Receptor, Serotonin, 5-HT1A - Agonists
Research News and Information

Sunday, November 22, 2009

Alteration of synaptic transmission in the hippocampal-mPFC pathway during extinction trials of context-dependent fear memory in juvenile rat stress models.

30 Aug 2009 The medial prefrontal cortex (mPFC) has been proposed to be essential for extinction of fear memory, but its neural mechanism has been poorly understood. The present study examined whether synaptic transmission in the hippocampal-mPFC pathway is ... Read more...

Treatment of cognitive dysfunction in chronic schizophrenia by augmentation of atypical antipsychotics with buspirone, a partial 5-HT(1A) receptor agonist.

30 Jul 2009 OBJECTIVES: To assess effects of a semi-acute administration of buspirone in comparison to a placebo on cognitive function and negative symptoms in patients with schizophrenia and schizoaffective disorder. METHODS: In a 6-week, double-blind, ... Read more...

Role of spinal serotonergic pathways in sneeze-induced urethral continence reflex in rats.

27 Jul 2009 To clarify the role of spinal serotonergic mechanisms in preventing stress urinary incontinence (SUI) during sneezing, we investigated the effect of intrathecal (it) application of 8-OH-DPAT (a 5-HT(1A) agonist), mCPP (a 5-HT(2B/2C) agonist), and ... Read more...

Latest indexed articles for 'Receptor, Serotonin, 5-HT1A - Agonists'

These are the very latest articles for this heading:

• Alteration of synaptic transmission in the hippocampal-mPFC pathway during extinction trials of context-dependent fear memory in juvenile rat stress models. 30 Aug 2009
• Treatment of cognitive dysfunction in chronic schizophrenia by augmentation of atypical antipsychotics with buspirone, a partial 5-HT(1A) receptor agonist. 30 Jul 2009
• Role of spinal serotonergic pathways in sneeze-induced urethral continence reflex in rats. 27 Jul 2009
• Implication of the 5-HT2A and 5-HT2C (but not 5HT1A) receptors located within the periaqueductal gray in the elevated plus-maze test-retest paradigm in mice. 17 Jul 2009
• Neither in vivo MRI nor behavioural assessment indicate therapeutic efficacy for a novel 5HT(1A) agonist in rat models of ischaemic stroke. 14 Jul 2009
• 'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity. 14 Jun 2009
• The contribution of serotonin 1A receptors to kappa opioid immunosuppression. 9 Jun 2009
• Inhibition of the cardiovascular response to stress by systemic 5-HT1A activation: sympathoinhibition or anxiolysis? 8 Jun 2009
• Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT1A and 5-HT1B receptor agonists in the rat Parkinson model. Jun 2009
• 5-HT1A receptor activation is necessary for 5-MeODMT-dependent potentiation of feeding inhibition. 29 May 2009
• Effect of buspirone on thermal sensory and pain thresholds in human volunteers. 27 May 2009
• Early postnatal stress affects 5-HT1A receptor function in the medial prefrontal cortex in adult rats. 22 May 2009
• Contribution of the striatum to the effects of 5-HT1A receptor stimulation in L-DOPA-treated hemiparkinsonian rats. 13 May 2009
• The firing activity of pyramidal neurons in medial prefrontal cortex and their response to 5-hydroxytryptamine-1A receptor stimulation in a rat model of Parkinson's disease. 2 May 2009
• Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity. 21 Apr 2009
• Effects of tandospirone, a 5-HT1A agonistic anxiolytic agent, on haloperidol-induced catalepsy and forebrain Fos expression in mice. 5 Apr 2009
• F15063, a potential antipsychotic with dopamine D2/D3 receptor antagonist, 5-HT1A receptor agonist and dopamine D4 receptor partial agonist properties: influence on neuronal firing and neurotransmitter release. 30 Mar 2009
• Inhibitory effects of osemozotan, a serotonin 1A-receptor agonist, on methamphetamine-induced c-Fos expression in prefrontal cortical neurons. 30 Mar 2009
• The counteraction of opioid-induced ventilatory depression by the serotonin 1A-agonist 8-OH-DPAT does not antagonize antinociception in rats in situ and in vivo. 30 Mar 2009
• Memory time-course: mRNA 5-HT1A and 5-HT7 receptors. 26 Mar 2009

See a longer list of these articles.

Technical information about 'Receptor, Serotonin, 5-HT1A'

Definition: A serotonin receptor subtype found distributed through the CENTRAL NERVOUS SYSTEM where they are involved in neuroendocrine regulation of ACTH secretion. The fact that this serotonin receptor subtype is particularly sensitive to SEROTONIN AGONISTS such as BUSPIRONE suggests its role in the modulation of ANXIETY and DEPRESSION.

Registry Number: 112692-38-3

Descriptor UI: D044282

Alternative terms: Receptor, Serotonin, 5-HT1A; 5-HT1A Receptor; 5 HT1A Receptor; Receptor, 5-HT1A; 5-Hydroxytryptamine 1A Receptor; 1A Receptor, 5-Hydroxytryptamine; 5 Hydroxytryptamine 1A Receptor; 5-Hydroxytryptamine 1A Receptors; 1A Receptors, 5-Hydroxytryptamine; 5 Hydroxytryptamine 1A Receptors; Receptors, 5-Hydroxytryptamine 1A; Serotonin, 5-HT1a Receptor; 5-HT1a Receptor Serotonin; Receptor Serotonin, 5-HT1a; Serotonin, 5 HT1a Receptor; Serotonin 1A Receptor; 1A Receptor, Serotonin; Receptor, Serotonin 1A; Serotonin Receptor, 5-HT1A; 5-HT1A Serotonin Receptor; Receptor, 5-HT1A Serotonin; Serotonin Receptor, 5 HT1A; 5-HT(1A) Receptor; Receptor, 5-Hydroxytryptamine 1A; Receptor, 5 Hydroxytryptamine 1A;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.070.800.100.100; D12.776.543.750.100.800.100.100; D12.776.543.750.720.300.800.100.100;

History Note: 2004; use RECEPTOR SEROTONIN 5 HT1 SUBCLASS (NM) 1993-2003