Protein Transport - Physiology
Research News and Information

Monday, November 23, 2009

Rab22B is expressed in the CNS astroglia lineage and plays a role in epidermal growth factor receptor trafficking in A431 cells.

29 Nov 2009 The expression profile and functions of the brain-enriched Rab22B/Rab31 small GTPase had remained uncharacterized. Using specific antibodies against Rab22B, we found the protein to be exceptionally enriched in nestin and RC2-positive radial glia of ... Read more...

Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval.

29 Nov 2009 ClC-2 chloride channel is present in the brain and some transporting epithelia where its function is poorly understood. We have now demonstrated that the surface channels are rapidly internalised and approximately the 70% of the surface membrane ... Read more...

A nanomedicine transports a peptide caspase-3 inhibitor across the blood-brain barrier and provides neuroprotection.

2 Nov 2009 Caspases play an important role as mediators of cell death in acute and chronic neurological disorders. Although peptide inhibitors of caspases provide neuroprotection, they have to be administered intracerebroventricularly because they cannot cross ... Read more...

Latest indexed articles for 'Protein Transport - Physiology'

These are the very latest articles for this heading:

• Rab22B is expressed in the CNS astroglia lineage and plays a role in epidermal growth factor receptor trafficking in A431 cells. 29 Nov 2009
• Rapid recycling of ClC-2 chloride channels between plasma membrane and endosomes: role of a tyrosine endocytosis motif in surface retrieval. 29 Nov 2009
• A nanomedicine transports a peptide caspase-3 inhibitor across the blood-brain barrier and provides neuroprotection. 2 Nov 2009
• The periplasmic chaperone Skp facilitates targeting, insertion, and folding of OmpA into lipid membranes with a negative membrane surface potential. Nov 2009
• The membrane topography of the diphtheria toxin T domain linked to the a chain reveals a transient transmembrane hairpin and potential translocation mechanisms. Nov 2009
• Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking. 27 Oct 2009
• Intra-axonal patterning: intrinsic compartmentalization of the axonal membrane in Drosophila neurons. 27 Oct 2009
• SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. 27 Oct 2009
• Sun proteins enlighten nuclear movement in development. 27 Oct 2009
• Analysis of the dual function of the ESCRT-III protein Snf7 in endocytic trafficking and in gene expression. 21 Oct 2009
• The TC10-Exo70 complex is essential for membrane expansion and axonal specification in developing neurons. 19 Oct 2009
• Distinct domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking. 12 Oct 2009
• New insights in the biology of BDNF synthesis and release: implications in CNS function. 12 Oct 2009
• Angiopoietin-1-induced ubiquitylation of Tie2 by c-Cbl is required for internalization and degradation. 10 Oct 2009
• Mitochondrial BNIP3 upregulation precedes endonuclease G translocation in hippocampal neuronal death following oxygen-glucose deprivation. 6 Sep 2009
• T-cadherin is located in the nucleus and centrosomes in endothelial cells. 31 Aug 2009
• The inactivation of the sortilin gene leads to a partial disruption of prosaposin trafficking to the lysosomes. 31 Aug 2009
• The water channel aquaporin-1 partitions into exosomes during reticulocyte maturation: implication for the regulation of cell volume. 30 Aug 2009
• A dual role of the N-terminal FQQI motif in GLUT4 trafficking. 30 Aug 2009
• Polarized endocytic transport: the roles of Rab11 and Rab11-FIPs in regulating cell polarity. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Protein Transport'

Definition: The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.

Descriptor UI: D021381

Alternative terms: Protein Transport; Protein Transports; Protein Trafficking; Protein Traffickings; Trafficking, Protein; Traffickings, Protein; Gated Protein Transport; Protein Transport, Gated; Protein Targeting; Targeting, Protein; Protein Localization Processes, Cellular; Protein Translocation; Transmembrane Protein Transport; Protein Transport, Transmembrane; Transmembrane Protein Transports; Vesicular Protein Transport; Protein Transport, Vesicular; Protein Sorting; Protein Sortings;

Related Mesh Headings: Protein Sorting Signals;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;

Tree Number: G03.495.166.700;

History Note: 2001

Technical Notes: coordinate NIM with specific protein/metab (IM) or /pharmacokin (IM)