Proteins
Research News and Information

Saturday, November 21, 2009

Positive direct and indirect antiglobulin tests associated with oxaliplatin can be due to drug antibody and/or drug-induced nonimmunologic protein adsorption.

13 Dec 2009 BACKGROUND: Two patients were suspected of having immune hemolytic anemia (IHA) due to oxaliplatin. A related drug, cisplatin, is known to cause nonimmunologic protein adsorption (NIPA). Studies were performed to determine the presence of ... Read more...

RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells.

29 Nov 2009 RhoB, a tumor suppressor, has emerged as an interesting cancer target, and extensive studies aimed at understanding its role in apoptosis have been performed. In our study, we investigated the involvement of RhoB-interacting molecules in apoptosis. ... Read more...

Compound heterozygous HAX1 mutations in a Swedish patient with severe congenital neutropenia and no neurodevelopmental abnormalities.

29 Nov 2009 Kostmann disease or severe congenital neutropenia (SCN) is an autosomal recessive disorder of neutrophil production. Homozygous HAX1 mutations were recently identified in SCN patients belonging to the original family in northern Sweden described by ... Read more...

Latest indexed articles for 'Proteins'

These are the very latest articles for this heading:

• Positive direct and indirect antiglobulin tests associated with oxaliplatin can be due to drug antibody and/or drug-induced nonimmunologic protein adsorption. 13 Dec 2009
• RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells. 29 Nov 2009
• Compound heterozygous HAX1 mutations in a Swedish patient with severe congenital neutropenia and no neurodevelopmental abnormalities. 29 Nov 2009
• Engineering protein stability and specificity using fluorous amino acids: the importance of packing effects. 15 Nov 2009
• Effect of neutralizing antibodies on biomarker responses to interferon beta: the INSIGHT study. Nov 2009
• A more structured metabolome. 30 Oct 2009
• Quantitative analysis and prediction of curvature in leucine-rich repeat proteins. 30 Oct 2009
• A distance-dependent atomic knowledge-based potential and force for discrimination of native structures from decoys. 30 Oct 2009
• Successful endobronchial seal of surgical bronchopleural fistulas using BioGlue. 30 Oct 2009
• More on Schnyder corneal dystrophy. 30 Oct 2009
• Evolution of biomolecular networks: lessons from metabolic and protein interactions. 30 Oct 2009
• Fam83h is associated with intracellular vesicles and ADHCAI. 30 Oct 2009
• Regulation of histidine-rich glycoprotein (HRG) function via plasmin-mediated proteolytic cleavage. 21 Oct 2009
• A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity. 21 Oct 2009
• Prostaglandin E2-induced masculinization of brain and behavior requires protein kinase A, AMPA/kainate, and metabotropic glutamate receptor signaling. 19 Oct 2009
• Molybdenum trafficking for nitrogen fixation. 18 Oct 2009
• The optogenetic catechism. 14 Oct 2009
• Mathematical modeling of elution curves for a protein mixture in ion exchange chromatography applied to high protein concentration. 13 Oct 2009
• Quadrupole-central-transition 17O NMR spectroscopy of protein-ligand complexes in solution. 12 Oct 2009
• One-sample approach to determine the relative orientations of proteins in ternary and binary complexes from residual dipolar coupling measurements. 12 Oct 2009

See a longer list of these articles.

Technical information about 'Proteins'

Definition: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.

Registry Number: 0

Descriptor UI: D011506

Alternative terms: Proteins; Gene Products, Protein; Protein Gene Products; Gene Proteins; Proteins, Gene;

Related Mesh Headings: Amino Acid Sequence; Blood Proteins; Protein Conformation;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; chemical synthesis; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; chemistry; contraindications; agonists;

Tree Number: D12.776;

Online Note: pre-explosion = PROTEINS (PX)

History Note: /metabolism was PROTEIN METABOLISM 1963-65; PROTEIN METABOLISM DISORDERS was heading 1963-64

Technical Notes: general only; prefer specific protein or specific precoordinated protein group terms such as EYE PROTEINS; BACTERIAL PROTEINS; DIETARY PROTEINS; etc.; primary protein structure = AMINO ACID SEQUENCE; protein structure referring to protein architecture = PROTEIN CONFORMATION or its specifics: PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; or PROTEIN STRUCTURE, QUATERNARY