To gain insight into translocation, the membrane topography of key residues in T domain attached to the A chain (AT protein) was compared to that in the ... Read more...

Latest indexed articles for 'Protein Structure, Tertiary'

These are the very latest articles for this heading:

• Periplasmic domains of Pseudomonas aeruginosa PilN and PilO form a stable heterodimeric complex. 18 Nov 2009
• A flavin cofactor-binding PAS domain regulates c-di-GMP synthesis in AxDGC2 from Acetobacter xylinum. Nov 2009
• The membrane topography of the diphtheria toxin T domain linked to the a chain reveals a transient transmembrane hairpin and potential translocation mechanisms. Nov 2009
• Mutual exchange of kinetic properties by extended mutagenesis in two short LOV domain proteins from Pseudomonas putida. Nov 2009
• Regulation of a muralytic enzyme by dynamic membrane topology. 30 Oct 2009
• Targeted molecular dynamics reveals overall common conformational changes upon hybrid domain swing-out in beta3 integrins. 30 Oct 2009
• Characterization of cancer-linked BRCA1-BRCT missense variants and their interaction with phosphoprotein targets. 30 Oct 2009
• Native state dynamics and mechanical properties of human topoisomerase I within a structure-based coarse-grained model. 30 Oct 2009
• The Rho GTPase inactivation domain in Vibrio cholerae MARTX toxin has a circularly permuted papain-like thiol protease fold. 30 Oct 2009
• Modular coenzyme specificity: a domain-swopped chimera of glutamate dehydrogenase. 30 Oct 2009
• Substrate binding modifies the hinge bending characteristics of human 3-phosphoglycerate kinase: a molecular dynamics study. 30 Oct 2009
• Prion protein region 23-32 interacts with tubulin and inhibits microtubule assembly. 30 Oct 2009
• The capsid protein of human immunodeficiency virus: designing inhibitors of capsid assembly. 30 Oct 2009
• RAGE expression and NF-kappaB activation attenuated by extracellular domain of RAGE in human salivary gland cell line. 30 Oct 2009
• Granzyme A is a proinflammatory protease. 27 Oct 2009
• SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. 27 Oct 2009
• Runx proteins regulate Foxp3 expression. 17 Oct 2009
• Hsp90 charged-linker truncation reverses the functional consequences of weakened hydrophobic contacts in the N domain. 16 Oct 2009
• Chronic myeloid leukemia with p190BCR-ABL: prevalence, morphology, tyrosine kinase inhibitor response, and kinase domain mutation analysis. 13 Oct 2009
• Dengue virus NS5 inhibits interferon-alpha signaling by blocking signal transducer and activator of transcription 2 phosphorylation. 13 Oct 2009

See a longer list of these articles.

Technical information about 'Protein Structure, Tertiary'

Definition: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.

Descriptor UI: D017434

Alternative terms: Protein Structure, Tertiary; Tertiary Protein Structure; Protein Structures, Tertiary; Tertiary Protein Structures; Peptide Domain; Domain, Peptide; Domains, Peptide; Peptide Domains; Protein Domains; Domain, Protein; Domains, Protein; Protein Domain;

Allowable Qualifiers: drug effects; genetics; physiology; radiation effects;

Tree Number: G02.111.570.790.709.610;

History Note: 93

Technical Notes: IM general; coord NIM with specific protein (IM); PROTEIN MOTIFS see MOTIFS, AMINO ACID is available