Proteoglycans - Metabolism
Research News and Information

Monday, November 23, 2009

STAT3 activation contributes directly to Epstein-Barr virus-mediated invasiveness of nasopharyngeal cancer cells in vitro.

13 Oct 2009 Nasopharyngeal cancer (NPC) is an Epstein-Barr virus (EBV)-associated head and neck cancer prevalent in Asia. Although with reasons not fully understood, the intrinsic invasiveness of NPC is believed to be EBV-linked. Recently, EBV was found to ... Read more...

The core protein of glypican Dally-like determines its biphasic activity in wingless morphogen signaling.

29 Sep 2009 Dally-like (Dlp) is a glypican-type heparan sulfate proteoglycan (HSPG), containing a protein core and attached glycosaminoglycan (GAG) chains. In Drosophila wing discs, Dlp represses short-range Wingless (Wg) signaling, but activates long-range Wg ... Read more...

Does loading influence the severity of cartilage degeneration in the canine Groove-model of OA?

29 Sep 2009 Many animal models are used to study osteoarthritis (OA). In these models the role of joint loading in the development of OA is not fully understood. We studied the effect of loading on the development of OA in the canine Groove-model. In ten female ... Read more...

Latest indexed articles for 'Proteoglycans - Metabolism'

These are the very latest articles for this heading:

• STAT3 activation contributes directly to Epstein-Barr virus-mediated invasiveness of nasopharyngeal cancer cells in vitro. 13 Oct 2009
• The core protein of glypican Dally-like determines its biphasic activity in wingless morphogen signaling. 29 Sep 2009
• Does loading influence the severity of cartilage degeneration in the canine Groove-model of OA? 29 Sep 2009
• The glypican Dally is required in the niche for the maintenance of germline stem cells and short-range BMP signaling in the Drosophila ovary. 28 Sep 2009
• Vascular endothelial growth factor receptor-1 (VEGFR-1) expression in human corneal fibroblast decreased with age. 27 Sep 2009
• Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. 16 Sep 2009
• Anti-endoglin monoclonal antibodies are effective for suppressing metastasis and the primary tumors by targeting tumor vasculature. 13 Sep 2009
• Asporin competes with decorin for collagen binding, binds calcium and promotes osteoblast collagen mineralization. 12 Sep 2009
• Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. 6 Sep 2009
• B-type natriuretic peptide enhances vasculogenesis by promoting number and functional properties of early endothelial progenitor cells. 30 Aug 2009
• Paracrine effect of transplanted rib chondrocyte spheroids supports formation of secondary cartilage repair tissue. 30 Aug 2009
• Identification of integrins alpha6 and beta7 as c-Jun- and transformation-relevant genes in highly invasive fibrosarcoma cells. 30 Aug 2009
• The heparan sulfate proteoglycan (HSPG) glypican-3 mediates commitment of MC3T3-E1 cells toward osteogenesis. 30 Aug 2009
• Sulfasalazine blocks the release of proteoglycan and collagen from cytokine stimulated cartilage and down-regulates metalloproteinases. 16 Aug 2009
• Dermatan sulfate epimerase 1-deficient mice have reduced content and changed distribution of iduronic acids in dermatan sulfate and an altered collagen structure in skin. 15 Aug 2009
• PI3K, Rho, and ROCK play a key role in hypoxia-induced ATP release and ATP-stimulated angiogenic responses in pulmonary artery vasa vasorum endothelial cells. 12 Aug 2009
• Overcoming macrophage-mediated axonal dieback following CNS injury. 10 Aug 2009
• Fezf1 is required for penetration of the basal lamina by olfactory axons to promote olfactory development. 8 Aug 2009
• A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion. 2 Aug 2009
• Zonal responsiveness of the human intervertebral disc to bone morphogenetic protein-2. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Proteoglycans'

Definition: Glycoproteins which have a very high polysaccharide content.

Registry Number: 0

Descriptor UI: D011509

Alternative terms: Proteoglycans; Proteoglycan; Proteoglycan Type H;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D09.698.735; D12.776.395.650;

Online Note: search MUCOPOLYSACCHARIDES 1973-74

History Note: 77(75); was see under MUCOPOLYSACCHARIDES 1975-76

Technical Notes: polysaccharides