Rats, Inbred SHR
Research News and Information

Sunday, November 22, 2009

Loss of arterial and renal nitric oxide bioavailability in hypertensive rats with diabetes: effect of beta-blockers.

Sep 2009 BACKGROUND: Endothelial cell (EC) dysfunction contributes to hypertension and mechanisms of atherosclerosis. Agents that improve EC function may provide vascular protection, especially in patients with multiple risk factors. In this study, we ... Read more...

Dexamethasone decreases neuronal nitric oxide release in mesenteric arteries from hypertensive rats through decreased protein kinase C activation.

22 Aug 2009 Neuronal NO plays a functional role in many vascular tissues, including MAs (mesenteric arteries). Glucocorticoids alter NO release from endothelium and the CNS (central nervous system), but no results from peripheral innervation have been reported. ... Read more...

Exaggerated blood pressure variability superimposed on hypertension aggravates cardiac remodeling in rats via angiotensin II system-mediated chronic inflammation.

22 Aug 2009 Hypertensive patients with large blood pressure variability (BPV) have aggravated end-organ damage. However, the pathogenesis remains unknown. We investigated whether exaggerated BPV aggravates hypertensive cardiac remodeling and function by ... Read more...

Latest indexed articles for 'Rats, Inbred SHR'

These are the very latest articles for this heading:

• Loss of arterial and renal nitric oxide bioavailability in hypertensive rats with diabetes: effect of beta-blockers. Sep 2009
• Dexamethasone decreases neuronal nitric oxide release in mesenteric arteries from hypertensive rats through decreased protein kinase C activation. 22 Aug 2009
• Exaggerated blood pressure variability superimposed on hypertension aggravates cardiac remodeling in rats via angiotensin II system-mediated chronic inflammation. 22 Aug 2009
• Left ventricular remodeling with exercise in hypertension. 5 Aug 2009
• Effect of melatonin, captopril, spironolactone and simvastatin on blood pressure and left ventricular remodelling in spontaneously hypertensive rats. 30 Jul 2009
• Comparison of the effects of indapamide and captopril on the development of spontaneous hypertension. 30 Jul 2009
• Endothelial dysfunction in spontaneously hypertensive rats: focus on methodological aspects. 30 Jul 2009
• Melatonin prevents fibrosis but not hypertrophy development in the left ventricle of NG-nitro-L-arginine-methyl ester hypertensive rats. 30 Jul 2009
• Recent trends in hypertension treatment: perspectives from animal studies. 30 Jul 2009
• Renal and vascular glutathione S-transferase mu is not affected by pharmacological intervention to reduce systolic blood pressure. 30 Jul 2009
• Upregulation of intermediate calcium-activated potassium channels counterbalance the impaired endothelium-dependent vasodilation in stroke-prone spontaneously hypertensive rats. 29 Jul 2009
• Klotho gene delivery prevents the progression of spontaneous hypertension and renal damage. 25 Jul 2009
• Antihypertensive effect of a polyphenol-rich cocoa powder industrially processed to preserve the original flavonoids of the cocoa beans. 20 Jul 2009
• Dissection of chromosome 18 blood pressure and salt-sensitivity quantitative trait loci in the spontaneously hypertensive rat. 18 Jul 2009
• The effect of recombinant aminopeptidase A (APA) on hypertension in pregnant spontaneously hypertensive rats (SHRs). 14 Jul 2009
• Neither in vivo MRI nor behavioural assessment indicate therapeutic efficacy for a novel 5HT(1A) agonist in rat models of ischaemic stroke. 14 Jul 2009
• Combination therapy with normobaric oxygen (NBO) plus thrombolysis in experimental ischemic stroke. 13 Jul 2009
• Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor. 11 Jul 2009
• AT(1) receptor blockers increase insulin-like growth factor-I production by stimulating sensory neurons in spontaneously hypertensive rats. 5 Jul 2009
• Tumor necrosis factor-alpha-converting enzyme is a key regulator of agonist-induced cardiac hypertrophy and fibrosis. 4 Jul 2009

See a longer list of these articles.

Technical information about 'Rats, Inbred SHR'

Definition: A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke.

Descriptor UI: D011918

Alternative terms: Rats, Inbred SHR; Inbred SHR Rat; Inbred SHR Rats; Rat, Inbred SHR; SHR Rat, Inbred; SHR Rats, Inbred; Rats, SHR; Rat, SHR; SHR Rat; SHR Rats; Rats, Spontaneously Hypertensive; Rat, Spontaneously Hypertensive; Spontaneously Hypertensive Rat; Spontaneously Hypertensive Rats;

Allowable Qualifiers: abnormalities; anatomy & histology; blood; cerebrospinal fluid; classification; embryology; genetics; growth & development; immunology; injuries; metabolism; microbiology; parasitology; physiology; psychology; surgery; urine; virology;

Tree Number: B01.050.157.760.300; B01.050.199.520.760.300; B01.150.900.649.865.635.505.700.400.300;

History Note: 91(85); was see under RATS, INBRED STRAINS 1985-90

Technical Notes: NIM when exper animal: no qualif; when IM, qualif permitted; do not forget also to check tag RATS