Pyridines - Pharmacology
Research News and Information

Monday, November 23, 2009

p38 MAPK mediated in compressive stress-induced chondrogenesis of rat bone marrow MSCs in 3D alginate scaffolds.

29 Nov 2009 Mesenchymal stem cells (MSCs) are well known to have the capability to form bone and cartilage, and chondrogenesis derived from MSCs is reported to be affected by mechanical stimuli. This research was aimed to study the effects of cyclic compressive ... Read more...

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease.

21 Oct 2009 The LRRK2 (leucine-rich repeat protein kinase-2) is mutated in a significant number of Parkinson's disease patients, but little is known about its regulation and function. A common mutation changing Gly2019 to serine enhances catalytic activity, ... Read more...

Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing.

19 Oct 2009 Peripheral tissue injury is associated with changes in protein expression in sensory neurons that may contribute to abnormal nociceptive processing. We used cultured dorsal root ganglion (DRG) neurons as a model of axotomized neurons to investigate ... Read more...

Latest indexed articles for 'Pyridines - Pharmacology'

These are the very latest articles for this heading:

• p38 MAPK mediated in compressive stress-induced chondrogenesis of rat bone marrow MSCs in 3D alginate scaffolds. 29 Nov 2009
• Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. 21 Oct 2009
• Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing. 19 Oct 2009
• Kv7/KCNQ channels control action potential phasing of pyramidal neurons during hippocampal gamma oscillations in vitro. 19 Oct 2009
• Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors. 6 Oct 2009
• Discovery of novel protease activated receptors 1 antagonists with potent antithrombotic activity in vivo. 6 Oct 2009
• Proteomic and genetic approaches identify Syk as an AML target. 4 Oct 2009
• Can treating the SYK cell cure leukemia? 4 Oct 2009
• Comparative screening of glial cell types reveals extracellular matrix that inhibits retinal axon growth in a chondroitinase ABC-resistant fashion. 29 Sep 2009
• Local wound p38 MAPK inhibition attenuates burn-induced cardiac dysfunction. 29 Sep 2009
• Down-regulation of HLA Class I and NKG2D ligands through a concerted action of MAPK and DNA methyltransferases in colorectal cancer cells. 29 Sep 2009
• Prevention of Clostridium sordellii lethal toxin-induced apoptotic cell death by tauroursodeoxycholic acid. 27 Sep 2009
• Angiotensin II effects on ischemic focal ventricular tachycardia are predominantly mediated through myocardial AT(2) receptor. 23 Sep 2009
• Serotonin 1B receptor stimulation reduces D1 receptor agonist-induced dyskinesia. 21 Sep 2009
• Antidepressant actions of histone deacetylase inhibitors. 14 Sep 2009
• Serotonin targets inhibitory synapses to induce modulation of network functions. 10 Sep 2009
• Discovery of orally active 3-pyridinyl-tropane as a potent nociceptin receptor agonist for the management of cough. 8 Sep 2009
• Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors. 8 Sep 2009
• Cholinergic agonists regulate JAK2/STAT3 signaling to suppress endothelial cell activation. 7 Sep 2009
• Inbred mouse strains differ in multiple hippocampal activity traits. 2 Sep 2009

See a longer list of these articles.

Technical information about 'Pyridines'

Definition: Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.

Registry Number: 0

Descriptor UI: D011725

Alternative terms: Pyridines;

Related Mesh Headings: Piperidines;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.383.725;

Technical Notes: pyridine nucleotides will probably be NAD or NADP