Pyruvic Acid - Pharmacology
Research News and Information

Sunday, November 22, 2009

Effect of pyruvate, lactate and insulin on ATP supply and demand in unpaced perfused rat heart.

10 Oct 2009 Mitochondrial respiration/oxidative phosphorylation is the main source of energy, in the form of ATP, in the heart under physiological conditions. Different respiratory substrates were used in various experiments during heart perfusion: glucose, ... Read more...

Pyruvate-fortified cardioplegia evokes myocardial erythropoietin signaling in swine undergoing cardiopulmonary bypass.

16 Sep 2009 Pyruvate-fortified cardioplegia protects myocardium and hastens postsurgical recovery of patients undergoing cardiopulmonary bypass (CPB). Pyruvate reportedly suppresses degradation of the alpha-subunit of hypoxia-inducible factor-1 (HIF-1), an ... Read more...

Differentiation effect of pyruvate and uridine on cultured U937-rho degrees cells.

29 Jun 2009 The human pro-monocytic leukemia U937 cell line was previously reported to become rho degrees cells after a long-term ethidium bromide exposure. In the authors' extensive PCR studies with different pairs of primers for the mtDNA molecule they showed ... Read more...

Latest indexed articles for 'Pyruvic Acid - Pharmacology'

These are the very latest articles for this heading:

• Effect of pyruvate, lactate and insulin on ATP supply and demand in unpaced perfused rat heart. 10 Oct 2009
• Pyruvate-fortified cardioplegia evokes myocardial erythropoietin signaling in swine undergoing cardiopulmonary bypass. 16 Sep 2009
• Differentiation effect of pyruvate and uridine on cultured U937-rho degrees cells. 29 Jun 2009
• Pyruvate prevents aging of mouse oocytes. 20 May 2009
• Strombine dehydrogenase in the demosponge Suberites domuncula: characterization and kinetic properties of the enzyme crucial for anaerobic metabolism. 16 May 2009
• PPARgamma stimulation promotes mitochondrial biogenesis and prevents glucose deprivation-induced neuronal cell loss. 11 May 2009
• Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets. 15 Apr 2009
• The neuromediator glutamate, through specific substrate interactions, enhances mitochondrial ATP production and reactive oxygen species generation in nonsynaptic brain mitochondria. 18 Mar 2009
• Production of panic-like symptoms by lactate is associated with increased neural firing and oxidation of brain redox in the rat hippocampus. 21 Feb 2009
• Choice of DMEM, formulated with or without pyruvate, plays an important role in assessing the in vitro cytotoxicity of oxidants and prooxidant nutraceuticals. 28 Jan 2009
• Functional properties of the Ustilago maydis alternative oxidase under oxidative stress conditions. 15 Jan 2009
• Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells. 7 Dec 2008
• Antimicrobial action of N-(n-dodecyl)diethanolamine on Escherichia coli: effects on enzymes and growing cultures. 29 Nov 2008
• Inhaled sodium pyruvate improved FEV1 and decreased expired breath levels of nitric oxide in patients with chronic obstructive pulmonary disease. 29 Nov 2008
• Mitochondrial remodeling in differentiating neuroblasts. 17 Nov 2008
• [Transamination in the mechanism of protection of mitochondria from Ca2+ overload] 30 Oct 2008
• Intravenous sodium pyruvate protects against cerulein-induced acute pancreatitis. 30 Jul 2008
• Effect of glucose and pyruvate on nuclear and cytoplasmic maturation of porcine oocytes in a chemically defined medium. 24 Jul 2008
• Formate acts as a diffusible signal to induce Salmonella invasion. 16 Apr 2008
• Mitochondrial free radical production induced by glucose deprivation in cerebellar granule neurons. 30 Jan 2008

See a longer list of these articles.

Technical information about 'Pyruvic Acid'

Definition: An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)

Registry Number: 127-17-3

Descriptor UI: D019289

Alternative terms: Pyruvic Acid; Acid, Pyruvic; Pyruvate;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.241.607.812.800;

Online Note: use PYRUVIC ACID (NM) to search PYRUVIC ACID 1981-96

History Note: 97; was PYRUVIC ACID (NM) 1981-96

Technical Notes: do not confuse X ref PYRUVATE with PYRUVATES