Receptor, Platelet-Derived Growth Factor beta
Research News and Information

Monday, November 23, 2009

Additive effects of hyperbaric oxygen and platelet-derived growth factor-BB in chondrocyte transplantation via up-regulation expression of platelet-derived growth factor-beta receptor.

30 Oct 2009 The present study investigated the effects of hyperbaric oxygen (HBO) and platelet-derived growth factor-BB (PDGF-BB) in chondrocyte transplantation. In vitro, chondrocytes were treated with HBO, PDGF-BB, and HBO combined with PDGF-BB (H+P). Cell ... Read more...

Radiosensitization effect of STI-571 on pancreatic cancer cells in vitro.

30 Oct 2009 PURPOSE: To examine STI-571-induced radiosensitivity in human pancreatic cancer cells in vitro. METHODS AND MATERIALS: Three human pancreatic cancer cell lines (Bxpc-3, Capan-1, and MiaPaCa-2) exhibiting different expression levels of c-Kit and ... Read more...

Shortening of human cell life span by induction of p16ink4a through the platelet-derived growth factor receptor beta.

30 Oct 2009 Mesenchymal stem cells (MSCs) are attracting a great deal of attention because they represent a valuable source of cells for use in regenerative medicine. In human cell culture it is important to obtain large numbers of cells for use in therapy. In ... Read more...

Latest indexed articles for 'Receptor, Platelet-Derived Growth Factor beta'

These are the very latest articles for this heading:

• Additive effects of hyperbaric oxygen and platelet-derived growth factor-BB in chondrocyte transplantation via up-regulation expression of platelet-derived growth factor-beta receptor. 30 Oct 2009
• Radiosensitization effect of STI-571 on pancreatic cancer cells in vitro. 30 Oct 2009
• Shortening of human cell life span by induction of p16ink4a through the platelet-derived growth factor receptor beta. 30 Oct 2009
• Trisomy 8 in PDGFRB-negative cells in a patient with imatinib-sensitive chronic myelomonocytic leukemia and t(5;16)(q33;p13), PDGFRB-NDE1 fusion. 29 Sep 2009
• VEGF-C regulates lymphangiogenesis and capillary stability by regulation of PDGF-B. 2 Sep 2009
• Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. 15 Aug 2009
• Therapeutic targeting of the PDGF and TGF-beta-signaling pathways in hepatic stellate cells by PTK787/ZK22258. 8 Aug 2009
• Inactivation of the LRP1 intracellular NPxYxxL motif in LDLR-deficient mice enhances postprandial dyslipidemia and atherosclerosis. 8 Aug 2009
• (-)-Epigallocatechin gallate prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFRbeta and IGF-1R. 28 Jul 2009
• Phase I dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-Kit, in patients with advanced or metastatic solid tumors. 25 Jul 2009
• Artificial transmembrane oncoproteins smaller than the bovine papillomavirus E5 protein redefine sequence requirements for activation of the platelet-derived growth factor beta receptor. 13 Jul 2009
• Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma. 13 Jul 2009
• Syndecan-1: an inhibitor of arterial smooth muscle cell growth and intimal hyperplasia. 8 Jul 2009
• Effects of lipopolysaccharide on platelet-derived growth factor isoform and receptor expression in cultured rat common bile duct fibroblasts and cholangiocytes. 29 Jun 2009
• Hypoxic ventilatory response in platelet-derived growth factor receptor-beta-knockout mice. 17 Jun 2009
• PDGFR inhibition in brain tumours--oft expectation fails where most it promises. 16 Jun 2009
• Krüppel-like factor 4 inhibits proliferation by platelet-derived growth factor receptor beta-mediated, not by retinoic acid receptor alpha-mediated, phosphatidylinositol 3-kinase and ERK signaling in vascular smooth muscle cells. 14 Jun 2009
• Cell migration is regulated by platelet-derived growth factor receptor endocytosis. 13 Jun 2009
• Urokinase activates macrophage PON2 gene transcription via the PI3K/ROS/MEK/SREBP-2 signalling cascade mediated by the PDGFR-beta. 2 Jun 2009
• Two different PDGF beta-receptor cohorts in human pericytes mediate distinct biological endpoints. 2 Jun 2009

See a longer list of these articles.

Technical information about 'Receptor, Platelet-Derived Growth Factor beta'

Definition: A PDGF receptor that binds specifically to the PDGF-B chain. It contains a protein-tyrosine kinase activity that is involved in SIGNAL TRANSDUCTION.

Registry Number: EC 2.7.1.112

Descriptor UI: D020797

Alternative terms: Receptor, Platelet-Derived Growth Factor beta; Receptor, Platelet Derived Growth Factor beta; PDGF beta Receptor; Platelet-Derived Growth Factor beta Receptor; Platelet Derived Growth Factor beta Receptor; CD140b Antigen; Antigen, CD140b; CD140b Antigens; PDGFR1; PDGFR beta; beta, PDGFR; Receptor, PDGF beta; PDGFRB; Antigens, CD140b;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D08.811.913.696.620.682.725.400.900.750; D12.776.543.750.060.625.400; D12.776.543.750.750.400.630.400;

History Note: 2000; use RECEPTOR, PDGF BETA (NM) 1994-1999

Technical Notes: DF: PDGF BETA RECEPT