Pyrophosphatases
Research News and Information

Monday, November 23, 2009

Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression.

22 Sep 2009 Understanding the molecular mechanism(s) of how miRNAs repress mRNA translation is a fundamental challenge in RNA biology. Here we use a validated cell-free system from Drosophila embryos to investigate how miR2 inhibits translation initiation. By ... Read more...

Diphosphonucleotide phosphatase/phosphodiesterase (PPD1) from yellow lupin (Lupinus luteus L.) contains an iron-manganese center.

11 Sep 2009 Yellow lupin diphosphonucleotide phosphatase/phosphodiesterase (PPD1) represents a novel group of enzymes. Here we report that it possesses one iron atom and one manganese atom (1:1 molar ratio) per subunit. The enzyme exhibits visible absorption ... Read more...

Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells.

30 Aug 2009 Increased expression of autotaxin in tumors including glioblastoma, breast, renal, ovarian, lung, and thyroid cancers is associated with increased tumor aggressiveness. Autotaxin promotes metastasis as well as cell growth, survival, and migration of ... Read more...

Latest indexed articles for 'Pyrophosphatases'

These are the very latest articles for this heading:

• Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression. 22 Sep 2009
• Diphosphonucleotide phosphatase/phosphodiesterase (PPD1) from yellow lupin (Lupinus luteus L.) contains an iron-manganese center. 11 Sep 2009
• Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells. 30 Aug 2009
• The African swine fever virus g5R protein possesses mRNA decapping activity. 17 Aug 2009
• Concerted bifunctionality of the dCTP deaminase-dUTPase from Methanocaldococcus jannaschii: a structural and pre-steady state kinetic analysis. 12 Aug 2009
• ENPP1 Q121 variant, increased pulse pressure and reduced insulin signaling, and nitric oxide synthase activity in endothelial cells. 11 Aug 2009
• The basophil activation test in immediate-type drug allergy. 30 Jul 2009
• Expression of autotaxin, an ectoenzyme that produces lysophosphatidic acid, in human placenta. 30 Jul 2009
• Magic spot: (p) ppGpp. 30 Jul 2009
• Overproduction of geranylgeraniol by metabolically engineered Saccharomyces cerevisiae. 8 Jul 2009
• The flexible motif V of Epstein-Barr virus deoxyuridine 5'-triphosphate pyrophosphatase is essential for catalysis. 5 Jul 2009
• Kinetic, dynamic, ligand binding properties, and structural models of a dual-substrate specific nudix hydrolase from Schizosaccharomyces pombe. 5 Jul 2009
• Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo. Jul 2009
• The cartilage intermediate layer protein gene is associated with lumbar disc degeneration in collegiate judokas. 28 Jun 2009
• NTPDases in the neuroendocrine hypothalamus: possible energy regulators of the positive gonadotrophin feedback. 14 Jun 2009
• Fetal hydrops, hyperechogenic arteries and pathological doppler findings at 29 weeks: prenatal presentation of generalized arterial calcification of infancy - a novel mutation in ENPP1. 8 Jun 2009
• Energetics of MazG unfolding in correlation with its structural features. 8 Jun 2009
• Autotaxin. 7 Jun 2009
• Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo. 7 Jun 2009
• Mammary tumorigenesis through LPA receptor signaling. 31 May 2009

See a longer list of these articles.

Technical information about 'Pyrophosphatases'

Definition: A group of enzymes within the class EC 3.6.1.- that catalyze the hydrolysis of diphosphate bonds, chiefly in nucleoside di- and triphosphates. They may liberate either a mono- or diphosphate. EC 3.6.1.-.

Registry Number: EC 3.6.1.-

Descriptor UI: D011755

Alternative terms: Pyrophosphatases;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.277.040.600;

Online Note: use PYROPHOSPHATASES to search PYROPHOSPHATASE 1966-72

History Note: 73; was PYROPHOSPHATASE 1963-72