Proto-Oncogene Proteins c-myc
Research News and Information

Saturday, March 20, 2010

Prostaglandin E(2) promotes cell proliferation via protein kinase C/extracellular signal regulated kinase pathway-dependent induction of c-Myc expression in human esophageal squamous cell carcinoma cells.

29 Nov 2009 Overexpression of cyclooxygenase-2 (COX-2) and elevation of its derivative prostaglandin E(2) (PGE(2)) are implicated in human esophageal squamous cell carcinoma. The expression of c-Myc, an oncogenic transcription factor, is also upregulated in ... Read more...

Have you seen...?: Micro-managing and restraining pluripotent stem cells by MYC.

19 Oct 2009 The MYC proto-oncogene, which encodes a master transcriptional regulator c-Myc (herein termed Myc), has a key role in stem cell (SC) pluripotency and tumourigenesis. Its deregulated expression contributes to cancer development and enhances the ... Read more...

Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate.

4 Oct 2009 Despite clear epidemiological and genetic evidence for X-linked prostate cancer risk, all prostate cancer genes identified are autosomal. Here, we report somatic inactivating mutations and deletion of the X-linked FOXP3 gene residing at Xp11.23 in ... Read more...

Latest indexed articles for 'Proto-Oncogene Proteins c-myc'

These are the very latest articles for this heading:

• Prostaglandin E(2) promotes cell proliferation via protein kinase C/extracellular signal regulated kinase pathway-dependent induction of c-Myc expression in human esophageal squamous cell carcinoma cells. 29 Nov 2009
• Have you seen...?: Micro-managing and restraining pluripotent stem cells by MYC. 19 Oct 2009
• Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate. 4 Oct 2009
• Colocalization of somatic and meiotic double strand breaks near the Myc oncogene on mouse chromosome 15. 29 Sep 2009
• An essential role of the HIF-1alpha-c-Myc axis in malignant progression. 29 Sep 2009
• Overexpression of the far upstream element binding protein 1 in hepatocellular carcinoma is required for tumor growth. 29 Sep 2009
• Inhibition of mammalian target of rapamycin signaling potentiates the effects of all-trans retinoic acid to induce growth arrest and differentiation of human acute myelogenous leukemia cells. 29 Sep 2009
• Prion protein ablation increases cellular aggregation and embolization contributing to mechanisms of metastasis. 29 Sep 2009
• Posttranslational regulation of Myc by promyelocytic leukemia zinc finger protein. 29 Sep 2009
• On the road to iPS cell cardiovascular applications. 23 Sep 2009
• TGF-beta enforces senescence in Myc-transformed hematopoietic tumor cells through induction of Mad1 and repression of Myc activity. 15 Sep 2009
• miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. 9 Sep 2009
• Myc-regulated microRNAs attenuate embryonic stem cell differentiation. 8 Sep 2009
• cMyc increases cell number through uncoupling of cell division from cell size in CHO cells. 5 Sep 2009
• Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase. 30 Aug 2009
• MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy. 22 Aug 2009
• ApoG2 induces cell cycle arrest of nasopharyngeal carcinoma cells by suppressing the c-Myc signaling pathway. 21 Aug 2009
• iPS programmed without c-MYC yield proficient cardiogenesis for functional heart chimerism. 18 Aug 2009
• MiR-17-92 cluster is associated with 13q gain and c-myc expression during colorectal adenoma to adenocarcinoma progression. 16 Aug 2009
• The PTEN regulator DJ-1 is associated with hTERT expression in clear cell renal cell carcinoma. 13 Aug 2009

See a longer list of these articles.

Technical information about 'Proto-Oncogene Proteins c-myc'

Definition: Cellular DNA-binding proteins encoded by the c-myc genes. They are normally involved in nucleic acid metabolism and in mediating the cellular response to growth factors. Elevated and deregulated (constitutive) expression of c-myc proteins can cause tumorigenesis.

Registry Number: 0

Descriptor UI: D016271

Alternative terms: Proto-Oncogene Proteins c-myc; Proto Oncogene Proteins c myc; myc Proto-Oncogene Product p62; myc Proto Oncogene Product p62; myc Proto-Oncogene Proteins; Proto-Oncogene Proteins, myc; myc Proto Oncogene Proteins; p62(c-myc); Proto-Oncogene Products c-myc; Proto Oncogene Products c myc; Proto-Oncogene Proteins myc; Proteins myc, Proto-Oncogene; Proto Oncogene Proteins myc; myc, Proto-Oncogene Proteins; c-myc Proteins; c myc Proteins; p62 c-myc; p62 c myc; N-myc Proteins; N myc Proteins; L-myc Proteins; L myc Proteins;

Allowable Qualifiers: antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists; administration & dosage; adverse effects; analysis;

Tree Number: D12.776.260.676; D12.776.624.664.700.189; D12.776.660.765;

History Note: 91

Technical Notes: /drug eff /ultrastruct permitted; DF: note short X refs