Receptor, Serotonin, 5-HT2A - Antagonists & inhibitors
Research News and Information

Monday, November 23, 2009

Association between the use of serotonin receptor 2A-blocking antidepressants and joint disorders.

13 Oct 2009 OBJECTIVE: There are case reports about antidepressants causing arthritis and arthralgia, and the majority of these reports deal with atypical antidepressants, which are serotonin receptor 2A (5-HT(2A))-blocking substances. The aim of this study was ... Read more...

Mechanisms by which the serotonergic system inhibits micturition in rats.

31 Aug 2009 AIMS: Serotonergic neurons and amino acid neurons are involved in the central nervous control of lower urinary tract function. We investigated the role of the serotonergic system in the central regulation of micturition, as well as the relationship ... Read more...

[Pharmacological studies on responsiveness of 5-hydroxytryptamine in overcoming perioperative spasm of coronary artery bypass graft]

30 Aug 2009 In ischemic heart diseases, the use of the internal thoracic artery (ITA) as an arterial graft has been associated with longer survival and better quality of life. However, it has been reported that vasospasm of the ITA graft frequently occurs and ... Read more...

Latest indexed articles for 'Receptor, Serotonin, 5-HT2A - Antagonists & inhibitors'

These are the very latest articles for this heading:

• Association between the use of serotonin receptor 2A-blocking antidepressants and joint disorders. 13 Oct 2009
• Mechanisms by which the serotonergic system inhibits micturition in rats. 31 Aug 2009
• [Pharmacological studies on responsiveness of 5-hydroxytryptamine in overcoming perioperative spasm of coronary artery bypass graft] 30 Aug 2009
• Inhibitory effect of serotonin antagonists on JC virus propagation in a carrier culture of human neuroblastoma cells. 30 Aug 2009
• Chronic treatment of hydroxytryptamine type 2a receptor antagonist sarpogrelate hydrochloride modulates the vasoreactivity of serotonin in experimental rabbit vein grafts. 30 Aug 2009
• Assessment of binding affinity to 5-hydroxytryptamine 2A (5-HT2A) receptor and inverse agonist activity of naftidrofuryl: comparison with those of sarpogrelate. 30 Jul 2009
• APD791, 3-methoxy-n-(3-(1-methyl-1h-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide, a novel 5-hydroxytryptamine 2A receptor antagonist: pharmacological profile, pharmacokinetics, platelet activity and vascular biology. 21 Jul 2009
• Sulfonamides with the N-alkyl-N'-dialkylguanidine moiety as 5-HT7 receptor ligands. 11 Jun 2009
• cis-Urocanic acid stimulates primary human keratinocytes independently of serotonin or platelet-activating factor receptors. 26 May 2009
• 5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations. 25 May 2009
• Assessment of 5-hydroxytryptamine efflux in rat brain during a mild, moderate and severe serotonin-toxicity syndrome. 18 May 2009
• (1R, 3S)-(-)-trans-PAT: a novel full-efficacy serotonin 5-HT2C receptor agonist with 5-HT2A and 5-HT2B receptor inverse agonist/antagonist activity. May 2009
• Antagonism of serotonergic 5-HT2A/2C receptors: mutual improvement of sleep, cognition and mood? 26 Apr 2009
• Blockade of the serotonin 5-HT2A receptor suppresses cue-evoked reinstatement of cocaine-seeking behavior in a rat self-administration model. 30 Mar 2009
• Acute effects of sarpogrelate, a 5-HT2A receptor antagonist on cytokine production in endotoxin shock model of rats. 22 Mar 2009
• (+/-)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congeners. 14 Mar 2009
• Evidence for distinct antagonist-revealed functional states of 5-hydroxytryptamine(2A) receptor homodimers. 9 Mar 2009
• Sarpogrelate hydrochloride reduced intimal hyperplasia in experimental rabbit vein graft. 21 Feb 2009
• Evidence that oxytocin exerts anxiolytic effects via oxytocin receptor expressed in serotonergic neurons in mice. 16 Feb 2009
• Repeated cocaine administration decreases 5-HT(2A) receptor-mediated serotonergic enhancement of synaptic activity in rat medial prefrontal cortex. 9 Feb 2009

See a longer list of these articles.

Technical information about 'Receptor, Serotonin, 5-HT2A'

Definition: A serotonin receptor subtype found widely distributed in peripheral tissues where it mediates the contractile responses of variety of tissues that contain SMOOTH MUSCLE. Selective 5-HT2A receptor antagonists include KETANSERIN. The 5-HT2A subtype is also located in BASAL GANGLIA and CEREBRAL CORTEX of the BRAIN where it mediates the effects of HALLUCINOGENS such as LSD.

Registry Number: 0

Descriptor UI: D044402

Alternative terms: Receptor, Serotonin, 5-HT2A; 5-HT2A Receptor; 5 HT2A Receptor; Receptor, 5-HT2A; Serotonin 2A Receptors; 2A Receptors, Serotonin; Receptors, Serotonin 2A; Serotonin 2A Receptor; 5-HT(2A) Receptor; Receptor, Serotonin 2A; 2A Receptor, Serotonin;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.070.800.200.100; D12.776.543.750.100.800.200.100; D12.776.543.750.720.300.800.200.100;

History Note: 2004; use RECEPTOR, SEROTONIN, 5-HT2A (NM) 1994-2003