Pyridines
Research News and Information

Saturday, November 21, 2009

Alveolar rhabdomyosarcoma of the extremity and nodal metastasis: Is the in-transit lymphatic system at risk?

13 Dec 2009 Alveolar rhabdomyosarcoma (RMS) of the extremity is not infrequently associated with regional node metastasis. Knowledge of lymphatic drainage of extremity RMSs is important to determine radiotherapy fields. In this report we describe two patients ... Read more...

p38 MAPK mediated in compressive stress-induced chondrogenesis of rat bone marrow MSCs in 3D alginate scaffolds.

29 Nov 2009 Mesenchymal stem cells (MSCs) are well known to have the capability to form bone and cartilage, and chondrogenesis derived from MSCs is reported to be affected by mechanical stimuli. This research was aimed to study the effects of cyclic compressive ... Read more...

Continuous and intermittent dosing of lonafarnib potentiates the therapeutic efficacy of docetaxel on preclinical human prostate cancer models.

29 Nov 2009 Lonafarnib is a potent, selective farnesyltransferase inhibitor (FTI) undergoing clinical studies for the treatment of solid tumors and hematological malignancies. Preclinically, a number of FTIs, including lonafarnib, interact with taxanes to ... Read more...

Latest indexed articles for 'Pyridines'

These are the very latest articles for this heading:

• Alveolar rhabdomyosarcoma of the extremity and nodal metastasis: Is the in-transit lymphatic system at risk? 13 Dec 2009
• p38 MAPK mediated in compressive stress-induced chondrogenesis of rat bone marrow MSCs in 3D alginate scaffolds. 29 Nov 2009
• Continuous and intermittent dosing of lonafarnib potentiates the therapeutic efficacy of docetaxel on preclinical human prostate cancer models. 29 Nov 2009
• Exposure to the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers from 3 populations with different risks of lung cancer. 13 Nov 2009
• Tenofovir coadministration is not associated with lower unboosted atazanavir plasma exposure in the clinical setting. 30 Oct 2009
• Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. 21 Oct 2009
• Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing. 19 Oct 2009
• Kv7/KCNQ channels control action potential phasing of pyramidal neurons during hippocampal gamma oscillations in vitro. 19 Oct 2009
• Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors. 6 Oct 2009
• Discovery of novel protease activated receptors 1 antagonists with potent antithrombotic activity in vivo. 6 Oct 2009
• Proteomic and genetic approaches identify Syk as an AML target. 4 Oct 2009
• Can treating the SYK cell cure leukemia? 4 Oct 2009
• Sorafenib reveals efficacy in sequential treatment of metastatic renal cell cancer. 29 Sep 2009
• Stroke incidentally identified using improved positron emission tomography for microglial activation. 29 Sep 2009
• Comparative screening of glial cell types reveals extracellular matrix that inhibits retinal axon growth in a chondroitinase ABC-resistant fashion. 29 Sep 2009
• Zolpidem dependence in a geriatric patient: a case report. 29 Sep 2009
• [Hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC): evaluation, prevention and policies to avoid occupational exposure for operating room personnel] 29 Sep 2009
• Local wound p38 MAPK inhibition attenuates burn-induced cardiac dysfunction. 29 Sep 2009
• Diffusion-weighted MRI of advanced hepatocellular carcinoma during sorafenib treatment: initial results. 29 Sep 2009
• Down-regulation of HLA Class I and NKG2D ligands through a concerted action of MAPK and DNA methyltransferases in colorectal cancer cells. 29 Sep 2009

See a longer list of these articles.

Technical information about 'Pyridines'

Definition: Compounds with a six membered aromatic ring containing NITROGEN. The saturated version is PIPERIDINES.

Registry Number: 0

Descriptor UI: D011725

Alternative terms: Pyridines;

Related Mesh Headings: Piperidines;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.383.725;

Technical Notes: pyridine nucleotides will probably be NAD or NADP