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Receptor Activator of Nuclear Factor-kappa B - Metabolism
Research News and Information
Definition of 'Receptor Activator of Nuclear Factor-kappa B'A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It also expressed on DENDRITIC CELLS where is plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS. Common names: Receptor Activator of Nuclear Factor-kappa B; Receptor Activator of Nuclear Factor kappa B; TRANCE Receptor; TRANCE-R; TRANCE R; Tumor Necrosis Factor Receptor Superfamily, Member 11a; NF-KappaB Receptor Activator; Activator, NF-KappaB Receptor; NF KappaB Receptor Activator |
Monday, November 23, 2009
Osteoporosis associated with neutralizing autoantibodies against osteoprotegerin.
6 Oct 2009 
Autoantibodies against osteoprotegerin, which block the inhibitory effect of osteoprotegerin on signaling by the receptor activator of nuclear factor (NF)-kappaB (RANK), were identified in a man with celiac disease who presented with severe ... Read more...
Bone loss in survival motor neuron (Smn(-/-) SMN2) genetic mouse model of spinal muscular atrophy.
30 Aug 2009 Spinal muscular atrophy (SMA) is characterized by degenerating lower motor neurons and an increased incidence of congenital bone fractures. Survival motor neuron (SMN) levels are significantly reduced due to deletions/mutations in the telomeric SMN1 ... Read more...
Increased RANKL expression is related to tumour migration and metastasis of renal cell carcinomas.
30 Jul 2009 Receptor activator of NF-kappaB ligand (RANKL) and its receptor, receptor activator of NF-kappaB (RANK), play a key role in osteoclastogenesis, and osteoprotegerin (OPG) acts as a decoy receptor for RANKL. We investigated the role of the ... Read more...
Latest indexed articles for 'Receptor Activator of Nuclear Factor-kappa B - Metabolism'
These are the very latest articles for this heading:
- Osteoporosis associated with neutralizing autoantibodies against osteoprotegerin. 6 Oct 2009
- Bone loss in survival motor neuron (Smn(-/-) SMN2) genetic mouse model of spinal muscular atrophy. 30 Aug 2009
- Increased RANKL expression is related to tumour migration and metastasis of renal cell carcinomas. 30 Jul 2009
- Expression of eight genes of nuclear factor-kappa B pathway in multiple myeloma using bone marrow aspirates obtained at diagnosis. 30 Jul 2009
- Regulation of dendritic cell survival and cytokine production by osteoprotegerin. 27 Jul 2009
- Non-association between polymorphisms of the frizzled receptor genes and bone mineral density in postmenopausal Korean women.
10 Jun 2009 - A theoretical model for simulating effect of parathyroid hormone on bone metabolism at cellular level. 30 May 2009
- Alumina ceramic particles, in comparison with titanium particles, hardly affect the expression of RANK-, TNF-alpha-, and OPG-mRNA in the THP-1 human monocytic cell line. 30 May 2009
- Crystallization and preliminary X-ray analysis of mouse RANK and its complex with RANKL. 20 May 2009
- [The participation of RANK, RANKL and OPG in tumor osteolysis] 13 May 2009
- RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis. 13 May 2009
- RANKL links arterial calcification with osteolysis.
6 May 2009 - The affinity of human RANK binding to its ligand RANKL. May 2009
- RANKL increases vascular smooth muscle cell calcification through a RANK-BMP4-dependent pathway. 24 Mar 2009
- New perspective in osteoarthritis: the OPG and RANKL system as a potential therapeutic target? 27 Feb 2009
- Canonical and non-canonical pathways of osteoclast formation. 27 Feb 2009
- Receptor activator of nuclear factor-kappa B ligand (RANKL) stimulates bone-associated tumors through functional RANK expressed on bone-associated cancer cells? 30 Jan 2009
- Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. 31 Dec 2008
- RANKL/RANK as key factors for osteoclast development and bone loss in arthropathies. 30 Dec 2008
- Bone loss in the spondyloarthropathies: role of osteoclast, RANKL, RANK and OPG in the spondyloarthropathies. 30 Dec 2008
See a longer list of these articles.
Technical information about 'Receptor Activator of Nuclear Factor-kappa B'
Definition: A tumor necrosis factor receptor family member that is specific for RANK LIGAND and plays a role in bone homeostasis by regulating osteoclastogenesis. It also expressed on DENDRITIC CELLS where is plays a role in regulating dendritic cell survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Registry Number: 0
Descriptor UI: D053246
Alternative terms: Receptor Activator of Nuclear Factor-kappa B; Receptor Activator of Nuclear Factor kappa B; TRANCE Receptor; TRANCE-R; TRANCE R; Tumor Necrosis Factor Receptor Superfamily, Member 11a; NF-KappaB Receptor Activator; Activator, NF-KappaB Receptor; NF KappaB Receptor Activator; Receptor Activator, NF-KappaB; Receptors, Tumor Necrosis Factor, Member 11a; TNFRSF11A Protein; RANK Protein; Receptor Activator of NF-kappa B; Receptor Activator of NF kappa B; Receptor Activator of NF-kappaB; Receptor Activator of NF kappaB; Receptor Activator of Nuclear Factor-kappaB; Receptor Activator of Nuclear Factor kappaB; NF-Kappa B Receptor Activator; NF Kappa B Receptor Activator;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;
Tree Number: D12.776.543.750.705.852.760.345;
History Note: 2007(1997)