Receptor, Fibroblast Growth Factor, Type 2 - Genetics
Research News and Information

Saturday, November 21, 2009

FGFR2 intronic polymorphisms interact with reproductive risk factors of breast cancer: results of a case control study in Japan.

13 Oct 2009 Recently, 2 genome-wide association studies demonstrated that single nucleotide polymorphisms (SNPs) of the fibroblast growth factor receptor 2 (FGFR2) gene at intron 2 are significantly associated with the risk of female breast cancer. As the next ... Read more...

Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice.

10 Aug 2009 FGF19 is a hormone that regulates bile acid and glucose homeostasis. Progress has been made in identifying cofactors for receptor activation. However, several functions of FGF19 have not yet been fully defined, including the actions of FGF19 on ... Read more...

Tyrosine kinase inhibition: Ligand binding and conformational change in c-Kit and c-Abl.

2 Aug 2009 The conformational flexibility exhibited by protein kinases poses an enormous challenge to the design of cancer therapeutics. Additionally the high degree of structural conservation within the kinase superfamily often leads to inhibitors that ... Read more...

Latest indexed articles for 'Receptor, Fibroblast Growth Factor, Type 2 - Genetics'

These are the very latest articles for this heading:

• FGFR2 intronic polymorphisms interact with reproductive risk factors of breast cancer: results of a case control study in Japan. 13 Oct 2009
• Selective activation of FGFR4 by an FGF19 variant does not improve glucose metabolism in ob/ob mice. 10 Aug 2009
• Tyrosine kinase inhibition: Ligand binding and conformational change in c-Kit and c-Abl. 2 Aug 2009
• Conditional gene inactivation reveals roles for Fgf10 and Fgfr2 in establishing a normal pattern of epithelial branching in the mouse lung. 30 Jul 2009
• Medical treatment of craniosynostosis: recombinant Noggin inhibits coronal suture closure in the rat craniosynostosis model. 30 Jul 2009
• Novel FGFR2 deletion in a patient with Beare-Stevenson-like syndrome. 30 Jul 2009
• Neutrophil MMP-9 proenzyme, unencumbered by TIMP-1, undergoes efficient activation in vivo and catalytically induces angiogenesis via a basic fibroblast growth factor (FGF-2)/FGFR-2 pathway. 14 Jul 2009
• The ups and downs of mutation frequencies during aging can account for the apert syndrome paternal age effect. 8 Jul 2009
• Fibroblast growth factors in development and cancer: insights from the mammary and prostate glands. 29 Jun 2009
• Phosphorylation and lipid raft association of fibroblast growth factor receptor-2 in oligodendrocytes. 29 Jun 2009
• Epithelial-specific requirement of FGFR2 signaling during tooth and palate development. 13 Jun 2009
• Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study. 4 Jun 2009
• Histone-acetylated control of fibroblast growth factor receptor 2 intron 2 polymorphisms and isoform splicing in breast cancer. 2 Jun 2009
• KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin. 25 May 2009
• The role of senescence and prosurvival signaling in controlling the oncogenic activity of FGFR2 mutants associated with cancer and birth defects. 27 Apr 2009
• FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate. 13 Apr 2009
• Hrs regulates the endocytic sorting of the fibroblast growth factor receptor 2b. 8 Apr 2009
• Getting under the skin of alternative splicing: identification of epithelial-specific splicing factors. 25 Mar 2009
• ESRP1 and ESRP2 are epithelial cell-type-specific regulators of FGFR2 splicing. 11 Mar 2009
• FGF4 and retinoic acid direct differentiation of hESCs into PDX1-expressing foregut endoderm in a time- and concentration-dependent manner. 9 Mar 2009

See a longer list of these articles.

Technical information about 'Receptor, Fibroblast Growth Factor, Type 2'

Definition: A fibroblast growth factor receptor that is found in two isoforms. One receptor isoform is found in the MESENCHYME and is activated by FIBROBLAST GROWTH FACTOR 2. A second isoform of fibroblast growth factor receptor 2 is found mainly in EPITHELIAL CELLS and is activated by FIBROBLAST GROWTH FACTOR 7 and FIBROBLAST GROWTH FACTOR 10. Mutation of the gene for fibroblast growth factor receptor 2 can result in APERT SYNDROME.

Registry Number: EC 2.7.1.112

Descriptor UI: D051497

Alternative terms: Receptor, Fibroblast Growth Factor, Type 2; BEK Protein Tyrosine Kinase; Bek Fgf Receptor Kinase; FGFR2 Protein; Fibroblast Growth Factor Receptor 2; Bek-Related Fibroblast Growth Factor-Receptor-1; Bek Related Fibroblast Growth Factor Receptor 1; Fibroblast Growth Factor Receptors 2; BEK Fibroblast Growth Factor Receptor; BEK Fibroblast Growth Factor Receptor Kinase; Fibroblast Growth Factor Receptor 2c; Receptor, Fibroblast Growth Factor 2c; FGFR2c; Fibroblast Growth Factor Receptor 2b; Receptor, Fibroblast Growth Factor 2b; FGFR2b; Fibroblast Growth Factor Receptors 2b;

Related Mesh Headings: Acrocephalosyndactylia;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D08.811.913.696.620.682.725.400.178; D12.776.543.750.060.441; D12.776.543.750.750.400.370.750;

History Note: 2006(1999)