Pyrroles - Pharmacology
Research News and Information

Monday, November 23, 2009

Development and maturation of invariant NKT cells in the presence of lysosomal engulfment.

29 Sep 2009 A defect in invariant NKT (iNKT) cell selection was hypothesized in lysosomal storage disorders (LSD). Accumulation of glycosphingolipids (GSL) in LSD could influence lipid loading and/or presentation causing entrapment of endogenous ligand(s) ... Read more...

Inhibition of transforming growth factor beta receptor I kinase blocks hepatocellular carcinoma growth through neo-angiogenesis regulation.

29 Sep 2009 Curative therapies for patients with hepatocellular carcinoma (HCC) are mainly invasive, and with the exception of sorafenib, no medical treatments are available for advanced or metastatic stages of HCC. We investigated the antitumoral effect of ... Read more...

Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways.

26 Sep 2009 Chronic inflammatory airway diseases including asthma are characterized by immune dysfunction to inhaled allergens. Our previous studies demonstrated that T cell priming to inhaled allergens requires LPS, which is ubiquitously present in household ... Read more...

Latest indexed articles for 'Pyrroles - Pharmacology'

These are the very latest articles for this heading:

• Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065. 6 Oct 2009
• Development and maturation of invariant NKT cells in the presence of lysosomal engulfment. 29 Sep 2009
• Inhibition of transforming growth factor beta receptor I kinase blocks hepatocellular carcinoma growth through neo-angiogenesis regulation. 29 Sep 2009
• Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways. 26 Sep 2009
• Thymic stromal lymphopoietin induction by polyinosinic:polycytidylic acid in human keratinocytes is preferentially mediated through protein kinase R and retinoid-inducible gene I and not Toll-like receptor 3. 17 Sep 2009
• MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer. 13 Sep 2009
• Activation of adenylate cyclase by forskolin increases the protein stability of RCAN1 (DSCR1 or Adapt78). 11 Sep 2009
• Human melanoma cells under endoplasmic reticulum stress are more susceptible to apoptosis induced by the BH3 mimetic obatoclax. 30 Aug 2009
• Dynamic contrast-enhanced magnetic resonance imaging of vascular changes induced by sunitinib in papillary renal cell carcinoma xenograft tumors. 30 Aug 2009
• Atorvastatin induces thrombomodulin expression in the aorta of cholesterol-fed rabbits and in TNFalpha-treated human aortic endothelial cells. 30 Aug 2009
• Coagulation factor Xa activates thrombin in ischemic neural tissue. 29 Aug 2009
• Expression of neuropeptide hormone receptors in human adrenal tumors and cell lines: antiproliferative effects of peptide analogues. 25 Aug 2009
• Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo. 24 Aug 2009
• Atorvastatin ameliorates tubulointerstitial fibrosis and protects renal function in chronic partial ureteral obstruction cases. 16 Aug 2009
• Arterial destiffening with atorvastatin in overweight and obese middle-aged and older adults. 15 Aug 2009
• Developmentally spliced PKCbetaII provides a possible link between mTORC2 and Akt kinase to regulate 3T3-L1 adipocyte insulin-stimulated glucose transport. 13 Aug 2009
• Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX). 11 Aug 2009
• Amide isosteres of oroidin: assessment of antibiofilm activity and C. elegans toxicity. 11 Aug 2009
• Design of a new histamine H3 receptor antagonist chemotype: (3aR,6aR)-5-alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, synthesis, and structure-activity relationships. 11 Aug 2009
• Inhibition of epithelial to mesenchymal transition in metastatic prostate cancer cells by the novel proteasome inhibitor, NPI-0052: pivotal roles of Snail repression and RKIP induction. 25 Jul 2009

See a longer list of these articles.

Technical information about 'Pyrroles'

Definition: Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.

Chemical name: 1-aza-2,4-cyclopentadiene

Registry Number: 0

Descriptor UI: D011758

Alternative terms: Pyrroles;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.383.129.578;