Proteins - Metabolism
Research News and Information

Sunday, November 22, 2009

Positive direct and indirect antiglobulin tests associated with oxaliplatin can be due to drug antibody and/or drug-induced nonimmunologic protein adsorption.

13 Dec 2009 BACKGROUND: Two patients were suspected of having immune hemolytic anemia (IHA) due to oxaliplatin. A related drug, cisplatin, is known to cause nonimmunologic protein adsorption (NIPA). Studies were performed to determine the presence of ... Read more...

RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells.

29 Nov 2009 RhoB, a tumor suppressor, has emerged as an interesting cancer target, and extensive studies aimed at understanding its role in apoptosis have been performed. In our study, we investigated the involvement of RhoB-interacting molecules in apoptosis. ... Read more...

Engineering protein stability and specificity using fluorous amino acids: the importance of packing effects.

15 Nov 2009 The incorporation of extensively fluorinated, or fluorous, analogues of hydrophobic amino acids into proteins potentially provides the opportunity to modulate the physicochemical properties of proteins in a predictable manner. On the basis of the ... Read more...

Latest indexed articles for 'Proteins - Metabolism'

These are the very latest articles for this heading:

• Positive direct and indirect antiglobulin tests associated with oxaliplatin can be due to drug antibody and/or drug-induced nonimmunologic protein adsorption. 13 Dec 2009
• RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells. 29 Nov 2009
• Engineering protein stability and specificity using fluorous amino acids: the importance of packing effects. 15 Nov 2009
• Effect of neutralizing antibodies on biomarker responses to interferon beta: the INSIGHT study. Nov 2009
• A more structured metabolome. 30 Oct 2009
• Evolution of biomolecular networks: lessons from metabolic and protein interactions. 30 Oct 2009
• Regulation of histidine-rich glycoprotein (HRG) function via plasmin-mediated proteolytic cleavage. 21 Oct 2009
• A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity. 21 Oct 2009
• Molybdenum trafficking for nitrogen fixation. 18 Oct 2009
• The optogenetic catechism. 14 Oct 2009
• Force and function: probing proteins with AFM-based force spectroscopy. 10 Oct 2009
• Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling. 10 Oct 2009
• The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. 9 Oct 2009
• Learning how to read ADP-ribosylation. 30 Sep 2009
• Impaired autophagic flux mediates acinar cell vacuole formation and trypsinogen activation in rodent models of acute pancreatitis. 29 Sep 2009
• FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins. 29 Sep 2009
• Prediction of protein-glucose binding sites using support vector machines. 29 Sep 2009
• Native secondary structure topology has near minimum contact energy among all possible geometrically constrained topologies. 29 Sep 2009
• Evolutionary conservation in multiple faces of protein interaction. 29 Sep 2009
• Accumulation of polyubiquitinated proteins by overexpression of RBCC protein interacting with protein kinase C2, a splice variant of ubiquitin ligase RBCC protein interacting with protein kinase C1. 29 Sep 2009

See a longer list of these articles.

Technical information about 'Proteins'

Definition: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.

Registry Number: 0

Descriptor UI: D011506

Alternative terms: Proteins; Gene Products, Protein; Protein Gene Products; Gene Proteins; Proteins, Gene;

Related Mesh Headings: Amino Acid Sequence; Blood Proteins; Protein Conformation;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; chemical synthesis; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; chemistry; contraindications; agonists;

Tree Number: D12.776;

Online Note: pre-explosion = PROTEINS (PX)

History Note: /metabolism was PROTEIN METABOLISM 1963-65; PROTEIN METABOLISM DISORDERS was heading 1963-64

Technical Notes: general only; prefer specific protein or specific precoordinated protein group terms such as EYE PROTEINS; BACTERIAL PROTEINS; DIETARY PROTEINS; etc.; primary protein structure = AMINO ACID SEQUENCE; protein structure referring to protein architecture = PROTEIN CONFORMATION or its specifics: PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; or PROTEIN STRUCTURE, QUATERNARY