Receptor, Serotonin, 5-HT2C
Research News and Information

Sunday, November 22, 2009

In vivo evidence that constitutive activity of serotonin2C receptors in the medial prefrontal cortex participates in the control of dopamine release in the rat nucleus accumbens: differential effects of inverse agonist versus antagonist.

20 Aug 2009 Control of the mesoaccumbens dopamine (DA) pathway by central serotonin(2C) receptors (5-HT(2C)Rs) involves different 5-HT(2C)R populations located within multiple brain areas. Here, using in vivo microdialysis in halothane-anesthetized rats, we ... Read more...

Agomelatine prevents relapse in patients with major depressive disorder without evidence of a discontinuation syndrome: a 24-week randomized, double-blind, placebo-controlled trial.

9 Aug 2009 OBJECTIVE: This study evaluates the efficacy of agomelatine, the first antidepressant that is an agonist at MT(1)/MT(2) receptors and an antagonist at 5-HT(2C) receptor, in the prevention of relapse of depression following successful response. ... Read more...

Implication of the 5-HT2A and 5-HT2C (but not 5HT1A) receptors located within the periaqueductal gray in the elevated plus-maze test-retest paradigm in mice.

17 Jul 2009 A single exposure to the elevated plus-maze test (EPM) increases open arms avoidance and reduces or abolishes the anxiolytic-like effect of benzodiazepines assessed during a second trial, a phenomenon defined as "one-trial tolerance" (OTT). It has ... Read more...

Latest indexed articles for 'Receptor, Serotonin, 5-HT2C'

These are the very latest articles for this heading:

• In vivo evidence that constitutive activity of serotonin2C receptors in the medial prefrontal cortex participates in the control of dopamine release in the rat nucleus accumbens: differential effects of inverse agonist versus antagonist. 20 Aug 2009
• Agomelatine prevents relapse in patients with major depressive disorder without evidence of a discontinuation syndrome: a 24-week randomized, double-blind, placebo-controlled trial. 9 Aug 2009
• Selective serotonin reuptake inhibitor-induced spermatorrhea in 2 patients. 30 Jul 2009
• Implication of the 5-HT2A and 5-HT2C (but not 5HT1A) receptors located within the periaqueductal gray in the elevated plus-maze test-retest paradigm in mice. 17 Jul 2009
• Serotonin receptor 2C and mental disorders: genetic, expression and RNA editing studies. 8 Jul 2009
• Focus on HTR2C: A possible suggestion for genetic studies of complex disorders. 3 Jul 2009
• Antidepressive-drug-induced bodyweight gain is associated with polymorphisms in genes coding for COMT and TPH1. 29 Jun 2009
• Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism. 24 Jun 2009
• Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function. 22 Jun 2009
• Serotonin 5-HT2C receptor-independent expression of hypothalamic NOR1, a novel modulator of food intake and energy balance, in mice. 8 Jun 2009
• Editing of serotonin 2C receptor mRNA in the prefrontal cortex characterizes high-novelty locomotor response behavioral trait. Jun 2009
• PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors. Jun 2009
• 5-HT2C-like receptors in the brain of Xenopus laevis initiate sex-typical fictive vocalizations. 25 May 2009
• Gene expression and mRNA editing of serotonin receptor 2C in brains of HPRT gene knock-out mice, an animal model of Lesch-Nyhan disease. 24 May 2009
• Genes within the serotonergic system are differentially expressed in human brain. 13 May 2009
• Olanzapine-induced weight gain is associated with the -759C/T and -697G/C polymorphisms of the HTR2C gene. 10 May 2009
• Serotonergic modulation of odor input to the mammalian olfactory bulb. 8 May 2009
• Promoter and functional polymorphisms of HTR2C and suicide victims. 6 May 2009
• Identification of novel serotonin 2C receptor ligands by sequential virtual screening. 6 May 2009
• Large-scale mRNA sequencing determines global regulation of RNA editing during brain development. 4 May 2009

See a longer list of these articles.

Technical information about 'Receptor, Serotonin, 5-HT2C'

Definition: A serotonin receptor subtype found primarily in the CENTRAL NERVOUS SYSTEM and the CHOROID PLEXUS. This receptor subtype is believed to mediate the anorectic action of SEROTONIN, while selective antagonists of the 5-HT2C receptor appear to induce ANXIETY. Several isoforms of this receptor subtype exist, due to adenine deaminase editing of the receptor mRNA.

Registry Number: 0

Descriptor UI: D044405

Alternative terms: Receptor, Serotonin, 5-HT2C; 5-HT2C Receptor; 5 HT2C Receptor; Receptor, 5-HT2C; 5-Hydroxytryptamine Type 2C Receptor; 5 Hydroxytryptamine Type 2C Receptor; Serotonin 2C Receptor; 2C Receptor, Serotonin; Receptor, Serotonin 2C; 5-Hydroxytryptamine Type 2C Receptors; 5 Hydroxytryptamine Type 2C Receptors; Receptor, 5-Hydroxytryptamine Type 2C; Receptor, 5 Hydroxytryptamine Type 2C; 5-HT(2C) Receptor;

Allowable Qualifiers: administration & dosage; analysis; antagonists & inhibitors; biosynthesis; blood; classification; deficiency; drug effects; genetics; history; immunology; isolation & purification; metabolism; physiology; radiation effects; therapeutic use; ultrastructure; chemistry; agonists;

Tree Number: D12.776.543.750.070.800.200.575; D12.776.543.750.100.800.200.200; D12.776.543.750.720.300.800.200.200;

History Note: 2004; use RECEPTOR, SEROTONIN, 5-HT2C (NM) 1994-2003