Pyridoxine
Research News and Information

Sunday, November 22, 2009

Pyridoxine inhibits depolarization-evoked glutamate release in nerve terminals from rat cerebral cortex: a possible neuroprotective mechanism?

21 Jul 2009 Pyridoxine (vitamin B(6)) protects neurons against neurotoxicity. An excessive release of glutamate is widely considered to be one of the molecular mechanisms of neuronal damage in several neurological diseases. We investigated whether pyridoxine ... Read more...

Metadoxine, an ion-pair of pyridoxine and L-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway.

12 Jul 2009 Adipogenesis is orchestrated by the expression of master adipogenic regulators. In particular, phosphorylation of cAMP response element binding protein (CREB) by protein kinase A promotes CREB nuclear translocation, thereby inducing expression of ... Read more...

Pyridoxine-dependent seizures: 10-year follow-up of eight cases.

29 Jun 2009 Eight children with pyridoxine-dependent seizures (PDS) were seen over a period of 10 years. Of those children, 6 are on regular follow-up. Four of the children were seen in one family. All the patients presented with refractory seizures, mainly ... Read more...

Latest indexed articles for 'Pyridoxine'

These are the very latest articles for this heading:

• Development of a pharmacist-managed latent tuberculosis clinic. 30 Aug 2009
• Pyridoxine in pregnant women receiving antituberculous drugs. 30 Jul 2009
• Pyridoxine inhibits depolarization-evoked glutamate release in nerve terminals from rat cerebral cortex: a possible neuroprotective mechanism? 21 Jul 2009
• Metadoxine, an ion-pair of pyridoxine and L-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway. 12 Jul 2009
• Pyridoxine-dependent seizures: 10-year follow-up of eight cases. 29 Jun 2009
• Vincristine induced unilateral ptosis. 30 May 2009
• Vitamins in the monkey brain: An immunocytochemical study. 25 May 2009
• Simultaneous determination of chondroitin sulfate sodium, allantoin and pyridoxine hydrochloride in pharmaceutical eye drops by an ion-pair high-performance liquid chromatography. 7 May 2009
• Folinic acid-responsive seizures are identical to pyridoxine-dependent epilepsy. 29 Apr 2009
• Vascular care in patients with Alzheimer's disease with cerebrovascular lesions-a randomized clinical trial. 29 Apr 2009
• Long-term neurodevelopment of children exposed to maternal nausea and vomiting of pregnancy and diclectin. 22 Apr 2009
• [Effects of excess pyridoxine-HCl on growth and urinary excretion of water-soluble vitamins in weaning rats] 30 Mar 2009
• Behavioral effects of levetiracetam mitigated by pyridoxine. 30 Mar 2009
• Two novel ALDH7A1 (antiquitin) splicing mutations associated with pyridoxine-dependent seizures. 30 Mar 2009
• High-dosage pyridoxine-induced auditory neuropathy and protection with coffee in mice. 30 Mar 2009
• Pyridoxine-dependent epilepsy: normal outcome in a patient with late diagnosis after prolonged status epilepticus causing cortical blindness. 15 Mar 2009
• Epileptic status refractory to conventional treatment caused by vitamin B6 deficiency. 27 Feb 2009
• New treatment paradigms in neonatal metabolic epilepsies. 22 Feb 2009
• Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women's Antioxidant and Folic Acid Cardiovascular Study. 21 Feb 2009
• The primary hyperoxalurias. 16 Feb 2009

See a longer list of these articles.

Technical information about 'Pyridoxine'

Definition: The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).

Chemical name: 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-

Registry Number: 65-23-6

Descriptor UI: D011736

Alternative terms: Pyridoxine; Pyridoxol; Pyridoxin; Rodex; Pyridoxine Hydrochloride; Pyridoxol Hydrochloride;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Vitamin B Complex;

Tree Number: D03.383.725.676.925.875;

Technical Notes: deficiency: coordinate PYRIDOXINE /defic (IM) with VITAMIN B 6 DEFICIENCY (IM)