Raclopride - Pharmacology
Research News and Information

Sunday, November 22, 2009

Differential effects of topiramate on prefrontal glutamatergic transmission when combined with raclopride or clozapine.

29 Sep 2009 Treatment with topiramate may improve negative symptoms in schizophrenia when added to typical antipsychotic drugs (APDs) but not to clozapine. Both dopaminergic and glutamatergic transmissions in the medial prefrontal cortex (mPFC) are facilitated ... Read more...

Acute neurobehavioral effects of toluene: involvement of dopamine and NMDA receptors.

14 Sep 2009 Toluene, a widely used and commonly abused organic solvent, causes a variety of behavioral disturbances in both humans and animals. In this study, the effects of toluene on locomotor activity, motor coordination, and passive avoidance learning, ... Read more...

Pharmacological characterization of harmaline-induced tremor activity in mice.

31 May 2009 Harmaline-induced tremor in rodents is a model of essential tremor. We utilized a novel assay to quantify tremor activity in mice and found that tremor activity was dependent on harmaline dose. The first-line clinical essential tremor treatments ... Read more...

Latest indexed articles for 'Raclopride - Pharmacology'

These are the very latest articles for this heading:

• Differential effects of topiramate on prefrontal glutamatergic transmission when combined with raclopride or clozapine. 29 Sep 2009
• Acute neurobehavioral effects of toluene: involvement of dopamine and NMDA receptors. 14 Sep 2009
• Pharmacological characterization of harmaline-induced tremor activity in mice. 31 May 2009
• Cue-induced dopamine release predicts cocaine preference: positron emission tomography studies in freely moving rodents. 11 May 2009
• Dopamine D(2/3) receptor occupancy of apomorphine in the nonhuman primate brain--a comparative PET study with [11C]raclopride and [11C]MNPA. 29 Apr 2009
• High fat diet and food restriction differentially modify the behavioral effects of quinpirole and raclopride in rats. 23 Mar 2009
• Antipsychotics affect multiple calcium calmodulin dependent proteins. 11 Mar 2009
• Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanisms. 27 Feb 2009
• Dopamine D2High receptors measured ex vivo are elevated in amphetamine-sensitized animals. 27 Feb 2009
• Baclofen, raclopride, and naltrexone differentially affect intake of fat/sucrose mixtures under limited access conditions. 11 Feb 2009
• Assessment of bursting activity and interspike intervals variability: a case study for methodological comparison. 31 Jan 2009
• Dopaminergic modulation of motor maps in rat motor cortex: an in vivo study. 4 Jan 2009
• Selective serotonin reuptake inhibitor (SSRI) modulation of striatal dopamine measured with [11C]-raclopride and positron emission tomography. 30 Dec 2008
• Genetic variance contributes to dopamine receptor antagonist-induced inhibition of sucrose intake in inbred and outbred mouse strains. 23 Dec 2008
• Motor sequence learning in primate: role of the D2 receptor in movement chunking during consolidation. 9 Nov 2008
• Dopamine D2/D3 receptor agonist quinpirole impairs spatial reversal learning in rats: investigation of D3 receptor involvement in persistent behavior. Oct 2008
• Abstinence from chronic cocaine self-administration alters striatal dopamine systems in rhesus monkeys. Sep 2008
• Differential involvement of dopamine D1 receptors in morphine- and lithium-conditioned saccharin avoidance. 26 Aug 2008
• Preferential enhancement of dopamine transmission within the nucleus accumbens shell by cocaine is attributable to a direct increase in phasic dopamine release events. 25 Aug 2008
• Dopaminergic D1 and D2 receptors are essential for the arousal effect of modafinil. 18 Aug 2008

See a longer list of these articles.

Technical information about 'Raclopride'

Definition: A substituted benzamide that has antipsychotic properties. It is a dopamine D2 receptor (see RECEPTORS, DOPAMINE D2) antagonist.

Chemical name: Benzamide, 3,5-dichloro-N-((1-ethyl-2-pyrrolidinyl)-methyl)-2-hydroxy-6-methoxy-

Registry Number: 84225-95-6

Descriptor UI: D020891

Alternative terms: Raclopride; FLB-472; FLB 472; FLB472; Raclopride C11; C11, Raclopride; FLA-870; FLA 870; FLA870;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Antipsychotic Agents; Dopamine Antagonists;

Tree Number: D02.065.277.761; D02.241.223.100.120.761;

History Note: 2000; use RACLOPRIDE 1985-1999