Receptor, erbB-2 - Metabolism
Research News and Information

Sunday, November 22, 2009

Amplification and expression of EGFR and ERBB2 in Wilms tumor.

13 Oct 2009 Wilms tumor is one of the most common solid tumors in children. We evaluated expression and amplification of a number of genes and their prognostic significance in 45 patients with Wilms tumor, using tissue microarray technology. The expression of ... Read more...

Increased expression of ErbB-2 in liver is associated with hepatitis B x antigen and shorter survival in patients with liver cancer.

13 Oct 2009 Hepatitis B x antigen, or HBxAg, contributes importantly to the pathogenesis of hepatocellular carcinoma (HCC). Given that HBxAg constitutively activates beta-catenin and that upregulated ErbB-2 promotes beta-catenin signaling in other tumor types, ... Read more...

Parity and age at first childbirth in relation to the risk of different breast cancer subgroups.

13 Oct 2009 The aim of the present study was to examine parity and age at first childbirth, in relation to the risk of specific breast cancer subgroups. A prospective cohort, The Malmö Diet and Cancer Study, including 17,035 women were followed with linkage to ... Read more...

Latest indexed articles for 'Receptor, erbB-2 - Metabolism'

These are the very latest articles for this heading:

• Amplification and expression of EGFR and ERBB2 in Wilms tumor. 13 Oct 2009
• Increased expression of ErbB-2 in liver is associated with hepatitis B x antigen and shorter survival in patients with liver cancer. 13 Oct 2009
• Parity and age at first childbirth in relation to the risk of different breast cancer subgroups. 13 Oct 2009
• Should a biopsy be recommended to confirm metastatic disease in women with breast cancer? 29 Sep 2009
• EGFR and HER2 expression in advanced biliary tract cancer. 26 Sep 2009
• Human epidermal growth factor receptor 2-positive breast cancer and central nervous system metastases. 19 Sep 2009
• The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. 16 Sep 2009
• Epidermal growth factor receptor ligands as new extracellular targets for the metastasis-promoting S100A4 protein. 7 Sep 2009
• Mouse mammary tumor virus p75 and p110 CUX1 transgenic mice develop mammary tumors of various histologic types. 6 Sep 2009
• Cancer: The fat and the furious. Sep 2009
• An unusual triple-negative breast carcinoma. 30 Aug 2009
• Coordinated expression of ER, PR and HER2 define different prognostic subtypes among poorly differentiated breast carcinomas. 30 Aug 2009
• Uptake of plasmid-loaded nanoparticles in breast cancer cells and effect on Plk1 expression. 30 Aug 2009
• Pharmacotherapy of triple-negative breast cancer. 30 Aug 2009
• Tyrosine-phosphorylation of the 12th armadillo-repeat of beta-catenin is associated with cadherin dysfunction in human cancer. 30 Aug 2009
• Standardization of HER2 immunohistochemistry in breast cancer by automated quantitative analysis. 30 Aug 2009
• Prediction of local recurrence, distant metastases, and death after breast-conserving therapy in early-stage invasive breast cancer using a five-biomarker panel. 29 Aug 2009
• ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor. 28 Aug 2009
• Anthracycline war: no victor yet. 23 Aug 2009
• c-Src associates with ErbB2 through an interaction between catalytic domains and confers enhanced transforming potential. 22 Aug 2009

See a longer list of these articles.

Technical information about 'Receptor, erbB-2'

Definition: A cell surface protein-tyrosine kinase receptor that is found to be overexpressed in a significant number of adenocarcinomas. It has extensive homology to and can heterodimerize with the EGF receptor (RECEPTOR, EPIDERMAL GROWTH FACTOR), the erbB-3 receptor (RECEPTOR, ERBB-3) and the erbB-4 receptor. Activation of the erbB-2 receptor occurs during heterodimer formation with a ligand-bound erbB receptor family members.

Registry Number: EC 2.7.1.112

Descriptor UI: D018719

Alternative terms: Receptor, erbB-2; Receptor, erbB 2; erbB-2 Receptor; neu Receptor; Proto-Oncogene Protein p185(neu); Proto-Oncogene Proteins c-erbB-2; Proto Oncogene Proteins c erbB 2; p185(c-neu); Receptors, erbB-2; Receptors, erbB 2; erbB-2 Receptors; erbB-2 Proto-Oncogene Protein; Proto-Oncogene Protein, erbB-2; erbB 2 Proto Oncogene Protein; erbB-2 Receptor Protein-Tyrosine Kinase; erbB 2 Receptor Protein Tyrosine Kinase; neu Proto-Oncogene Protein; Proto-Oncogene Protein, neu; neu Proto Oncogene Protein; HER-2 Proto-Oncogene Protein; HER 2 Proto Oncogene Protein; Proto-Oncogene Protein, HER-2; Proto-Oncogene Protein HER-2; Proto Oncogene Protein HER 2; Receptor, neu; Oncogene Protein HER-2; Oncogene Protein HER 2; c-erbB-2 Protein; c erbB 2 Protein;

Related Mesh Headings: Genes, erbB-2;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D08.811.913.696.620.682.725.400.150; D12.776.543.750.060.374; D12.776.543.750.750.400.350; D12.776.624.664.700.642; D23.101.840.642;

History Note: 2000(1995); use RECEPTOR, ERBB-2 (NM) 1985-1994