Receptor, Serotonin, 5-HT2A - Agonists
Research News and Information

Sunday, November 22, 2009

Assessment of binding affinity to 5-hydroxytryptamine 2A (5-HT2A) receptor and inverse agonist activity of naftidrofuryl: comparison with those of sarpogrelate.

30 Jul 2009 Naftidrofuryl is a peripheral vasodilator that has been clinically used in the treatment of intermittent claudication and dementia. It has 5-hydroxytryptamine 2 (5-HT(2)) antiserotonergic activity and selectively binds with the 5-HT(2) receptor. The ... Read more...

Implication of the 5-HT2A and 5-HT2C (but not 5HT1A) receptors located within the periaqueductal gray in the elevated plus-maze test-retest paradigm in mice.

17 Jul 2009 A single exposure to the elevated plus-maze test (EPM) increases open arms avoidance and reduces or abolishes the anxiolytic-like effect of benzodiazepines assessed during a second trial, a phenomenon defined as "one-trial tolerance" (OTT). It has ... Read more...

5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations.

25 May 2009 Vocalizations of male and female African clawed frogs (Xenopus laevis) are generated by brain stem central pattern generators. Serotonin (5-HT) is likely important for vocal initiation because, when applied in vitro, sex-typical fictive ... Read more...

Latest indexed articles for 'Receptor, Serotonin, 5-HT2A - Agonists'

These are the very latest articles for this heading:

• Assessment of binding affinity to 5-hydroxytryptamine 2A (5-HT2A) receptor and inverse agonist activity of naftidrofuryl: comparison with those of sarpogrelate. 30 Jul 2009
• Implication of the 5-HT2A and 5-HT2C (but not 5HT1A) receptors located within the periaqueductal gray in the elevated plus-maze test-retest paradigm in mice. 17 Jul 2009
• 5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations. 25 May 2009
• 5-HT(2A) and 5-HT(2C) receptors exert opposing effects on locomotor activity in mice. 23 Mar 2009
• Psychedelics and schizophrenia. 3 Mar 2009
• Reduced sensitivity to the locomotor-stimulant effects of cocaine is associated with increased sensitivity to its discriminative stimulus properties. 30 Jan 2009
• Electrophysiological characterization of the effects of asenapine at 5-HT(1A), 5-HT(2A), alpha(2)-adrenergic and D(2) receptors in the rat brain. 27 Dec 2008
• Current status of inverse agonism at serotonin2A (5-HT2A) and 5-HT2C receptors. 4 Dec 2008
• Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors. 3 Dec 2008
• APD125, a selective serotonin 5-HT(2A) receptor inverse agonist, significantly improves sleep maintenance in primary insomnia. 29 Nov 2008
• Pimavanserin tartrate: a 5-HT2A inverse agonist with potential for treating various neuropsychiatric disorders. 29 Nov 2008
• Repeated adolescent MDMA ("Ecstasy") exposure in rats increases behavioral and neuroendocrine responses to a 5-HT2A/2C agonist. 23 Nov 2008
• Potential modes of interaction of 9-aminomethyl-9,10-dihydroanthracene (AMDA) derivatives with the 5-HT2A receptor: a ligand structure-affinity relationship, receptor mutagenesis and receptor modeling investigation. 9 Oct 2008
• A 5-HT2A receptor inverse agonist, ACP-103, reduces tremor in a rat model and levodopa-induced dyskinesias in a monkey model. 29 Sep 2008
• Prenatal activation of 5-HT2A receptor induces expression of 5-HT1B receptor in phrenic motoneurons and alters the organization of their premotor network in newborn mice. 7 Sep 2008
• Structure-activity relationships of phenylalkylamines as agonist ligands for 5-HT(2A) receptors. 30 Aug 2008
• Serotonin 5-hydroxytryptamine(2A) receptor activation suppresses tumor necrosis factor-alpha-induced inflammation with extraordinary potency. 13 Aug 2008
• Morphine desensitization, internalization, and down-regulation of the mu opioid receptor is facilitated by serotonin 5-hydroxytryptamine2A receptor coactivation. 12 Aug 2008
• Agonist-directed trafficking of signalling at serotonin 5-HT2A, 5-HT2B and 5-HT2C-VSV receptors mediated Gq/11 activation and calcium mobilisation in CHO cells. 28 Jul 2008
• Airway smooth muscle relaxation induced by 5-HT(2A) receptors: role of Na(+)/K(+)-ATPase pump and Ca(2+)-activated K(+) channels. 23 Jul 2008

See a longer list of these articles.

Technical information about 'Receptor, Serotonin, 5-HT2A'

Definition: A serotonin receptor subtype found widely distributed in peripheral tissues where it mediates the contractile responses of variety of tissues that contain SMOOTH MUSCLE. Selective 5-HT2A receptor antagonists include KETANSERIN. The 5-HT2A subtype is also located in BASAL GANGLIA and CEREBRAL CORTEX of the BRAIN where it mediates the effects of HALLUCINOGENS such as LSD.

Registry Number: 0

Descriptor UI: D044402

Alternative terms: Receptor, Serotonin, 5-HT2A; 5-HT2A Receptor; 5 HT2A Receptor; Receptor, 5-HT2A; Serotonin 2A Receptors; 2A Receptors, Serotonin; Receptors, Serotonin 2A; Serotonin 2A Receptor; 5-HT(2A) Receptor; Receptor, Serotonin 2A; 2A Receptor, Serotonin;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.070.800.200.100; D12.776.543.750.100.800.200.100; D12.776.543.750.720.300.800.200.100;

History Note: 2004; use RECEPTOR, SEROTONIN, 5-HT2A (NM) 1994-2003