Receptor, Serotonin, 5-HT1A - Genetics
Research News and Information

Sunday, November 22, 2009

Membrane cholesterol depletion from live cells enhances the function of human serotonin(1A) receptors.

29 Aug 2009 Work from our laboratory has previously demonstrated the requirement of membrane cholesterol in the function of the serotonin(1A) receptor, a member of the G-protein coupled receptor (GPCR) superfamily. In order to monitor the effect of cellular ... Read more...

5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression.

3 Aug 2009 Genes that regulate the serotonin signalling system are potential targets for research in the aetiology of mood disorders and also in the treatment response of serotonin reuptake inhibitors. In this study, we evaluated the association of seven ... Read more...

Activity of the 5-HT1A receptor is involved in the alteration of glucocorticoid receptor in hippocampus and corticotropin-releasing factor in hypothalamus in SPS rats.

30 Jul 2009 Rats exposed to single-prolonged stress (SPS) showed enhanced inhibition of the hypothalamic-pituitary-adrenal (HPA) system and alteration in the glucocorticoid/mineralocorticoid receptor. Dysfunction of the HPA axis is one of the core ... Read more...

Latest indexed articles for 'Receptor, Serotonin, 5-HT1A - Genetics'

These are the very latest articles for this heading:

• Membrane cholesterol depletion from live cells enhances the function of human serotonin(1A) receptors. 29 Aug 2009
• 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression. 3 Aug 2009
• Activity of the 5-HT1A receptor is involved in the alteration of glucocorticoid receptor in hippocampus and corticotropin-releasing factor in hypothalamus in SPS rats. 30 Jul 2009
• Differential dynamics of membrane proteins in yeast. 14 Jul 2009
• Mutant 5-hydroxytryptamine 1A receptor D116A is a receptor activated solely by synthetic ligands with a rich pharmacology. 13 Jul 2009
• [Development of serotonergic neurons of dorsal raphe nuclei in mice with knockout of monoamine oxidase A and 5-HT1A and 5-HT1B autoreceptor] 29 Jun 2009
• Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder. 24 Jun 2009
• Characterization of serotonin 5-hydroxytryptamine-1A receptor activation using a phospho-extracellular-signal regulated kinase 2 sensor. 15 Jun 2009
• [Association of several polymorphic loci of serotoninergic genes with unipolar depression] 30 May 2009
• Elevated serotonin 1A binding in remitted major depressive disorder: evidence for a trait biological abnormality. 18 May 2009
• Human Freud-2/CC2D1B: a novel repressor of postsynaptic serotonin-1A receptor expression. 5 May 2009
• Expression patterns of 5-HT receptor subtypes 1A and 2A on GABAergic neurons within the spinal dorsal horn of GAD67-GFP knock-in mice. May 2009
• Aggressive encounters alter the activation of serotonergic neurons and the expression of 5-HT1A mRNA in the hamster dorsal raphe nucleus. 7 Apr 2009
• Genetic variation of serotonin receptor function affects prepulse inhibition of the startle. 6 Apr 2009
• Positron emission tomography quantification of serotonin-1A receptor binding in medication-free bipolar depression. 15 Mar 2009
• Expression of 5-HT1A and 5-HT7 receptors in Caco-2 cells and their role in the regulation of serotonin transporter activity. 27 Feb 2009
• Suicide, stress and serotonin receptor 1A promoter polymorphism -1019C>G in Slovenian suicide victims. 15 Feb 2009
• Molecular characterization and analysis of a truncated serotonin receptor gene expressed in neural and reproductive tissues of abalone. 11 Feb 2009
• [5-HT1A gene polymorphisms contributed to antidepressant response in major depression] 30 Jan 2009
• Could serotonin play a role in sudden infant death? 30 Jan 2009

See a longer list of these articles.

Technical information about 'Receptor, Serotonin, 5-HT1A'

Definition: A serotonin receptor subtype found distributed through the CENTRAL NERVOUS SYSTEM where they are involved in neuroendocrine regulation of ACTH secretion. The fact that this serotonin receptor subtype is particularly sensitive to SEROTONIN AGONISTS such as BUSPIRONE suggests its role in the modulation of ANXIETY and DEPRESSION.

Registry Number: 112692-38-3

Descriptor UI: D044282

Alternative terms: Receptor, Serotonin, 5-HT1A; 5-HT1A Receptor; 5 HT1A Receptor; Receptor, 5-HT1A; 5-Hydroxytryptamine 1A Receptor; 1A Receptor, 5-Hydroxytryptamine; 5 Hydroxytryptamine 1A Receptor; 5-Hydroxytryptamine 1A Receptors; 1A Receptors, 5-Hydroxytryptamine; 5 Hydroxytryptamine 1A Receptors; Receptors, 5-Hydroxytryptamine 1A; Serotonin, 5-HT1a Receptor; 5-HT1a Receptor Serotonin; Receptor Serotonin, 5-HT1a; Serotonin, 5 HT1a Receptor; Serotonin 1A Receptor; 1A Receptor, Serotonin; Receptor, Serotonin 1A; Serotonin Receptor, 5-HT1A; 5-HT1A Serotonin Receptor; Receptor, 5-HT1A Serotonin; Serotonin Receptor, 5 HT1A; 5-HT(1A) Receptor; Receptor, 5-Hydroxytryptamine 1A; Receptor, 5 Hydroxytryptamine 1A;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.070.800.100.100; D12.776.543.750.100.800.100.100; D12.776.543.750.720.300.800.100.100;

History Note: 2004; use RECEPTOR SEROTONIN 5 HT1 SUBCLASS (NM) 1993-2003