Receptor, Serotonin, 5-HT1A
Research News and Information

Saturday, November 21, 2009

Physical binding pocket induction for affinity prediction.

6 Oct 2009 Computational methods for predicting ligand affinity where no protein structure is known generally take the form of regression analysis based on molecular features that have only a tangential relationship to a protein/ligand binding event. Such ... Read more...

5-HT 1A and 2A receptor positive cells in the cerebella of mice and human and their decline during aging.

30 Aug 2009 This study evaluated the 5-HT1A and 5-HT2A receptor positive cells in the cerebella of mice and human by immunocytochemistry. Mice were of ages 1, 3, and 12 months whereas the human subjects were divided into two groups, a younger 57-78 years old ... Read more...

Alteration of synaptic transmission in the hippocampal-mPFC pathway during extinction trials of context-dependent fear memory in juvenile rat stress models.

30 Aug 2009 The medial prefrontal cortex (mPFC) has been proposed to be essential for extinction of fear memory, but its neural mechanism has been poorly understood. The present study examined whether synaptic transmission in the hippocampal-mPFC pathway is ... Read more...

Latest indexed articles for 'Receptor, Serotonin, 5-HT1A'

These are the very latest articles for this heading:

• Physical binding pocket induction for affinity prediction. 6 Oct 2009
• 5-HT 1A and 2A receptor positive cells in the cerebella of mice and human and their decline during aging. 30 Aug 2009
• Alteration of synaptic transmission in the hippocampal-mPFC pathway during extinction trials of context-dependent fear memory in juvenile rat stress models. 30 Aug 2009
• Membrane cholesterol depletion from live cells enhances the function of human serotonin(1A) receptors. 29 Aug 2009
• Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists. 11 Aug 2009
• Layer II/III of the prefrontal cortex: Inhibition by the serotonin 5-HT1A receptor in development and stress. 10 Aug 2009
• 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression. 3 Aug 2009
• Treatment of cognitive dysfunction in chronic schizophrenia by augmentation of atypical antipsychotics with buspirone, a partial 5-HT(1A) receptor agonist. 30 Jul 2009
• Selective serotonin reuptake inhibitor-induced spermatorrhea in 2 patients. 30 Jul 2009
• Aggression is related to frontal serotonin-1A receptor distribution as revealed by PET in healthy subjects. 30 Jul 2009
• Activity of the 5-HT1A receptor is involved in the alteration of glucocorticoid receptor in hippocampus and corticotropin-releasing factor in hypothalamus in SPS rats. 30 Jul 2009
• Role of spinal serotonergic pathways in sneeze-induced urethral continence reflex in rats. 27 Jul 2009
• Implication of the 5-HT2A and 5-HT2C (but not 5HT1A) receptors located within the periaqueductal gray in the elevated plus-maze test-retest paradigm in mice. 17 Jul 2009
• Parametric mapping of 5HT1A receptor sites in the human brain with the Hypotime method: theory and normal values. 15 Jul 2009
• Neither in vivo MRI nor behavioural assessment indicate therapeutic efficacy for a novel 5HT(1A) agonist in rat models of ischaemic stroke. 14 Jul 2009
• Differential dynamics of membrane proteins in yeast. 14 Jul 2009
• Mutant 5-hydroxytryptamine 1A receptor D116A is a receptor activated solely by synthetic ligands with a rich pharmacology. 13 Jul 2009
• Locomotor-activated neurons of the cat. I. Serotonergic innervation and co-localization of 5-HT7, 5-HT2A, and 5-HT1A receptors in the thoraco-lumbar spinal cord. 29 Jun 2009
• [Development of serotonergic neurons of dorsal raphe nuclei in mice with knockout of monoamine oxidase A and 5-HT1A and 5-HT1B autoreceptor] 29 Jun 2009
• Enhancement of the function of rat serotonin and norepinephrine neurons by sustained vagus nerve stimulation. 29 Jun 2009

See a longer list of these articles.

Technical information about 'Receptor, Serotonin, 5-HT1A'

Definition: A serotonin receptor subtype found distributed through the CENTRAL NERVOUS SYSTEM where they are involved in neuroendocrine regulation of ACTH secretion. The fact that this serotonin receptor subtype is particularly sensitive to SEROTONIN AGONISTS such as BUSPIRONE suggests its role in the modulation of ANXIETY and DEPRESSION.

Registry Number: 112692-38-3

Descriptor UI: D044282

Alternative terms: Receptor, Serotonin, 5-HT1A; 5-HT1A Receptor; 5 HT1A Receptor; Receptor, 5-HT1A; 5-Hydroxytryptamine 1A Receptor; 1A Receptor, 5-Hydroxytryptamine; 5 Hydroxytryptamine 1A Receptor; 5-Hydroxytryptamine 1A Receptors; 1A Receptors, 5-Hydroxytryptamine; 5 Hydroxytryptamine 1A Receptors; Receptors, 5-Hydroxytryptamine 1A; Serotonin, 5-HT1a Receptor; 5-HT1a Receptor Serotonin; Receptor Serotonin, 5-HT1a; Serotonin, 5 HT1a Receptor; Serotonin 1A Receptor; 1A Receptor, Serotonin; Receptor, Serotonin 1A; Serotonin Receptor, 5-HT1A; 5-HT1A Serotonin Receptor; Receptor, 5-HT1A Serotonin; Serotonin Receptor, 5 HT1A; 5-HT(1A) Receptor; Receptor, 5-Hydroxytryptamine 1A; Receptor, 5 Hydroxytryptamine 1A;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.070.800.100.100; D12.776.543.750.100.800.100.100; D12.776.543.750.720.300.800.100.100;

History Note: 2004; use RECEPTOR SEROTONIN 5 HT1 SUBCLASS (NM) 1993-2003