Receptor, Serotonin, 5-HT1A - Drug effects
Research News and Information

Sunday, November 22, 2009

Differential effects of M1 and 5-hydroxytryptamine1A receptors on atypical antipsychotic drug-induced dopamine efflux in the medial prefrontal cortex.

31 May 2009 Systemic administration of the M(1) receptor agonists N-desmethylclozapine (NDMC) and 4-[3-(4-butylpiperidin-1-yl)-propyl]-7-fluoro-4H-benzo[1,4]oxazin-3-one (AC260584) increase dopamine (DA) efflux in rat medial prefrontal cortex (mPFC). This ... Read more...

Nicotine exposure in adolescence alters the response of serotonin systems to nicotine administered subsequently in adulthood.

15 Apr 2009 Developmental nicotine exposure produces lasting changes in serotonin (5-HT) function. We gave nicotine to adolescent rats (postnatal days, PD, 30-47), simulating plasma levels in smokers, and then examined the subsequent effects of nicotine given ... Read more...

Perinatal malnutrition programs sustained alterations in nitric oxide released by activated macrophages in response to fluoxetine in adult rats.

7 Apr 2009 OBJECTIVE: Nutritional restriction during lactation has long-term consequences on the functioning of neuroimmune systems. Receptors and transporter serotonin (5-HT) are present in macrophages and may influence their role. This study evaluated nitric ... Read more...

Latest indexed articles for 'Receptor, Serotonin, 5-HT1A - Drug effects'

These are the very latest articles for this heading:

• Selective serotonin reuptake inhibitor-induced spermatorrhea in 2 patients. 30 Jul 2009
• Differential effects of M1 and 5-hydroxytryptamine1A receptors on atypical antipsychotic drug-induced dopamine efflux in the medial prefrontal cortex. 31 May 2009
• Nicotine exposure in adolescence alters the response of serotonin systems to nicotine administered subsequently in adulthood. 15 Apr 2009
• Perinatal malnutrition programs sustained alterations in nitric oxide released by activated macrophages in response to fluoxetine in adult rats. 7 Apr 2009
• CTN-986, a compound extracted from cottonseeds, increases cell proliferation in hippocampus in vivo and in cultured neural progenitor cells in vitro. 30 Mar 2009
• Local administration of sarizotan into the subthalamic nucleus attenuates levodopa-induced dyskinesias in 6-OHDA-lesioned rats. 20 Jan 2009
• Effects of SNS activation on SSRI-induced sexual side effects differ by SSRI. 30 Dec 2008
• Synthesis and pharmacological evaluation of aminopyrimidine series of 5-HT1A partial agonists. 23 Dec 2008
• Early deprivation leads to long-term reductions in motivation for reward and 5-HT1A binding and both effects are reversed by fluoxetine. 22 Dec 2008
• Characterization of serotonin receptors in pregnant human myometrium. 13 Dec 2008
• 2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties. 9 Dec 2008
• 5-HT(1A) and 5-HT(1B) receptors in the ventrolateral striatum differentially modulate apomorphine-induced jaw movements in rats. 29 Nov 2008
• Allosteric modulation of 5-HT(1A) receptors by zinc: Binding studies. 12 Oct 2008
• Neurokinin-1 receptor antagonists modulate brain noradrenaline and serotonin interactions. 7 Oct 2008
• WAY100635 prevents the changes induced by fluoxetine upon the 5-HT1A receptor functionality. 15 Sep 2008
• Cocaine conditioning: reversal by autoreceptor dose levels of 8-OHDPAT. 7 Sep 2008
• Antidepressant-like effects of sodium butyrate in combination with estrogen in rat forced swimming test: involvement of 5-HT(1A) receptors. 2 Sep 2008
• Role of serotonin-1A receptors in the action of antipsychotic drugs: comparison of prepulse inhibition studies in mice and rats and relevance for human pharmacology. 30 Aug 2008
• A role for the 5-HT(1A), 5-HT4 and 5-HT6 receptors in learning and memory. 30 Aug 2008
• Stimulation of 5-HT1A or 5-HT2A receptors in the ventrolateral periaqueductal gray causes anxiolytic-, but not panicolytic-like effect in rats. 27 Aug 2008

See a longer list of these articles.

Technical information about 'Receptor, Serotonin, 5-HT1A'

Definition: A serotonin receptor subtype found distributed through the CENTRAL NERVOUS SYSTEM where they are involved in neuroendocrine regulation of ACTH secretion. The fact that this serotonin receptor subtype is particularly sensitive to SEROTONIN AGONISTS such as BUSPIRONE suggests its role in the modulation of ANXIETY and DEPRESSION.

Registry Number: 112692-38-3

Descriptor UI: D044282

Alternative terms: Receptor, Serotonin, 5-HT1A; 5-HT1A Receptor; 5 HT1A Receptor; Receptor, 5-HT1A; 5-Hydroxytryptamine 1A Receptor; 1A Receptor, 5-Hydroxytryptamine; 5 Hydroxytryptamine 1A Receptor; 5-Hydroxytryptamine 1A Receptors; 1A Receptors, 5-Hydroxytryptamine; 5 Hydroxytryptamine 1A Receptors; Receptors, 5-Hydroxytryptamine 1A; Serotonin, 5-HT1a Receptor; 5-HT1a Receptor Serotonin; Receptor Serotonin, 5-HT1a; Serotonin, 5 HT1a Receptor; Serotonin 1A Receptor; 1A Receptor, Serotonin; Receptor, Serotonin 1A; Serotonin Receptor, 5-HT1A; 5-HT1A Serotonin Receptor; Receptor, 5-HT1A Serotonin; Serotonin Receptor, 5 HT1A; 5-HT(1A) Receptor; Receptor, 5-Hydroxytryptamine 1A; Receptor, 5 Hydroxytryptamine 1A;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.070.800.100.100; D12.776.543.750.100.800.100.100; D12.776.543.750.720.300.800.100.100;

History Note: 2004; use RECEPTOR SEROTONIN 5 HT1 SUBCLASS (NM) 1993-2003